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. 1984 Mar;140(3):398–402.

Bronchodilatory Effect of Warm Air Inhalation During Quiet Breathing

Jerome E Carbone, John J Marini
PMCID: PMC1021697  PMID: 6710981

Abstract

To evaluate the effects of air warming and humidification, we examined the spirometric responses before and after exposure to a conditioned airsteam. Seven healthy subjects, seven clinically stable patients with chronic bronchitis and seven clinically stable asthmatic patients were studied during quiet breathing. All were exposed to the following air conditions for ten minutes: −20°C, dry; 37°C, dry; 37°C, fully saturated; 50°C, dry, and 50°C, fully saturated. As heat increased, airflow progressively improved in asthmatic persons as a group. In contrast, patients with chronic bronchitis, who had more severe underlying airflow obstruction, had most improved airflow with warm dry air inhalation and showed less improvement as humidity was added isothermally. We conclude that active warming of air before inhalation can improve airflow significantly in some patients with reactive obstructed airways, and that high degrees of humidity may exert an independent adverse effect in persons with chronic bronchitis or in those with serious airflow obstruction.

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Selected References

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  1. Breslin F. J., McFadden E. R., Jr, Ingram R. H., Jr, Deal E. C., Jr Effects of atropine on respiratory heat loss in asthma. J Appl Physiol Respir Environ Exerc Physiol. 1980 Apr;48(4):619–623. doi: 10.1152/jappl.1980.48.4.619. [DOI] [PubMed] [Google Scholar]
  2. Chen W. Y., Horton D. J. Heat and water loss from the airways and exercise-induced asthma. Respiration. 1977;34(6):305–313. doi: 10.1159/000193842. [DOI] [PubMed] [Google Scholar]
  3. Cheney F. W., Jr, Butler J. The effects of ultrasonically-produced aerosols on airway resistance in man. Anesthesiology. 1968 Nov-Dec;29(6):1099–1106. doi: 10.1097/00000542-196811000-00004. [DOI] [PubMed] [Google Scholar]
  4. Deal E. C., Jr, McFadden E. R., Jr, Ingram R. H., Jr, Jaeger J. J. Effects of atropine on potentiation of exercise-induced bronchospasm by cold air. J Appl Physiol Respir Environ Exerc Physiol. 1978 Aug;45(2):238–243. doi: 10.1152/jappl.1978.45.2.238. [DOI] [PubMed] [Google Scholar]
  5. Deal E. C., Jr, McFadden E. R., Jr, Ingram R. H., Jr, Jaeger J. J. Hyperpnea and heat flux: initial reaction sequence in exercise-induced asthma. J Appl Physiol Respir Environ Exerc Physiol. 1979 Mar;46(3):476–483. doi: 10.1152/jappl.1979.46.3.476. [DOI] [PubMed] [Google Scholar]
  6. Deal E. C., Jr, McFadden E. R., Jr, Ingram R. H., Jr, Strauss R. H., Jaeger J. J. Role of respiratory heat exchange in production of exercise-induced asthma. J Appl Physiol Respir Environ Exerc Physiol. 1979 Mar;46(3):467–475. doi: 10.1152/jappl.1979.46.3.467. [DOI] [PubMed] [Google Scholar]
  7. Deal E. C., Jr, Wasserman S. I., Soter N. A., Ingram R. H., Jr, McFadden E. R., Jr Evaluation of role played by mediators of immediate hypersensitivity in exercise-induced asthma. J Clin Invest. 1980 Mar;65(3):659–665. doi: 10.1172/JCI109711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hay R. J., Williams C. D., Macy M. L., Lavappa K. S. Cultured cell lines for research on pulmonary physiology available through the American type culture collection. Am Rev Respir Dis. 1982 Feb;125(2):222–232. doi: 10.1164/arrd.1982.125.2.222. [DOI] [PubMed] [Google Scholar]
  9. Hay R. J., Williams C. D., Macy M. L., Lavappa K. S. Cultured cell lines for research on pulmonary physiology available through the American type culture collection. Am Rev Respir Dis. 1982 Feb;125(2):222–232. doi: 10.1164/arrd.1982.125.2.222. [DOI] [PubMed] [Google Scholar]
  10. Josenhans W. T., Melville G. N., Ulmer W. T. Effects of humidity in inspired air on airway resistance and functional residual capacity in patients with respiratory diseases. Respiration. 1969;26(6):435–442. doi: 10.1159/000192624. [DOI] [PubMed] [Google Scholar]
  11. Kwock L., Douglas W. H., Lin P. S., Baur W. E., Fanburg B. L. Endothelial cell damage after gamma-irradiation in vitro: impaired uptake of alpha-aminoisobutyric acid. Am Rev Respir Dis. 1982 Jan;125(1):95–99. doi: 10.1164/arrd.1982.125.1.95. [DOI] [PubMed] [Google Scholar]
  12. McCUTCHAN J. W., TAYLOR C. L. Respiratory heart exchange with varying temperature and humidity of inspired air. J Appl Physiol. 1951 Aug;4(2):121–135. doi: 10.1152/jappl.1951.4.2.121. [DOI] [PubMed] [Google Scholar]
  13. McFadden E. R., Jr, Ingram R. H., Jr Exercise-induced asthma: Observations on the initiating stimulus. N Engl J Med. 1979 Oct 4;301(14):763–769. doi: 10.1056/NEJM197910043011406. [DOI] [PubMed] [Google Scholar]
  14. McFadden E. R., Jr, Stearns D. R., Ingram R. H., Jr, Leith D. E. Relative contributions of hypocarbia and hyperpnea as mechanisms in postexercise asthma. J Appl Physiol Respir Environ Exerc Physiol. 1977 Jan;42(1):22–27. doi: 10.1152/jappl.1977.42.1.22. [DOI] [PubMed] [Google Scholar]
  15. Melville G. N., Josenhans W. T., Ulmer W. T. Changes in specific airway resistance during prolonged breathing of moist air. Can J Physiol Pharmacol. 1970 Sep;48(9):592–597. doi: 10.1139/y70-090. [DOI] [PubMed] [Google Scholar]
  16. Ramsey J. M. Time course of bronchoconstrictive response in asthmatic subjects to reduced temperature. Thorax. 1977 Feb;32(1):26–28. doi: 10.1136/thx.32.1.26. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Sheppard D., Epstein J., Holtzman M. J., Nadel J. A., Boushey H. A. Dose-dependent inhibition of cold air-induced bronchoconstriction by atropine. J Appl Physiol Respir Environ Exerc Physiol. 1982 Jul;53(1):169–174. doi: 10.1152/jappl.1982.53.1.169. [DOI] [PubMed] [Google Scholar]
  18. Simonsson B. G., Jacobs F. M., Nadel J. A. Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airway disease. J Clin Invest. 1967 Nov;46(11):1812–1818. doi: 10.1172/JCI105671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Strauss R. H., McFadden E. R., Jr, Ingram R. H., Jr, Deal E. C., Jr, Jaeger J. J. Influence of heat and humidity on the airway obstruction induced by exercise in asthma. J Clin Invest. 1978 Feb;61(2):433–440. doi: 10.1172/JCI108954. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Strauss R. H., McFadden E. R., Jr, Ingram R. H., Jr, Jaeger J. J. Enhancement of exercise-induced asthma by cold air. N Engl J Med. 1977 Oct 6;297(14):743–747. doi: 10.1056/NEJM197710062971402. [DOI] [PubMed] [Google Scholar]
  21. WALKER J. E., WELLS R. E., Jr, MERRILL E. W. Heat and water exchange in the respiratory tract. Am J Med. 1961 Feb;30:259–267. doi: 10.1016/0002-9343(61)90097-3. [DOI] [PubMed] [Google Scholar]
  22. Watanabe S., Renzetti A. D., Jr, Begin R., Bigler A. H. Airway responsiveness to a bronchodilator aerosol. I. Normal human subjects. Am Rev Respir Dis. 1974 May;109(5):530–537. doi: 10.1164/arrd.1974.109.5.530. [DOI] [PubMed] [Google Scholar]

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