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. 2023 Apr 21;39(5):btad276. doi: 10.1093/bioinformatics/btad276

Figure 5.

Figure 5.

Understanding increments and reductions in spongEffects scores. Increments in spongEffects scores can result from Scenario 1: an increase in the expression of a module’s central ceRNA while miRNA expression levels remain constant, leading them to upregulation of the module’s target ceRNAs, and/or Scenario 2: a decrease in the expression of a module’s miRNAs that results in higher expression of the module ceRNAs. Negative spongEffects scores can result from Scenario 3: a decrease of expression in the module’s central ceRNA while miRNA expression levels remain constant, leading to the downregulation of the module’s target ceRNAs, and/or Scenario 4: an increase of expression in a module’s miRNAs that results in lower expression of the module’s target ceRNAs.