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. 1993 May;158(5):480–483.

Human T-lymphotropic virus type I seroprevalence among Japanese Americans.

E L Murphy 1, K F Varney 1, N T Miyasaki 1, R J Moore 1, J I Umekubo 1, A N Watanabe 1, H Khayam-Bashi 1
PMCID: PMC1022128  PMID: 8342263

Abstract

The epidemiology of human T-lymphotropic virus type I (HTLV-I) infection is not well defined in Japanese Americans. This impairs using approaches that could reduce viral transmission and monitor carriers for the disease. Using enzyme-linked immunosorbent assay and p21e recombinant Western blot testing, HTLV-I antibody was measured in unlinked samples from Japanese-American patients at 4 physicians' offices in San Francisco, California. Of 442 patients, 4 (0.9%; 95% confidence interval 0.25%, 2.3%) were confirmed seropositive, all with an HTLV-I rather than an HTLV-II pattern on Western blot. Seroprevalence was highest among the issei or immigrant generation (3/230 or 1.3%) compared with the second-generation nisei (1/191 or 0.5%) or third-generation sansei (0 of 17). Prevalence did not differ by age or sex, although the number of positive subjects in each subgroup was small. Of 88 patients with familial origins in endemic areas of southern Japan, none were seropositive. In this sample of Japanese Americans, HTLV-I seroprevalence was lower than in residents of endemic southern Japan but higher than among American blood donors. The prevalence was most similar to that in nonendemic areas of Japan. The public health implications of HTLV-I infection among Japanese Americans are discussed.

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Selected References

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  1. Blattner W. A., Nomura A., Clark J. W., Ho G. Y., Nakao Y., Gallo R., Robert-Guroff M. Modes of transmission and evidence for viral latency from studies of human T-cell lymphotrophic virus type I in Japanese migrant populations in Hawaii. Proc Natl Acad Sci U S A. 1986 Jul;83(13):4895–4898. doi: 10.1073/pnas.83.13.4895. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Clark J. W., Gurgo C., Franchini G., Gibbs W. N., Lofters W., Neuland C., Mann D., Saxinger C., Gallo R. C., Blattner W. A. Molecular epidemiology of HTLV-I-associated non-Hodgkin's lymphomas in Jamaica. Cancer. 1988 Apr 1;61(7):1477–1482. doi: 10.1002/1097-0142(19880401)61:7<1477::aid-cncr2820610735>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  3. Cruickshank J. K., Richardson J. H., Morgan O. S., Porter J., Klenerman P., Knight J., Newell A. L., Rudge P., Dalgleish A. G. Screening for prolonged incubation of HTLV-I infection in British and Jamaican relatives of British patients with tropical spastic paraparesis. BMJ. 1990 Feb 3;300(6720):300–304. doi: 10.1136/bmj.300.6720.300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gessain A., Barin F., Vernant J. C., Gout O., Maurs L., Calender A., de Thé G. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet. 1985 Aug 24;2(8452):407–410. doi: 10.1016/s0140-6736(85)92734-5. [DOI] [PubMed] [Google Scholar]
  5. Hino S., Sugiyama H., Doi H., Ishimaru T., Yamabe T., Tsuji Y., Miyamoto T. Breaking the cycle of HTLV-I transmission via carrier mothers' milk. Lancet. 1987 Jul 18;2(8551):158–159. doi: 10.1016/s0140-6736(87)92358-0. [DOI] [PubMed] [Google Scholar]
  6. Hino S., Yamaguchi K., Katamine S., Sugiyama H., Amagasaki T., Kinoshita K., Yoshida Y., Doi H., Tsuji Y., Miyamoto T. Mother-to-child transmission of human T-cell leukemia virus type-I. Jpn J Cancer Res. 1985 Jun;76(6):474–480. [PubMed] [Google Scholar]
  7. Hinuma Y., Komoda H., Chosa T., Kondo T., Kohakura M., Takenaka T., Kikuchi M., Ichimaru M., Yunoki K., Sato I. Antibodies to adult T-cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: a nation-wide sero-epidemiologic study. Int J Cancer. 1982 Jun 15;29(6):631–635. doi: 10.1002/ijc.2910290606. [DOI] [PubMed] [Google Scholar]
  8. Ho G. Y., Nomura A. M., Nelson K., Lee H., Polk B. F., Blattner W. A. Declining seroprevalence and transmission of HTLV-I in Japanese families who immigrated to Hawaii. Am J Epidemiol. 1991 Nov 1;134(9):981–987. doi: 10.1093/oxfordjournals.aje.a116183. [DOI] [PubMed] [Google Scholar]
  9. Kline R. L., Brothers T., Halsey N., Boulos R., Lairmore M. D., Quinn T. C. Evaluation of enzyme immunoassays for antibody to human T-lymphotropic viruses type I/II. Lancet. 1991 Jan 5;337(8732):30–33. doi: 10.1016/0140-6736(91)93343-8. [DOI] [PubMed] [Google Scholar]
  10. Maeda Y., Furukawa M., Takehara Y., Yoshimura K., Miyamoto K., Matsuura T., Morishima Y., Tajima K., Okochi K., Hinuma Y. Prevalence of possible adult T-cell leukemia virus-carriers among volunteer blood donors in Japan: a nation-wide study. Int J Cancer. 1984 Jun 15;33(6):717–720. doi: 10.1002/ijc.2910330602. [DOI] [PubMed] [Google Scholar]
  11. Manns A., Wilks R. J., Murphy E. L., Haynes G., Figueroa J. P., Barnett M., Hanchard B., Blattner W. A. A prospective study of transmission by transfusion of HTLV-I and risk factors associated with seroconversion. Int J Cancer. 1992 Jul 30;51(6):886–891. doi: 10.1002/ijc.2910510609. [DOI] [PubMed] [Google Scholar]
  12. Murphy E. L., Blattner W. A. HTLV-I-associated leukemia: a model for chronic retroviral diseases. Ann Neurol. 1988;23 (Suppl):S174–S180. doi: 10.1002/ana.410230739. [DOI] [PubMed] [Google Scholar]
  13. Murphy E. L., Figueroa J. P., Gibbs W. N., Brathwaite A., Holding-Cobham M., Waters D., Cranston B., Hanchard B., Blattner W. A. Sexual transmission of human T-lymphotropic virus type I (HTLV-I). Ann Intern Med. 1989 Oct 1;111(7):555–560. doi: 10.7326/0003-4819-111-7-555. [DOI] [PubMed] [Google Scholar]
  14. Murphy E. L., Figueroa J. P., Gibbs W. N., Holding-Cobham M., Cranston B., Malley K., Bodner A. J., Alexander S. S., Blattner W. A. Human T-lymphotropic virus type I (HTLV-I) seroprevalence in Jamaica. I. Demographic determinants. Am J Epidemiol. 1991 Jun 1;133(11):1114–1124. doi: 10.1093/oxfordjournals.aje.a115824. [DOI] [PubMed] [Google Scholar]
  15. Okochi K., Sato H., Hinuma Y. A retrospective study on transmission of adult T cell leukemia virus by blood transfusion: seroconversion in recipients. Vox Sang. 1984;46(5):245–253. doi: 10.1111/j.1423-0410.1984.tb00083.x. [DOI] [PubMed] [Google Scholar]
  16. Poiesz B. J., Ruscetti F. W., Gazdar A. F., Bunn P. A., Minna J. D., Gallo R. C. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7415–7419. doi: 10.1073/pnas.77.12.7415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Rodgers-Johnson P., Gajdusek D. C., Morgan O. S., Zaninovic V., Sarin P. S., Graham D. S. HTLV-I and HTLV-III antibodies and tropical spastic paraparesis. Lancet. 1985 Nov 30;2(8466):1247–1248. doi: 10.1016/s0140-6736(85)90778-0. [DOI] [PubMed] [Google Scholar]
  18. Tajima K., Tominaga S., Suchi T., Fukui H., Komoda H., Hinuma Y. HTLV-I carriers among migrants from an ATL-endemic area to ATL non-endemic metropolitan areas in Japan. Int J Cancer. 1986 Mar 15;37(3):383–387. doi: 10.1002/ijc.2910370309. [DOI] [PubMed] [Google Scholar]
  19. Tsugane S., Watanabe S., Sugimura H., Otsu T., Tobinai K., Shimoyama M., Nanri S., Ishii H. Infectious states of human T lymphotropic virus type I and hepatitis B virus among Japanese immigrants in the Republic of Bolivia. Am J Epidemiol. 1988 Nov;128(5):1153–1161. doi: 10.1093/oxfordjournals.aje.a115058. [DOI] [PubMed] [Google Scholar]
  20. Ueda K., Kusuhara K., Tokugawa K., Miyazaki C., Yoshida C., Tokumura K., Sonoda S., Takahashi K. Cohort effect on HTLV-I seroprevalence in southern Japan. Lancet. 1989 Oct 21;2(8669):979–979. doi: 10.1016/s0140-6736(89)90986-0. [DOI] [PubMed] [Google Scholar]
  21. Wiktor S. Z., Alexander S. S., Shaw G. M., Weiss S. H., Murphy E. L., Wilks R. J., Shortly V. J., Hanchard B., Blattner W. A. Distinguishing between HTLV-I and HTLV-II by western blot. Lancet. 1990 Jun 23;335(8704):1533–1533. doi: 10.1016/0140-6736(90)93078-4. [DOI] [PubMed] [Google Scholar]
  22. Williams A. E., Fang C. T., Slamon D. J., Poiesz B. J., Sandler S. G., Darr W. F., 2nd, Shulman G., McGowan E. I., Douglas D. K., Bowman R. J. Seroprevalence and epidemiological correlates of HTLV-I infection in U.S. blood donors. Science. 1988 Apr 29;240(4852):643–646. doi: 10.1126/science.2896386. [DOI] [PubMed] [Google Scholar]

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