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. 2023 May 27;20:9. doi: 10.1186/s12977-023-00624-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Neutralization efficacy of BG505 and B41 pseudovirus. The extent of neutralization (%) of PV in a TZM-bl assay is plotted as a function of NAb concentration (μg/ml); means ± s.e.m. of 2–4 replicate titrations are shown. Neutralization by the three bNAbs 2G12 (N332 glycan), PGT145 (V2-apex), and PGT151 (gp41-gp120 interface) of BG505 PV (A) and B41 (B) gave different potencies and efficacies. C The log₁₀ of the relative remaining infectivity after neutralization by bNAb at a fixed concentration (50 μg/ml) is plotted as a function of the log₁₀ of varied viral inoculum dilution. D The schematic shows the procedure for partial depletion of a PV preparation by the absorption of virions binding most avidly to bNAbs on beads