Table 2.

Maximum changes in log CFU/mL compared to the starting inoculum in time–kill studies at different anidulafungin (mg/L), and anidulafungin (mg/L) plus 8 mg/L nikkomycin Z concentrations (mg/L) for the four Candida auris clades. Data in bold and underlined indicate a synergistic (more than 2 log CFU decreases in CFU) and fungicidal effect (at least 3 log decreases in CFU), respectively.

Clade	Isolate Number	Maximum Log Decreases/Increases in CFU in Time–Killing Experiments at the Indicated Anidulafungin and Anidulafungin + Nikkomycin Z Concentrations
		Anidulafungin (mg/L)					Anidulafungin (mg/L) + Nikkomycin Z (mg/L)
		0.25	1	8	16	32	0.25 + 8	1 + 8	8 + 8	16 + 8	32 + 8
South Asian	20	−0.27 *	−0.22 *	−0.29 *	−0.88	−0.74	−0.69	−1.0	−1.57	−1.48	−1.57
	27	−0.61	−1.04	−1.4	−1.32	−1.4	−2.3	−2.78	−3.16	−3.22	−3.05
	28	+2.39	−0.22 *	−0.19 *	+0.88	+0.54	+1.42	−0.05 *	−0.10 *	−0.10 *	−0.08 *
	196	−0.39	−0.57	−0.42	−0.62	−0.96	−2.54	−3.02	−3.02	−3.02	−3.02
	208	−0.08 *	+1.24	+1.22	+0.82	+0.52	+1.40	+1.10	−0.15 *	−0.10 *	−0.43
East Asian	Type strain	−1.15 *	−1.54 *	−1.98	−1.98	−3.0	−1.0	−1.13	−2.13	−3.9	−3.9
	12372	−0.58 *	−0.54 *	−1.42 *	−1.18 *	−1.23 *	−0.87 *	−1.92	−3.85	−3.85	−3.85
	12373	−0.52 *	−0.62 *	−0.62 *	−0.70 *	−0.80 *	−1.0	−2.22	−4.0	−4.0	−4.0
South African	2	+0.45	+0.24	+0.26	+0.32	+0.26	−1.28	−1.30	−1.41	−1.48	−1.60
	204	−0.35 *	−0.03 *	−0.19 *	+0.33	−0.15 *	−0.83	−0.95	−1.20	−1.32	−1.82
	206	+0.48	+0.51	+0.54	−0.19 *	−0.92 *	−0.34 *	−0.21 *	−0.22 *	−0.29 *	−0.44 *
South American (from Israel)	I-24	−0.33 *	−0.27 *	−0.22 *	−0.19 *	−0.11 *	−0.57	−0.69	−0.77	−0.82	−1.32
	I-156	−0.35 *	−0.18 *	−0–14 *	−0.22 *	−0–15 *	−0.85	−1.22	−1.41	−1.71	−2.26
South American (from Colombia)	13108	−0.96	−0.77	−0.78	−0.78	−0.48	−4.08	−4.08	−4.08	−4.08	−4.08
	16565	−2.3	−1.7	−1.09	−0.79	−0.99	−4.15	−4.15	−4.15	−4.15	−4.15

* Regrowth.