Nanoparticles zinc paste bandages for the treatment of Syrian woman diabetic patient with ulcers in the foot: Case images

Key Clinical Message

Treatments of secondary diseases such as the ulcer in the skin and thromboembolic diseases in the venous are significant procedures for lots of patients of main diseases which cause them. Herein, effective nano‐particles are used for the treatment.

1. INTRODUCTION

Zinc paste bandage is an important type of the bandages used for the treatments of some types of the venous diseases such as thromboembolic diseases in the venous, and chronic diseases in the venous. Some of these diseases can resulted from lots of other internal diseases such as diabetes. These types of diseases can be treated by the using of the traditional types of pastes or by using of new types of pastes such as the pastes with nanoparticles fillers. There is more than one type of the zinc paste bandages which are used for the previous treatment. One of the important types of the zinc paste bandages is the type which includes zinc nanoparticles. The using of the zinc nanoparticles in the medical field has increased in the recent years. ¹ , ² The zinc nanoparticles have multiple significant biomedical applications such as using for the care of skin and for the leg ulcers treatments. The using of the zinc nanoparticles for the treatment of ulcers has multiple effective results such as the speed of treatment. The use of zinc nanoparticles accelerates the healing of ulcers in the diabetic foot. In this report, we present the use of zinc nanoparticle bandages for a 60‐year‐old Syrian woman and the effectiveness of these nanoparticles.

2. CASE REPRESENTATION

In this case report, we reported Syrian woman, 60 years old, she is a patient with diabetes. The history of the patient is as follows: when the woman was 55 years old, she developed diabetes. At the age of 59, she suffered severe ulcers on her finger and foot, which led to the amputation of her finger. At that time, she began to be treated with Roseflix injections‐Ceftriaxone 2.5 g in addition to Flagyl injections. The patient was taking the dose weekly. The patient started to treat with the zinc paste bandages as the images in the Figure 1, Unna boots. During the period when the patient was being treated with zinc nanoparticles, she stopped treatment with Rosflex and Flagyl injections. In addition, the patient was instructed to take care of the foot hygiene continuously and not to walk barefoot during the entire treatment period using zinc nanoparticles. The effectiveness zinc nanoparticle ratio was 70%. She had amputation of a finger of her foot, and an ulcer in the skin of her foot. Previously, the patient had used the honey bandages for the treatment and no actual responses for her case had been recorded. Although, when we started to apply the zinc paste bandages with nanoparticles 70%, the skin of her foot started to recover in clear way. As it can be seen from the images of the foot of patient, the ulcers of the foot before applying the nanoparticles zinc paste were covered about a half of her foot. After the treatment by the using of the nanoparticles zinc paste bandages for 5 weeks, the ulcers were reduced to very small area on her foot. The upper‐right corner side of the image represents the ulcers on her foot (Number‐1) before applying the nanoparticles zinc paste bandages. The upper‐lift corner of the image represents the ulcers of the foot after applying the nanoparticles zinc paste bandages for the first week of the treatment (Number‐2), while the lower‐right corner of the image represents the ulcers of the foot after applying the nanoparticles for 4 weeks (Number‐3). In the lower‐left corner of the image (Number‐4), we included the ulcers after the finishing of the treatment. The main conclusion remarks of this treatment case report are return to the effective results of applying the nanoparticles zinc paste. Although, the using of the nanoparticles zinc paste is an effective way in the biomedical applications, recent study ³ found that there were some toxic effects of using of those particles in unclear ways. The toxicity of the zinc nanoparticles was raised from their effects on the broken skin or on the damaged skin. The main reasons of the toxicity of the zinc nanoparticles returns to the solubility of the particles, which increases when the concentration of the zinc nanoparticles increases. the these effects return to the penetrating of the nanoparticles into the cells of skin, and these particles can interact with those cells based on the concentration of the particles.

FIGURE 1.

The case treated with zinc paste bandages.

AUTHOR CONTRIBUTIONS

Reham Alwis: Conceptualization; formal analysis; investigation; methodology; resources; validation; visualization; writing – original draft; writing – review and editing. Razan Alwis: Conceptualization; data curation; formal analysis; investigation; methodology; project administration; resources; writing – original draft; writing – review and editing. Marwan Al‐Raeei: Conceptualization; data curation; formal analysis; investigation; methodology; project administration; resources; software; supervision; visualization; writing – original draft; writing – review and editing.

FUNDING INFORMATION

None.

CONFLICT OF INTEREST STATEMENT

No conflict of interests.

ETHICAL APPROVAL

The authors have followed all of the ethics publishing terms.

CONSENT

Written informed consent was obtained from the patient to publish this report in accordance with the journal's patient consent policy.

CLINICAL TRIAL REGISTRATION

The authors have the clinical trial registration in the RW clinic.

Alwis R, Alwis R, Al‐Raeei M. Nanoparticles zinc paste bandages for the treatment of Syrian woman diabetic patient with ulcers in the foot: Case images. Clin Case Rep. 2023;11:e7445. doi: 10.1002/ccr3.7445

DATA AVAILABILITY STATEMENT

All data are included in the manuscript.