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. 2023 May 31;29(3):306–309. [Article in German] doi: 10.1007/s12268-023-1942-7

Meilensteine in der Algenbiotechnologie

Carola Griehl 1, Andreas Schmid 2, Christian Wilhelm 3,✉
PMCID: PMC10230451  PMID: 37275943

Abstract

Recent progress in algal biotechnology has identified new products based on their broad evolutionary origin. Novel metabolites were found for pharmacy, food industry, medicine e.g. tumor suppression and antibiotics. However, sustainable and economical algal production for crude oil replacement is limited by extremely low space time yields in photobioreactors. The consequences are a high energy burden for mass flow dependent processes and the need of space being in conflict with sustainable landscape management. New concepts using algae not as biomass producers but as living catalysts may open new options.

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Funding note

Open Access funding enabled and organized by Projekt DEAL.

Literatur

  • [1].Araújo R, Vázquez Calderón F, Sánchez López J, et al. Current status of the algae production industry in Europe: an emerging sector of the blue bioeconomy. Front Marine Sci. 2021;7:626389. doi: 10.3389/fmars.2020.626389. [DOI] [Google Scholar]
  • [2].Hielscher-Michael S, Griehl C, Buchholz M, et al. Natural products from microalgae with potential against Alzheimer’s disease: Sulfolipids are potent glutaminyl cyclase inhibitors. Marine Drugs. 2016;14:203. doi: 10.3390/md14110203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [3].Flynn K (2017) Algal biofuel production is neither environmentally nor commercially sustainable. https://www-2018.swansea.ac.uk/press-office/news-archive/2017/algalbiofuelproductionisneitherenvironmentallynorcommercially-sustainable.php; Letzter Zugriff: 22.04.2023
  • [4].Franz A, Lehr F, Posten C, Schaub G. Modeling microalgae cultivation productivities in different geographic locations–estimation method for idealized photobioreactors. Biotechnol J. 2012;7:546–557. doi: 10.1002/biot.201000379. [DOI] [PubMed] [Google Scholar]
  • [5].Kachrimanidou V, Vlysidis A, Kopsahelis N, Kookos IK. Increasing the volumetric productivity of fermentative ethanol production using a fed-batch vacuferm process. Biomass Conversion Biorefinery. 2021;11:673–680. doi: 10.1007/s13399-020-00673-6. [DOI] [Google Scholar]
  • [6].Andrews F, Faulkner M, Toogood HS, Scrutton NS. Combinatorial use of environmental stresses and genetic engineering to increase ethanol titres in cyanobacteria. Biotechnol Biofuels. 2021;14:240. doi: 10.1186/s13068-021-02091-w. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [7].Posten C. Design principles of photo -bioreactors for cultivation of microalgae. Eng Life Sci. 2009;9:165–177. doi: 10.1002/elsc.200900003. [DOI] [Google Scholar]
  • [8].Brandenburg F, Klähn S, Schmid A, Krömer JO. Produktion von Aminosäurederivaten in Cyanobakterien. BIOspektrum. 2022;28:341–343. doi: 10.1007/s12268-022-1756-z. [DOI] [Google Scholar]
  • [9].Brandenburg F, Theodosiou E, Bertelmann C, et al. Trans-4-hydroxy-L-proline production by the cyanobacterium Synechocystis sp. PCC 6803. Metabol Eng Commun. 2021;12:e00155. doi: 10.1016/j.mec.2020.e00155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [10].Matthes S, Matschke M, Cotta F, et al. Reliable production of microalgae biomass using a novel microalgae platform. J Appl Phycol. 2015;27:1755–1762. doi: 10.1007/s10811-014-0502-4. [DOI] [Google Scholar]
  • [11].Nwoba EG, Parlevliet DA, Laird DW, et al. Pilot-scale self-cooling microalgal closed photobioreactor for biomass production and electricity generation. Algal Res. 2020;45:101731. doi: 10.1016/j.algal.2019.101731. [DOI] [Google Scholar]
  • [12].Daneshvar E, Wicker RJ, Show PL, Bhatnagar A. Biologically-mediated carbon capture and utilization by microalgae towards sustainable CO2 biofixation and biomass valorization–A review. Chem Eng J. 2022;427:130884. doi: 10.1016/j.cej.2021.130884. [DOI] [Google Scholar]
  • [13].Hoschek A (2019) Whole-cell redox biocatalysis driven by photosynthesis: an integrated bioprocess design for phototrophic biocatalysts. Chemical Biotechnology 31. Shaker, Aachen.
  • [14].Griehl C, Kleinert C, Griehl C, Bieler S. Design of a continuous milking bioreactor for non-destructive hydrocarbon extraction from Botryococcus braunii. J Appl Phycol. 2015;27:1833–1843. doi: 10.1007/s10811-014-0472-6. [DOI] [Google Scholar]
  • [15].Kleinert C, Griehl C. In situ extraction (milking) of the two promising Botryococcus braunii strains Showa and Bot22 under optimized extraction time. J Appl Phycol. 2022;34:269–283. doi: 10.1007/s10811-021-02633-7. [DOI] [Google Scholar]
  • [16].Günther A, Jakob T, Goss R, et al. Methane production from glycolate excreting algae as a new concept in the production of biofuels. Bioresour Technol. 2012;121:454–457. doi: 10.1016/j.biortech.2012.06.120. [DOI] [PubMed] [Google Scholar]
  • [17].Taubert A, Jakob T, Wilhelm C. Glycolate from microalgae: an efficient carbon source for biotechnological applications. Plant Biotechnol J. 2019;17:1538–1546. doi: 10.1111/pbi.13078. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [18].Toepel J, Karande R, Bühler B, et al. Photosynthesis driven continuous hydrogen production by diazotrophic cyanobacteria in high cell density capillary photobiofilm reactors. Bioresour Technol. 2023;373:128703. doi: 10.1016/j.biortech.2023.128703. [DOI] [PubMed] [Google Scholar]
  • [19].Hoschek A, Heuschkel I, Schmid A, et al. Mixed-species biofilms for high-cell-density application of Synechocystis sp. PCC 6803 in capillary reactors for continuous cyclohexane oxidation to cyclohexanol. Bioresour Technol. 2019;282:171–178. doi: 10.1016/j.biortech.2019.02.093. [DOI] [PubMed] [Google Scholar]
  • [20].Karan H, Roles J, Ross IL, et al. Solar biorefinery concept for sustainable co-production of microalgae-based protein and renewable fuel. J Cleaner Prod. 2022;368:132981. doi: 10.1016/j.jclepro.2022.132981. [DOI] [Google Scholar]

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