Abstract
A 71 year old man with newly diagnosed acute myelomonocytic leukaemia developed a soft tissue infection of his foot during his first course of chemotherapy. Scedosporium apiospermum was isolated from the lesion, which resolved rapidly on treatment with intravenous amphotericin B despite being resistant in vitro to this agent. This observation suggests that sensitivity testing of S apiospermum should be interpreted with caution and that clinical response may be a better indicator of outcome.
Full text
PDF

Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Mesnard R., Lamy T., Dauriac C., Le Prise P. Y. Lung abscess due to Pseudallescheria boydii in the course of acute leukaemia. Report of a case and review of the literature. Acta Haematol. 1992;87(1-2):78–82. doi: 10.1159/000204722. [DOI] [PubMed] [Google Scholar]
- Pether J. V., Jones W., Greatorex F. B., Bunting W. Acute pyogenic Pseudallescheria boydii foot infection sequentially treated with miconazole and itraconazole. J Infect. 1992 Nov;25(3):335–336. doi: 10.1016/0163-4453(92)91799-h. [DOI] [PubMed] [Google Scholar]
- Pfaller M. A., Rinaldi M. G. Antifungal susceptibility testing. Current state of technology, limitations, and standardization. Infect Dis Clin North Am. 1993 Jun;7(2):435–444. [PubMed] [Google Scholar]
- Rotowa N. A., Shadomy H. J., Shadomy S. In vitro activities of polyene and imidazole antifungal agents against unusual opportunistic fungal pathogens. Mycoses. 1990 Apr;33(4):203–211. doi: 10.1111/myc.1990.33.4.203. [DOI] [PubMed] [Google Scholar]
- Travis L. B., Roberts G. D., Wilson W. R. Clinical significance of Pseudallescheria boydii: a review of 10 years' experience. Mayo Clin Proc. 1985 Aug;60(8):531–537. doi: 10.1016/s0025-6196(12)60571-0. [DOI] [PubMed] [Google Scholar]
- Welty F. K., McLeod G. X., Ezratty C., Healy R. W., Karchmer A. W. Pseudallescheria boydii endocarditis of the pulmonic valve in a liver transplant recipient. Clin Infect Dis. 1992 Nov;15(5):858–860. doi: 10.1093/clind/15.5.858. [DOI] [PubMed] [Google Scholar]