Figure 2.

Absence of dynorphin-KOR signaling in kisspeptin cells does not alter body weight or puberty onset in either sex. Mean body weights at weaning for male (n = 17-20/genotype) and female mice (n = 11-15/genotype) (A) and from PND 21 to PND 45 for both sexes (B) did not differ between genotypes. Day of preputial separation (PS) and mean body weight at PS did not differ between CON and Kiss KORKO males (C, D). Day of vaginal opening (VO) and mean body weight at VO did not differ between CON and Kiss KORKO females (E, F) nor did day of first estrus (FE) or mean body weight at FE (G, H).