Skip to main content
Scientific Reports logoLink to Scientific Reports
. 2023 Jun 2;13:9012. doi: 10.1038/s41598-023-35624-4

Ulam-Hyers stability of tuberculosis and COVID-19 co-infection model under Atangana-Baleanu fractal-fractional operator

Arunachalam Selvam 1, Sriramulu Sabarinathan 1,, Beri Venkatachalapathy Senthil Kumar 2, Haewon Byeon 3, Kamel Guedri 4, Sayed M Eldin 5,, Muhammad Ijaz Khan 6, Vediyappan Govindan 7
PMCID: PMC10237533  PMID: 37268671

Abstract

The intention of this work is to study a mathematical model for fractal-fractional tuberculosis and COVID-19 co-infection under the Atangana-Baleanu fractal-fractional operator. Firstly, we formulate the tuberculosis and COVID-19 co-infection model by considering the tuberculosis recovery individuals, the COVID-19 recovery individuals, and both disease recovery compartment in the proposed model. The fixed point approach is utilized to explore the existence and uniqueness of the solution in the suggested model. The stability analysis related to solve the Ulam-Hyers stability is also investigated. This paper is based on Lagrange’s interpolation polynomial in the numerical scheme, which is validated through a specific case with a comparative numerical analysis for different values of the fractional and fractal orders.

Subject terms: Mathematics and computing, Applied mathematics

Introduction

SARS-CoV-2 (COVID-19) erupted in Wuhan City, China, in late 2019 and evolved into a global pandemic. More than 220 countries and territories worldwide are affected by the COVID-19 pandemic, which affects every part of our daily lives. In the 21st century, human COVIDs like SARS-CoV and MERS-CoV have risen from the creature supply-induced worldwide pandemic with an alarming death rate and morbidity. The quantities of contaminated cases passing despite everything increment essentially and do not indicate a very controlled circumstance as of 25th October 2022, a total aggregate of 62,753,838 (65,782,318) contaminated (deceased) COVID-19 cases were accounted for all over the world. These are essentially partitioned into four genera: α,β,γ, and δ. If α is β-CoV for the most part, tainted vertebrates, during γ is δ-CoV turned to influence birds. Furthermore, HCoV-229E and HCoV-NL63 of α-CoVs and HCoV-HKU1, and HCoV-OC43 of β-CoVs, exhibit low pathogenicity as well as moderate respiratory side effects as typical viruses. The other two recognizable β-CoVs, like MERS-CoV and SARS-CoV display intense and dangerous respiratory illnesses1.

Tuberculosis (shortly TB) is one of the most deadly diseases. The physiology of Mycobacterium tuberculosis is the causative agent of this life-threatening disease. However, it may harm glands, bones, the brain, the kidneys and other organs. Mycobacterium tuberculosis flourished through various stages and its host then was East Africa. Early TB infection originated in East Africa 3 million years ago and it was concluded that it might have spread to early primates around then. The incidence of TB reportedly dates back over 5000 years. Globally, 1.45 million people died and more than 10 million became infected with tubercular bacilli, which made it the world’s leading infectious killer in 20182.

Ulam3, in his celebrated talk in 1940 in the mathematics club of the University of Wisconsin, presented a number of uncertain issues. The following year, Hyers4 was the first mathematician to answer Ulam’s question concerning the stability of functional equations. Along these lines, Rassias5 autonomously presented the generalization of the Hyers theorem contained in the unbounded Cauchy contrast in 1978. Following this outcome, many mathematicians have investigated the expansion of the Ulam stability with other functional and differential equations using various techniques in different directions (see also69).

The bifurcation of fractional order has also been related to practical ventures. It is extensively employed in 4D neural network incorporating two different time delays10, three triangles multi-delayed neural network11 and delayed BAM neural network12. Authors in13 proposed the interaction between the immune system and cancer cells. The tumor-immune model has been investigated from a numerical and theoretical point of view. A fractal-fractional model of tumor-immune interaction was discussed in14.

Goudiaby et al.15 observed the simple mathematical model of COVID-19 and tuberculosis co-infection with treatment for the infected. They incorporated the optimal control system into a sub-model using five control compartments. Dokuyucu and Dutta16 analyzed a model of fractional derivative type Ebola virus spread that leads to disease in Africa by using the Caputo-Fabrizio operator. They examined the numerical solutions for the proposed model by using the Adam-Basford method for the Caputo-Fabrizio fractional derivative operator.

Mekonen et al.17 examined the COVID-19 and tuberculosis co-dynamics model and a numerical simulation showed the effect of various values of fractional order and compared the sensitive parameters. In18, the authors analyzed the COVID-19 and tuberculosis co-infection of optimal control problems. Zhang et al.19 investigated the Caputo derivative fractal-fractional type, anthropogenic cutaneous leishmania model. Based on fractional derivative order, they analyzed the existence, uniqueness and Hyers-Ulam stability of the solution derived for the model (see also2023).

Aziz Khan et al.24 studied that COVID-19 disease spreads from person to person with the help of the nabla Atangana-Baleanu-Caputo fractional derivative of Ulam-Hyers stability and optimal control strategies. In recent years, many researchers have studied the fractional model of Ulam stability with fractional results and related papers (see also2530).

Amin et al.31 examined a fractal-fractional type COVID-19 model under the Atangana-Baleanue fractal-fractional operator. Then, they analyzed the existence, uniqueness and Ulam-Hyers stability of the solution derived for the model with various values of k1 and k2. Asamoah et al.32 provided the existence and uniqueness of the solutions and Ulam-Hyers stability using the fractal-fractional Atangana-Baleanu derivative for the Q fever disease of complex dynamics.

Hasib Khan et al.33 provided a fractal-fractional order TB model restricted to a case study in China. The authors derived the Ulam-Hyers stability of advanced fractal-fractional operators. Then, they used the Lagrange polynomials interpolation numerical scheme based on the obtained algorithms. In34, the authors observed the HIV-TB co-infection model using the fractional order of the Atangana-Baleanu derivative.

The objective of this study is to utilize our numerical algorithm to observe the impact of two different orders on the approximate solutions of the given model. These two orders, namely the fractal dimension and fractional order are critical components of mathematical models that use fractional orders for simulation. This study marks the initial investigation of fractal-fractional TB and COVID-19 co-infection model using advanced fractal-fractional operators, explicitly focusing on Ulam-Hyers stability. The model also provides the existence, uniqueness, and Ulam-Hyers stability of the solutions in the proposed model. Our findings from various fractional mathematical models have motivated us to enhance our numerical approaches to accommodate fractal-fractional simulations.

Basic definitions

In this segment, we will discuss some basic concepts related to the fractal-fractional operator and some known definitions that will be needed to obtain the main results of this study. Also, in this work, we assume the space {y(s)C([0,1])R} with y=maxs[0,1]|y(s)|.

Definition 1

Let yC((a,b),R) be a fractal differentiable on (ab). The fractal-fractional derivative of y(s) with fractional order 0<k11 and fractal dimension 0<k21 in the sense of Atangana-Baleanu having a generalized Mittag-Leffler type kernel can be defined as follows33:

0FFMDsk1,k2(y(s))=AB(k1)(1-k1)ddsk20sy(u)Ek1-k11-k1s-uk1du,

where AB(k1)=1-k1+k1Γ(k1) and dy(u)duk2=limsuy(s)-y(u)sk2-uk2.

Definition 2

For the same function y, considered above, the fractal-fractional integral of y(s) with fractional order 0<k11 in the sense of Atangana-Baleanu having a Mittag-Leffler type kernel can be defined as follows31:

0FFMIsk1,k2(y(s))=k1k2AB(k1)Γ(k1)0suk2-1y(u)(s-u)k1-1du+k2(1-k1)sk2-1AB(k1)y(s).

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Model formulation

This segment describes a TB and COVID-19 co-infection model based on the Atangana-Baleanu fractal-fractional operator. Our model given below is an extension of some specified in17,18 by,

  • Including the COVID-19 disease reinfection of recovered individuals; and

  • Including the TB recovery compartment, the COVID-19 recovery compartment and both diseases recovery compartments; and

  • Including the COVID-19 infection after recovery from TB and TB infection after recovery from COVID-19.

Under the schematic diagram given in Fig. 1, the TB and COVID-19 co-infection model is presented by the system of equations depicted as follows:

0FFMDsk1,k2STC(s)=π-(λT+λC+μ)STC,0FFMDsk1,k2LT(s)=λTSTC-(α1+ω1+ηλC+μ)LT,0FFMDsk1,k2IT(s)=α1LT+p1σLTC+m1τITC-(ρ1+θ1+μ+dT)IT,0FFMDsk1,k2RT(s)=ω1LT+ρ1IT-(ν1+μ)RT,0FFMDsk1,k2IRC(s)=ν1RT-(β1+μ+dC)IRC,0FFMDsk1,k2AC(s)=λCSTC-(α2+ω2+ϵλT+μ)AC,0FFMDsk1,k2IC(s)=α2AC+p2σLTC+m2τITC+rRC-(ρ2+θ2+μ+dC)IC,0FFMDsk1,k2RC(s)=ω2AC+ρ2IC-(ν2+r+μ)RC,0FFMDsk1,k2IRT(s)=ν2RC-(β2+μ+dT)IRT,0FFMDsk1,k2LTC(s)=ηλCLT+ϵλTAC-(α12+σ+μ)LTC,0FFMDsk1,k2ITC(s)=α12LTC+θ1IT+θ2IC-(τ+μ+dTC)ITC,0FFMDsk1,k2R(s)=β1IRC+β2IRT+(1-(p1+p2))σLTC+(1-(m1+m2))τITC-μR. 1

where

λT=λ1N(s)(LT+IT),λC=λ2N(s)(AC+IC+LTC+ITC),

and N(s)=STC+LT+IT+RT+IRC+AC+IC+RC+IRT+LTC+ITC+R. The initial condition of the TB and COVID-19 co-infection model becomes: STC(0)=S0TC(s), LT(0)=L0T(s), IT(0)=I0T(s), RT(0)=R0T(s), IRC(0)=I0RC(s), AC(0)=A0C(s), IRT(0)=I0RT(s), LTC(0)=L0TC(s), ITC(0)=I0TC(s), R(0)=R0(s).

Figure 1.

Figure 1

TB and COVID-19 co-infection model showing the compartments.

In model (1), the human population is divided into twelve compartments: Susceptible to both TB and COVID-19 (STC), latent level TB infected people (LT), active level TB infected people (IT), recovered from TB (RT), COVID-19 infection after recovery from TB (IRC), COVID-19 infected with asymptomatic (AC), COVID-19 infected with symptomatic (IC), recovered from COVID-19 (RC), TB infection after recovery from COVID-19 (IRT), latent TB and COVID-19 dual infected compartment (LTC), TB and COVID-19 dual infected compartment (ITC), recovered people from both diseases (R). Table 1 describes the suggested model parameters.

Table 1.

The dependent parameters description of the proposed model.

Parameters Descriptions
π Susceptible people has recruitment rate
λ1 Transmission rate of TB
λT Force of infection for TB
η Latent level TB infected becoming asymptomatic infected with COVID-19
α1 TB infected people to become infected
p1 Recovery rate for latent TB infections in LTC
m1 Recovery rate for latent TB infections in ITC
θ1 Infection rate with COVID-19 from TB individuals
λ2 Transmission rate of COVID-19
ρ1 Rate of recovered from TB infected people
ν1 Rate of COVID-19 after recovered from TB infected people
β1 Rate of recovered from TB and COVID-19
ω1 Recovery rate of latent TB infected people
dT Death rate due to TB infectives
λC Force of infection for COVID-19
ϵ Rate of asymptomatic infected with COVID-19 to becoming latent TB
α2 Asymptomatic infected people with COVID-19 to become infected
p2 Recovery rate for COVID-19 infections in LTC
m2 Recovery rate for COVID-19 infections in ITC
θ2 Infection rate with TB from COVID-19
ρ2 Rate of recovery from COVID-19
ν2 Rate of TB after recovery from COVID-19
ω2 Rate of recovered from asymptomatic infected with COVID-19
r Rate of COVID - 19 is reactivation
β2 Rate of recovered from COVID-19 and TB
dC Death rate due to the COVID-19 infectives
α12 Both diseases latent infected individuals to the co-infection class
dTC Death rate due to the co-infection of both diseases
σ Rate at which people leave the co-infection in LTC
τ Rate at which people leave the co-infected in ITC
μ Natural death rate

We assumed that the susceptible people had been recruited into the constant rate π and the susceptible class develops TB through contact with active level TB infected patients by a force of infection λT, expressed as

λT=λ1N(LT+IT).

This expression says that λ1 represents the transmission rate of TB infection. The latent TB infection is considered asymptomatic and does not spread the disease. Similarly, susceptible people acquire infection with COVID-19 following effective contact with people infected with COVID-19 at a force of infection for COVID-19 λC, given as

λC=λ2N(AC+IC+LTC+ITC).

here λ2 denotes the COVID-19 disease transmission rate. Furthermore, we considered the individuals in the latent level TB infected people compartment (LT) leave to active level TB infected people compartment (IT) at a rate of latent TB infected people to become infected α1, and to both diseases latent infection compartment at a force of infection ηλT and some component is the rate of recovered from latent TB infected people ω1. Additionally, individuals with the TB disease infection (IT) after recovering from active TB at a rate of ρ1 while the remaining component shifted to both diseases infection (ITC) at both diseases infectious rate of θ1 or TB infected people die due to the death rate of dT. The recovered from TB (RT) has left either compartment (IRC), ν1 is respectively, the rate of COVID-19 infection after recovery from TB. Then both diseases infected in latent level (IRC) move to the compartment (R) at a rate of both diseases recovered. Moreover, we considered the individuals in the asymptomatic COVID-19 compartment (AC) leave to infected COVID-19 compartment (IC) at a rate of asymptomatic COVID-19 infected people α2, and to both diseases infection a force of infection ϵλT and some component is the recovery rate of asymptomatic COVID-19 infected people ω2.

Similarly, the individuals of the COVID-19 disease infection (IC) become recovered from COVID-19 at a rate of ρ2 or shifted to both diseases infection (ITC) and both diseases are infectious at a rate of θ2 and dC respectively, COVID-19 disease death rate in this compartment. In addition, the recovered from COVID-19 (RC) has the chance to leave either compartment (IRT), respectively, at a rate of ν2. Then both latent COVID-19 and TB co-infected individuals (IRT) move to the compartment (R) at a recovery rate from COVID-19 and TB sequentially. The latent co-infection diseases population in the compartment (LTC) either progresses to the co-infection (LTC) at a rate α12. The remaining component is assumed to be shifted to either compartment at a σ as illustrated in Fig. 1. That is, the susceptible people in the compartment (LTC) move to (IT) with a rate of recovery in COVID-19 people p2σ, move to the IC with a rate of recovery in TB infected people of p1σ, and become recovered at a rate of (1-(p1+p2))σ. Moreover, we considered that both diseases dual infection ITC leave compartments (IT,IC, and R) denoted at a rate of m1τ,m2τ, or (1-(m1+m2))τ while the co-infection induced death rate is dTC. Finally, recovered from both TB and COVID-19 (R) at the rate of natural death is denoted by μ.

Existence and uniqueness results

In this segment, we utilize the fixed-point procedure to present the existence and uniqueness of the solution for the proposed model. Applying the Atangana-Baleanu fractal-fractional integral operator on the model (1) and utilizing the initial conditions, we obtain

STC(s)=STC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1[π-(λT+λC+μ)STC]du+k2(1-k1)sk2-1AB(k1)[π-(λT+λC+μ)STC], 2
LT(s)=LT(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1[λTSTC-(α1+ω1+ηλC+μ)LT]du+k2(1-k1)sk2-1AB(k1)[λTSTC-(α1+ω1+ηλC+μ)LT], 3
IT(s)=IT(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1[α1LT+p1σLTC+m1τITC-(ρ1+θ1+μ+dT)IT]du+k2(1-k1)sk2-1AB(k1)[α1LT+p1σLTC+m1τITC-(ρ1+θ1+μ+dT)IT], 4
RT(s)=RT(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1[ω1LT+ρ1IT-(ν1+μ)RT]du+k2(1-k1)sk2-1AB(k1)[ω1LT+ρ1IT-(ν1+μ)RT], 5
IRC(s)=IRC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1[ν1RT-(β1+μ+dC)IRC]du+k2(1-k1)sk2-1AB(k1)[ν1RT-(β1+μ+dC)IRC], 6
AC(s)=AC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1[λTSTC-(α2+ω2+ϵλT+μ)AC]du+k2(1-k1)sk2-1AB(k1)[λCSTC-(α2+ω2+ϵλT+μ)AC], 7
IC(s)=IC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1[α2AC+p2σLTC+m2τITC+rRC-(ρ2+θ2+μ+dC)IC]du+k2(1-k1)sk2-1AB(k1)[α2AC+p2σLTC+m2τITC+rRC-(ρ2+θ2+μ+dC)IC], 8
RC(s)=RC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1[ω2AC+ρ2IC-(ν2+r+μ)RC]du+k2(1-k1)sk2-1AB(k1)[ω2AC+ρ2IC-(ν2+r+μ)RC], 9
IRT(s)=IRT(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1[ν2RC-(β2+μ+dT)IRT]du+k2(1-k1)sk2-1AB(k1)[ν2RC-(β2+μ+dT)IRT], 10
LTC(s)=LTC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1[ηλCLT+ϵλTAC-(α12+σ+μ)LTC]du+k2(1-k1)sk2-1AB(k1)[ηλCLT+ϵλTAC-(α12+σ+μ)LTC], 11
ITC(s)=ITC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1[α12LTC+θ1IT+θ2IC-(τ+μ+dTC)ITC]du+k2(1-k1)sk2-1AB(k1)[α12LTC+θ1IT+θ2IC-(τ+μ+dTC)ITC], 12
R(s)=R(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1[β1IRC+β2IRT+(1-(p1+p2))σLTC+(1-(m1+m2))τITC-μR]du+k2(1-k1)sk2-1AB(k1)×[β1IRC+β2IRT+(1-(p1+p2))σLTC+(1-(m1+m2))τITC-μR]. 13

Let us consider the function Qi for i=1,2,...,12 or iN112, thus

Q1(s,STC)=π-(λT+λC+μ)STC,Q2(s,LT)=λTSTC-(α1+ω1+ηλC+μ)LT,Q3(s,IT)=α1LT+p1σLTC+m1τITC-(ρ1+θ1+μ+dT)IT,Q4(s,RT)=ω1LT+ρ1IT-(ν1+μ)RT,Q5(s,IRC)=ν1RT-(β1+μ+dC)IRC,Q6(s,AC)=λCSTC-(α2+ω2+ϵλT+μ)AC,Q7(s,IC)=α2AC+p2σLTC+m2τITC+rRC-(ρ2+θ2+μ+dC)IC,Q8(s,RC)=ω2AC+ρ2IC-(ν2+r+μ)RC,Q9(s,IRT)=ν2RC-(β2+μ+dT)IRT,Q10(s,LTC)=ηλCLT+ϵλTAC-(α12+p1σ+p2σ+(1-(p1+p2))σ+μ)LTC,Q11(s,ITC)=α12LTC+θ1IT+θ2IC-(m1τ+m2τ+(1-(m1+m2))τ+μ+dTC)ITC,Q12(s,R)=β1IRC+β2IRT+(1-(p1+p2))σLTC+(1-(m1+m2))τITC-μR.

(H:) For proving our results, we consider the following assumption: For the STC(s), S~TC(s), LT(s), L~T(s), IT(s), I~T(s), RT(s), R~T(s), IRC(s), I~RC(s), AC(s), A~C(s), IC(s), I~C(s), RC(s), R~C(s), IRT(s), I~RT(s), LTC(s), L~TC(s), ITC(s), I~TC(s), R(s), R~(s)L[0,1], be continuous function, such that STC(s)L1, LT(s)L2, IT(s)L3, RT(s)L4, IRC(s)L5, AC(s)L6, IC(s)L7, RC(s)L8, IRT(s)L9, LTC(s)L10, ITC(s)L11, R(s)L12 for non-negative constant L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, L11, L12>0.

Theorem 1

The Lipschitz condition is satisfy the Qi for iN112, if the assumption H is holds true and fulfills and Ψi<1, for iN112.

Proof

Now, we prove that Q1(s,STC) fulfills the Lipschitz condition. For STC(s), S~TC(s), we get

Q1(s,STC)-Q1(s,S~TC)=||π-(λT+λC+μ)STC-π-(λT+λC+μ)S~TC||,λT+λC+μSTC-S~TC,Ψ1STC-S~TC,

where, Ψ1=λT+λC+μ. Hence, Q1 satisfies the Lipschitz condition with Lipschitz constant Ψ1. Similarly, the other kernels satisfy the Lipschitz condition as follows:

Q2(s,LT)-Q2(s,L~T)Ψ2LT-L~T,Q3(s,IT)-Q3(s,I~T)Ψ3IT-I~T,Q4(s,RT)-Q4(s,R~T)Ψ4RT-R~T,Q5(s,IRC)-Q5(s,I~RC)Ψ5IRC-I~RC,Q6(s,AC)-Q6(s,A~C)Ψ6AC-A~C,Q7(s,IC)-Q7(s,I~C)Ψ7IC-I~C,Q8(s,RC)-Q8(s,R~C)Ψ8RC-R~C,Q9(s,IRT)-Q9(s,I~RT)Ψ9IRT-I~RT,Q10(s,LTC)-Q10(s,L~TC)Ψ10LTC-L~TC,Q11(s,ITC)-Q11(s,I~TC)Ψ11ITC-I~TC,Q12(s,R)-Q12(s,R~)Ψ12R-R~.

Hence, all the kernels Qi, iN112 satisfies the Lipschitz property with constant Ψi<1 for iN112. The proof is completed.

Now, Eqs. (2) to (13) can be rewrite as follows:

STC(s)=STC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q1(u,STC(u))du+k2(1-k1)AB(k1)sk2-1Q1(s,STC(s)), 14
LT(s)=LT(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q2(u,LT(u))du+k2(1-k1)AB(k1)sk2-1Q2(s,LT(s)), 15
IT(s)=IT(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q3(u,IT(u))du+k2(1-k1)AB(k1)sk2-1Q3(s,IT(s)), 16
RT(s)=RT(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q4(u,RT(u))du+k2(1-k1)AB(k1)sk2-1Q4(s,RT(s)), 17
IRC(s)=IRC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q5(u,IRC(u))du+k2(1-k1)AB(k1)sk2-1Q5(s,IRC(s)), 18
AC(s)=AC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q6(u,AC(u))du+k2(1-k1)AB(k1)sk2-1Q6(s,AC(s)), 19
IC(s)=IC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q7(u,IC(u))du+k2(1-k1)AB(k1)sk2-1Q7(s,IC(s)), 20
RC(s)=RC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q8(u,RC(u))du+k2(1-k1)AB(k1)sk2-1Q8(s,RC(s)), 21
IRT(s)=IRT(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q9(u,IRT(u))du+k2(1-k1)AB(k1)sk2-1Q9(s,IRT(s)), 22
LTC(s)=LTC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q10(u,LTC(u))du+k2(1-k1)AB(k1)sk2-1Q10(s,LTC(s)), 23
ITC(s)=ITC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q11(u,ITC(u))du+k2(1-k1)AB(k1)sk2-1Q11(s,ITC(s)), 24
R(s)=R(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q12(u,R(u))du+k2(1-k1)AB(k1)sk2-1Q12(s,R(s)), 25

together with initial conditions are given as

S0TC(s)=STC(0),L0T(s)=LT(0),I0T(s)=IT(0),R0T(s)=RT(0),I0RC(s)=IRC(0),A0C(s)=AC(0),I0C(s)=IC(0),R0C(s)=RC(0),I0RT(s)=IRT(0),L0TC(s)=LTC(0),I0TC(s)=ITC(0),R0(s)=R(0).

Now, we define the recursive formulas for the Eqs. (14)–(25) as follows:

SnTC(s)=STC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q1(u,Sn-1TC(u))du+k2(1-k1)AB(k1)sk2-1Q1(s,Sn-1TC(s)),LnT(s)=LT(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q2(u,Ln-1T(u))du+k2(1-k1)AB(k1)sk2-1Q2(s,Ln-1T(s)),InT(s)=IT(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q3(u,In-1T(u))du+k2(1-k1)AB(k1)sk2-1Q3(s,In-1T(s)),RnT(s)=RT(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q4(u,Rn-1T(u))du+k2(1-k1)AB(k1)sk2-1Q4(s,Rn-1T(s)),InRC(s)=IRC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q5(u,In-1RCus))du+k2(1-k1)AB(k1)sk2-1Q5(s,In-1RC(s)),AnC(s)=AC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q6(u,An-1C(u))du+k2(1-k1)AB(k1)sk2-1Q6(s,An-1C(s)),InC(s)=IC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q7(u,In-1C(u))du+k2(1-k1)AB(k1)sk2-1Q7(s,In-1C(s)),RnC(s)=RC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q8(u,Rn-1C(u))du+k2(1-k1)AB(k1)sk2-1Q8(s,Rn-1C(s)),InRT(s)=IRT(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q9(u,In-1RT(u))du+k2(1-k1)AB(k1)sk2-1Q9(s,In-1RT(s)),LnTC(s)=LTC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q10(u,Ln-1TC(u))du+k2(1-k1)AB(k1)sk2-1Q10(s,Ln-1TC(s)),InTC(s)=ITC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q11(u,In-1TC(u))du+k2(1-k1)AB(k1)sk2-1Q11(s,In-1TC(s)),Rn(s)=R(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q12(u,Rn-1(u))du+k2(1-k1)AB(k1)sk2-1Q12(s,Rn-1(s)).

Theorem 2

The model (1) has a solution if the following are holds true:

Δ=maxΨi<1,iN112.

Proof

We define the functions as follows:

U1n(s)=Sn+1TC(s)-STC(s),U2n(s)=Ln+1T(s)-LT(s),U3n(s)=In+1T(s)-IT(s),U4n(s)=Rn+1T(s)-RT(s),U5n(s)=In+1RC(s)-IRC(s),U6n(s)=An+1C(s)-AC(s),U7n(s)=In+1C(s)-IC(s),U8n(s)=Rn+1C(s)-RC(s),U9n(s)=In+1RT(s)-IRT(s),U10n(s)=Ln+1TC(s)-LTC(s),U11n(s)=In+1TC(s)-ITC(s),U12n(s)=Rn+1(s)-R(s).

Then, we find that

U1n(s)=k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q1(u,SnTC(u))-Q1(u,SnTC(u))du+k2(1-k1)sk2-1AB(k1)Q1(s,Sn1TC(s))-Q1(s,STC(s)),k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)Ψ1SnTC-STC,k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)nΨ1nS1TC-STC.

Similarly, we have

U2n(s)k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)nΨ2nL1T-LT,U3n(s)k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)nΨ3nI1T-IT,U4n(s)k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)nΨ4nR1T-RT,U5n(s)k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)nΨ5nI1RC-IRC,U6n(s)k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)nΨ6nA1C-AC,U7n(s)k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)nΨ7nI1C-IC,U8n(s)k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)nΨ8nR1C-RC,U9n(s)k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)nΨ9nI1RT-IRT,U10n(s)k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)nΨ10nL1TC-LTC,U11n(s)k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)nΨ11nI1TC-ITC,U12n(s)k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)nΨ12nR1-R.

Thus, from the above twelve functions, when n, then U(s)in0, for iN112 for Ψi<1, (i=1,2,...,12) which completes the proof.

Theorem 3

Due to assumption H, the model (1) has unique solution if

k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)Ψi1,fori=1,2,...,12.

Proof

We assume that another existing solution (S~TC(s),L~T(s),I~T(s),R~T(s),I~RC(s),A~C(s),I~C(s),R~C(s),I~RT(s),L~TC(s),I~TC(s),R~(s)) with initial values, such that

S~TC(s)=S~TC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q1(u,S~TC(u))du+k2(1-k1)sk2-1AB(k1)Q1(s,STC(s)).

Now, we write

STC-S~TC=k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q1(u,STC(u))-Q1(u,S~TC(u))du+k2(1-k1)sk2-1AB(k1)Q1(s,STC(s))-Q1(s,S~TC(s)),

and so

1-k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)Ψ1STC-S~TC0. 26

The above inequality (26) is true if STC-S~TC=0, then consequently, STC(s)=S~TC(s). Hence the uniqueness of solution is proved. Similarly, we applying the same process yields LT, IT, RT, IRC, AC, IC, RC, IRT, LTC, ITC and R can be proved. So, the model (1) has a unique solution.

Ulam-Hyers stability of the proposed problem

In this segment, we obtain the Ulam-Hyers stability of the proposed model (1). We state the required definition.

Definition 3

The model (1) has Ulam-Hyers stability if there exist constants Ki>0,iN112 satisfying: For every εi>0,iN112, if

0FFMDsk1,k2STC(s)-Q1(s,STC)ε1, 27
0FFMDsk1,k2LT(s)-Q2(s,LT)ε2, 28
0FFMDsk1,k2IT(s)-Q3(s,IT)ε3, 29
0FFMDsk1,k2RT(s)-Q4(s,RT)ε4, 30
0FFMDsk1,k2IRC(s)-Q5(s,IRC)ε5, 31
0FFMDsk1,k2AC(s)-Q6(s,AC)ε6, 32
0FFMDsk1,k2IC(s)-Q7(s,IC)ε7, 33
0FFMDsk1,k2RC(s)-Q8(s,RC)ε8, 34
0FFMDsk1,k2IRT(s)-Q9(s,IRT)ε9, 35
0FFMDsk1,k2LTC(s)-Q10(s,LTC)ε10, 36
0FFMDsk1,k2ITC(s)-Q11(s,ITC)ε11, 37
0FFMDsk1,k2R(s)-Q12(s,R)ε12, 38

and there exists a solution of the TB and COVID-19 model (1), S~TC(s), L~T(s), I~T(s), R~T(s), I~RC(s), A~C(s), I~C(s), R~C(s), I~RT(s), L~TC(s), I~TC(s) and R~(s) that satisfying the given model, such that

STC-S~TCK1ε1,LT-L~TK2ε2,IT-I~TK3ε3,RT-R~TK4ε4,
IRC-I~RCK5ε5,AC-A~CK6ε6,IC-I~CK7ε7,RC-R~CK8ε8,IRT-I~RTK9ε9,LTC-L~TCK10ε10,ITC-I~TCK11ε11,R-R~K12ε12.

Remark 1

Consider that the function S~TC is a solution of the first inequality (27), if a continuous function h1 exists so that

  • |h1(s)|<ε1, and

  • 0FFMDsk1,k2STC(s)=Q1(s,STC)+h1(s).

Similarly, one can indicate such a definition for each of solutions to inequalities (27) by finding hi for iN212.

Theorem 4

Under the assumption H, the model (1) is Ulam-Hyers stable.

Proof

Let ε1>0 and the function STC be arbitrary so that

0FFMDsk1,k2STC(s)-Q1(s,STC)ε1.

In view of Remark 1, we have a function h1 with |h1(s)|<ε1 satisfies

0FFMDsk1,k2STC(s)=Q1(s,STC)+h1(s).

Consequently,

STC(s)=STC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q1(u,S~TC(u))du+k2(1-k1)sk2-1AB(k1)Q1(s,STC(s))+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1h1(u)du+k2(1-k1)sk2-1AB(k1)h1(s).

Let S~TC as the unique solution of the given model, then

S~TC(s)=S~TC(0)+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q1(u,S~TC(u))du+k2(1-k1)sk2-1AB(k1)Q1(s,S~TC(s)).

Hence,

|STC(s)-S~TC(s)|k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1|Q1(u,STC(u))-Q1(u,S~TC(u))|du+k2(1-k1)sk2-1AB(k1)|Q1(s,STC(s))-Q1(s,S~TC(s))|+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1|h1(u)|du+k2(1-k1)sk2-1AB(k1)|h1(s)|,k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)Ψ1|STC-S~TC|+k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)ε1,STC-S~TCk1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)ε11-k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)Ψ1.

Then

STC-S~TCK1ε1.

here,

K1=k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)1-k1k2Γ(k2)AB(k1)Γ(k1+k2)+k2(1-k1)AB(k1)Ψ1.

Now, applying a similar approach, we have

LT-L~TK2ε2,IT-I~TK3ε3,RT-R~TK4ε4,IRC-I~RCK5ε5,AC-A~CK6ε6,IC-I~CK7ε7,RC-R~CK8ε8,IRT-I~RTK9ε9,LTC-L~TCK10ε10,ITC-I~TCK11ε11R-R~K12ε12.

Hence, we conclude the fractal-fractional model (1) is Ulam-Hyers stable. This completes the proof.

Numerical scheme

In this segment, the numerical scheme are analyzes for the proposed model (1). For the numerical scheme, we consider the equation of the Atangana-Baleanu fractional operator can also as follows:

0FFMDsk1,k2y(s)=k2sk2-1Q(s,y(s)).

Utilizing the fractal-fractional integral operator having generalized Mittag-Leffler type kernel, we obtain

y(s)=y(0)+k2(1-k1)sk2-1AB(k1)Q(s,y(s))+k1k2AB(k1)Γ(k1)0suk2-1(s-u)k1-1Q(u,y(u))du.

Now, at s=sn+1, which gives

yn+1=y(0)+k2(1-k1)snk2-1AB(k1)Q(sn,y(sn))+k1k2AB(k1)Γ(k1)0suk2-1(sn+1-u)k1-1Q(u,y(u))du, 39

which can be written as

yn+1=y(0)+(1-k1)AB(k1)U(sn,y(sn))+k1k2AB(k1)Γ(k1)γ=1n[U(sγ,y(sγ))hsγsγ+1(u-sγ-1)(sn+1-u)k1-1du-U(sγ-1,y(sγ-1))hsγsγ+1(u-sγ)(sn+1-u)k1-1du].

Utilizing the Lagrange polynomial interpolation to Eq. (39), we obtain

yn+1=y(0)+k2snk2-11-k1AB(k1)U(sn,y(sn))+k1hk1AB(k1)Γ(k1+2)γ=1n[U(sγ,y(sγ))×((n+1-γ)k1(n-γ+2+k1)-(n-γ)k1(n-γ+2+2k1))-U(sγ-1,y(sγ-1))((n+1-γ)k1+1-(n-γ+1+k1)(n-γ)k1)].

For clarity, we can write the as follows:

yn+1=y(0)+k2snk2-11-k1AB(k1)Q(sn,y(sn))+k2hk1AB(k1)Γ(k1+2)γ=1n[sγk2-1Q(sγ,y(sγ))×((n+1-γ)k1(n-γ+2+k1)-(n-γ)k1(n-γ+2+2k1))-sγ-1k2-1Q(sγ-1,y(sγ-1))((n+1-γ)k1+1-(n-γ+1+k1)(n-γ)k1)].

Thus, by assuming

y1(n,γ):=(n+1-γ)k1(n-γ+2+k1)-(n-γ)k1(n-γ+2+2k1),y2(n,γ):=(n+1-γ)k1+1-(n-γ+1+k1)(n-γ)k1,

the numerical scheme for the integral system Eqs. (2) to (13) is obtained as

STC(sn+1)=STC(0)+k2snk2-11-k1AB(k1)Q1(sn,STC(sn))+k2hk1AB(k1)Γ(k1+2)×γ=1n[sγk2-1Q1(sγ,STC(sγ))y1(n,γ)-sγ-1k2-1Q1(sγ-1,STC(sγ-1))y2(n,γ)].

Similarly, the rest of the compartments LT, IT, RT, IRC, AC, IC, RC, IRT, LTC, ITC and R we calculate the same numerical scheme as follows:

LT(sn+1)=LT(0)+k2snk2-11-k1AB(k1)Q2(sn,LT(sn))+k2hk1AB(k1)Γ(k1+2)×γ=1n[sγk2-1Q2(sγ,LT(sγ))y1(n,γ)-sγ-1k2-1Q2(sγ-1,LT(sγ-1))y2(n,γ)],IT(sn+1)=IT(0)+k2snk2-11-k1AB(k1)Q3(sn,IT(sn))+k2hk1AB(k1)Γ(k1+2)×γ=1n[sγk2-1Q3(sγ,IT(sγ))y1(n,γ)-sγ-1k2-1Q3(sγ-1,IT(sγ-1))y2(n,γ)],RT(sn+1)=RT(0)+k2snk2-11-k1AB(k1)Q4(sn,RT(sn))+k2hk1AB(k1)Γ(k1+2)×γ=1n[sγk2-1Q4(sγ,RT(sγ))y1(n,γ)-sγ-1k2-1Q4(sγ-1,RT(sγ-1))y2(n,γ)],
IRC(sn+1)=IRC(0)+k2snk2-11-k1AB(k1)Q5(sn,IRC(sn))+k2hk1AB(k1)Γ(k1+2)×γ=1n[sγk2-1Q5(sγ,IRC(sγ))y1(n,γ)-sγ-1k2-1Q5(sγ-1,IRC(sγ-1))y2(n,γ)],AC(sn+1)=AC(0)+k2snk2-11-k1AB(k1)Q6(sn,AC(sn))+k2hk1AB(k1)Γ(k1+2)×γ=1n[sγk2-1Q6(sγ,AC(sγ))y1(n,γ)-sγ-1k2-1Q6(sγ-1,AC(sγ-1))y2(n,γ)],
IC(sn+1)=IC(0)+k2snk2-11-k1AB(k1)Q7(sn,IC(sn))+k2hk1AB(k1)Γ(k1+2)×γ=1n[sγk2-1Q7(sγ,IC(sγ))y1(n,γ)-sγ-1k2-1Q7(sγ-1,IC(sγ-1))y2(n,γ)],RC(sn+1)=RC(0)+k2snk2-11-k1AB(k1)Q8(sn,RC(sn))+k2hk1AB(k1)Γ(k1+2)×γ=1n[sγk2-1Q8(sγ,RC(sγ))y1(n,γ)-sγ-1k2-1Q8(sγ-1,RC(sγ-1))y2(n,γ)],IRT(sn+1)=IRT(0)+k2snk2-11-k1AB(k1)Q9(sn,IRT(sn))+k2hk1AB(k1)Γ(k1+2)×γ=1n[sγk2-1Q9(sγ,IRT(sγ))y1(n,γ)-sγ-1k2-1Q9(sγ-1,IRT(sγ-1))y2(n,γ)],
LTC(sn+1)=LTC(0)+k2snk2-11-k1AB(k1)Q10(sn,LTC(sn))+k2hk1AB(k1)Γ(k1+2)×γ=1n[sγk2-1Q10(sγ,LTC(sγ))y1(n,γ)-sγ-1k2-1Q10(sγ-1,LTC(sγ-1))y2(n,γ)],ITC(sn+1)=ITC(0)+k2snk2-11-k1AB(k1)Q11(sn,ITC(sn))+k2hk1AB(k1)Γ(k1+2)×γ=1n[sγk2-1Q11(sγ,ITC(sγ))y1(n,γ)-sγ-1k2-1Q11(sγ-1,ITC(sγ-1))y2(n,γ)],R(sn+1)=R(0)+k2snk2-11-k1AB(k1)Q12(sn,R(sn))+k2hk1AB(k1)Γ(k1+2)×γ=1n[sγk2-1Q12(sγ,R(sγ))y1(n,γ)-sγ-1k2-1Q12(sγ-1,LT(sγ-1))y2(n,γ)].

Numerical simulation

In this segment, the numerical simulation are examines for the proposed model (1). For this model, the initial values are assumed to be STC=4605410,LT=300000,IT=235000,RT=20000,IRC=1000,AC=9600,IC=2600,RC=2200,IRT=745,LTC=1250,ITC=600 and R=125.

Moreover, we utilized the many parametric values available from17,18 and also assumed other parametric values. The parametric values are given by π=6193,λ1=0.6,λ2=0.659,α1=0.0039,α2=1.1148,α12=1.60,η=1.01,ϵ=1.06,β1=0,β2=0,ω1=0.0244,ω2=0.20,σ=0.01,τ=0.0039,ρ1=0.0031,ρ2=0.1393,r=0.32,μ=0.0012,dT=0 and ν2=0.

Figure 2 plots the graphs for TB and COVID-19 susceptible individuals against time and varying k1 and k2. This graph shows that the different values of k1 and k2 in favour of STC human individuals decrease rapidly and it comes to nearly zero in the long run. In Figs. 3 and 8, the graphs are plotted for the latent TB human population and symptomatic infected from COVID-19 against time and varying k1 and k2. We have found that the corresponding to changing k1 and k2 in favour of LT and IT human individuals decreases to nearly zero. Figures 4 and 6 shows the repercussion of active TB infectious individuals and COVID-19 infected after recovery from TB human individuals. The IT and IRC human individuals decreased by enhancing the k1 and k2 value with time, it comes to nearly zero. During this time, the recovered TB and COVID-19 also reached their maximum peak value concerning k1 and k2, as shown in Figs. 5 and 9. Then the TB and COVID-19 recovered individuals rapidly increased against time with varying values of k1 and k2. In Figs. 7 and 10, the graph represents the symptomatic infectious individuals from COVID-19 and infected with TB after recovery from COVID-19 human individuals decrease rapidly with different values of k1 and k2 in the favouring and in the long run, it comes to nearly zero.

Figure 2.

Figure 2

Susceptible to both TB and COVID-19 and time variations for varying values of k1 and k2.

Figure 3.

Figure 3

Latent level TB infected people and time variations for varying values of k1 and k2.

Figure 8.

Figure 8

Symptomatic COVID-19 infected people and time variations for varying values of k1 and k2.

Figure 4.

Figure 4

Active level TB infected people and time variations for varying values of k1 and k2.

Figure 6.

Figure 6

Infected with COVID-19 after recovering from TB people and time variations for varying values of k1 and k2.

Figure 5.

Figure 5

Recovered from TB infected people and time variations for varying values of k1 and k2.

Figure 9.

Figure 9

Recovered from COVID-19 infected people and time variations for varying values of k1 and k2.

Figure 7.

Figure 7

Asymptomatic COVID-19 infected people and time variations for varying values of k1 and k2.

Figure 10.

Figure 10

Infected with TB after recovering from COVID-19 people and time variations for varying values of k1 and k2.

In Figs. 11 and 12, the graphs are plotted for both latent TB and COVID-19 co-infection and active TB and COVID-19 co-infection individuals against time with varying values of k1 and k2. This graph shows that the different values of k1 and k2 in favour of LTC and ITC decrease to nearly zero. Finally, in Fig. 13, the graph is plotted for both disease recovered individuals against time and varying values of k1 and k2. We have found that the different values of k1 and k2 in favour of the number of recovered people are increasing. In Figs. 14 and 15, we plotted the graph of IT and RT compared to sensitive parameters infected human individuals for different values of ρ1 and varying k1 and k2 against time. Then, the number of active TB infected human individuals decreases rapidly, and recovery from TB increases with time. At the same time, we plotted the graph of IC and RC compared to sensitive parameters in reinfected human individuals for different values of ρ2 and varying k1 and k2 against time in Figs. 16 and 17. Then the symptomatic infection from COVID-19 and recovery from COVID-19 first increases at the initial stages and decreases with time, it gets very close to zero. Finally, the graphs are plotted to compare all compartments against time, with the same values of k1 and k2 (k1=k2=0.95) in Fig. 18. Further, in Fig. 19, we obtain the simulated results with the available real data COVID-19 infected Indians in World Health Organization from 01st June 2022 to 08th September 2022 for 100 days as a data case and present a graphical comparison. We fixed the parameter values in these graphical results and varied the k1 and k2. We see that the graphs of the simulated and real data curves are very close to each other in the final stage at the order of k1=k2=0.92. Our proposed model performance is good because the number of recovered people is increasing. Hence, the fractal-fractional operator is an easy tool to understand the TB and COVID-19 co-infected model.

Figure 11.

Figure 11

Both latent TB and COVID-19 co-infected people and time variations for varying values of k1 and k2.

Figure 12.

Figure 12

Both active TB and COVID-19 co-infected people and time variations for varying values of k1 and k2.

Figure 13.

Figure 13

Both TB and COVID-19 recovered people and time variations for varying values of k1 and k2.

Figure 14.

Figure 14

Comparative study of IT and time variations with k1=k2=0.95 for varying values of infection rate ρ1.

Figure 15.

Figure 15

Comparative study of RT and time variations with k1=k2=0.95 for varying values of infection rate ρ1.

Figure 16.

Figure 16

Comparative study of Ic and time variations with k1=k2=0.95 for varying values of infection rate ρ2.

Figure 17.

Figure 17

Comparative study of Rc and time variations with k1=k2=0.95 for varying values of infection rate ρ2.

Figure 18.

Figure 18

Comparative study of TB and COVID-19 co-infection population density and k1=k2=0.95 against time.

Figure 19.

Figure 19

Comparative study of simulated and real data in COVID-19 infected people and time variations for varying of k1 and k2.

Conclusions

A fractal-fractional TB and COVID-19 co-infection model is investigated in this article. Firstly, we formulated a fractal-fractional type TB and COVID-19 co-infection model to demonstrate the theoretical existence and uniqueness results under the said derivative by utilizing the fixed point approach. An examination was conducted on the criteria proposed by Ulam-Hyers stability. This paper used Lagrange polynomial interpolation to derive the numerical scheme for the TB and COVID-19 co-infection model. We can also validate the results through a numerical simulation that has been carried out for the different values for fractional order k1, fractal dimensions k2 and parameters. Based on the numerical simulation, we have a graphical explanation of the model and a comparison of the sensitive parameters. The numerical portion of the paper presents highly realistic graphs for various orders of k1 and k2. These comparative results exhibit similar patterns but with slight deviations corresponding to the specific orders of fractal-fractional derivatives. The numerical simulation shows that the fractal-fractional TB and COVID-19 model has performed very well, as the number of recovered people increases against time. To extend the research on the subject, we can use other numerical schemes and comparative analyses to the continuation of the study.

Acknowledgements

The authors would like to thank the financial support of the Deanship of Scientific Research at Umm Al-Qura University for supporting this work by Grant Code: 23UQU4331317DSR003.

Author contributions

Investigation, A.S., S.S. and B.V.S.K.; formal analysis, S.S., B.V.S.K., S.M.E, and V.G.; methodology, A.S., S.S., B.V.S.K., and M.I.K; project administration, S.S. and S.M.E.; resources, S.S.; software, A.S., K.G. and V.G.; supervision, S.S.; funding, S.M.E. and H.B.; visualization, A.S., K.G. and V.G.; writing-original draf, A.S. and S.S.; writing-review and editing, S.S., B.V.S.K., K.G., H.B., S.M.E. and M.I.K.

Data availability

All data regarding the research work is clearly mentioned in the research work.

Competing interests

The authors declare no competing interests.

Footnotes

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Contributor Information

Sriramulu Sabarinathan, Email: ssabarimaths@gmail.com.

Sayed M. Eldin, Email: sayed.eldin22@fue.edu.eg

References

  • 1.Yin Y, Wunderink RG. MERS, SARS and other coronaviruses as causes of pneumonia. Respirology. 2018;23:130–137. doi: 10.1111/resp.13196. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.World Health Organization . Global Tuberculosis Report 2013. World Health Organization; 2013. [Google Scholar]
  • 3.Ulam SM. Problems in Modern Mathematics, Science Editors, Willey, New York. Courier Corporation; 2004. [Google Scholar]
  • 4.Hyers DH. On the stability of the linear functional equation. Proc. Natl. Acad. Sci. 1941;27:222–224. doi: 10.1073/pnas.27.4.222. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Rassias TM. On the stability of the linear mapping in Banach spaces. Proc. Am. Math. Soc. 1978;72:297–300. doi: 10.1090/S0002-9939-1978-0507327-1. [DOI] [Google Scholar]
  • 6.Senthil Kumar B, Dutta H, Sabarinathan S. Fuzzy approximations of a multiplicative inverse cubic functional equation. Soft. Comput. 2020;24:13285–13292. doi: 10.1007/s00500-020-04741-x. [DOI] [Google Scholar]
  • 7.Selvan AP, Sabarinathan S, Selvam A. Approximate solution of the special type differential equation of higher order using Taylor’s series. J. Math. Comput. Sci. 2022;27:131–141. doi: 10.22436/jmcs.027.02.04. [DOI] [Google Scholar]
  • 8.Selvam, A., Sabarinathan, S., Noeiaghdam, S. & Govindan, V. Fractional Fourier transform and Ulam stability of fractional differential equation with fractional Caputo-type derivative. J. Funct. Spaces2022 (2022).
  • 9.Selvam AGM, Baleanu D, Alzabut J, Vignesh D, Abbas S. On Hyers-Ulam Mittag-Leffler stability of discrete fractional Duffing equation with application on inverted pendulum. Adv. Differ. Equ. 2020;2020:1–15. doi: 10.1186/s13662-020-02920-6. [DOI] [Google Scholar]
  • 10.Xu C, et al. New insight into bifurcation of fractional-order 4D neural networks incorporating two different time delays. Commun. Nonlinear Sci. Numer. Simul. 2023;118:107043. doi: 10.1016/j.cnsns.2022.107043. [DOI] [Google Scholar]
  • 11.Xu, C., Liu, Z., Li, P., Yan, J. & Yao, L. Bifurcation mechanism for fractional-order three-triangle multi-delayed neural networks. Neural Process. Lett. 1–27 (2022).
  • 12.Xu C, Liao M, Li P, Guo Y, Liu Z. Bifurcation properties for fractional order delayed BAM neural networks. Cogn. Comput. 2021;13:322–356. doi: 10.1007/s12559-020-09782-w. [DOI] [Google Scholar]
  • 13.Ahmad S, Ullah A, Akgül A, Baleanu D. Theoretical and numerical analysis of fractal fractional model of tumor-immune interaction with two different kernels. Alex. Eng. J. 2022;61:5735–5752. doi: 10.1016/j.aej.2021.10.065. [DOI] [Google Scholar]
  • 14.Ahmad S, Ullah A, Abdeljawad T, Akgül A, Mlaiki N. Analysis of fractal-fractional model of tumor-immune interaction. Results Phys. 2021;25:104178. doi: 10.1016/j.rinp.2021.104178. [DOI] [Google Scholar]
  • 15.Goudiaby M, et al. Optimal control analysis of a COVID-19 and tuberculosis co-dynamics model. Inform. Med. Unlocked. 2022;28:100849. doi: 10.1016/j.imu.2022.100849. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Dokuyucu MA, Dutta H. A fractional order model for Ebola virus with the new Caputo fractional derivative without singular kernel. Chaos Solitons Fractals. 2020;134:109717. doi: 10.1016/j.chaos.2020.109717. [DOI] [Google Scholar]
  • 17.Mekonen, K. G., Balcha, S. F., Obsu, L. L. & Hassen, A. Mathematical modeling and analysis of TB and COVID-19 coinfection. J. Appl. Math.2022 (2022).
  • 18.Mekonen KG, Obsu LL, Habtemichael TG. Optimal control analysis for the coinfection of COVID-19 and TB. Arab J. Basic Appl. Sci. 2022;29:175–192. doi: 10.1080/25765299.2022.2085445. [DOI] [Google Scholar]
  • 19.Zhang L, UrRahman M, Haidong Q, Arfan M, et al. Fractal-fractional anthroponotic cutaneous leishmania model study in sense of caputo derivative. Alex. Eng. J. 2022;61:4423–4433. doi: 10.1016/j.aej.2021.10.001. [DOI] [Google Scholar]
  • 20.Ali A, et al. Investigation of time-fractional numerical scheme and numerical simulation SIQR COVID-19 mathematical model with fractal-fractional Mittage-Leffler kernel. Alex. Eng. J. 2022;61:7771–7779. doi: 10.1016/j.aej.2022.01.030. [DOI] [Google Scholar]
  • 21.Arfan M, et al. Investigation of fractal-fractional order model of COVID-19 in Pakistan under Atangana-Baleanu Caputo (ABC) derivative. Results Phys. 2021;24:104046. doi: 10.1016/j.rinp.2021.104046. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 22.Kongson J, Thaiprayoon C, Neamvonk A, Alzabut J, Sudsutad W. Investigation of fractal-fractional HIV infection by evaluating the drug therapy effect in the Atangana-Baleanu sense. Math. Biosci. Eng. 2022;19:10762–10808. doi: 10.3934/mbe.2022504. [DOI] [PubMed] [Google Scholar]
  • 23.Khan FM, Ali A, Bonyah E, Khan ZU. The mathematical analysis of the new fractional order Ebola model. J. Nanomater. 2022;2022:12. doi: 10.1155/2022/4912859. [DOI] [Google Scholar]
  • 24.Khan A, Alshehri HM, Abdeljawad T, Al-Mdallal QM, Khan H. Stability analysis of fractional nabla difference COVID-19 model. Results Phys. 2021;22:103888. doi: 10.1016/j.rinp.2021.103888. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 25.Khan MA, Ullah S, Farooq M. A new fractional model for tuberculosis with relapse via Atangana-Baleanu derivative. Chaos Solitons Fractals. 2018;116:227–238. doi: 10.1016/j.chaos.2018.09.039. [DOI] [Google Scholar]
  • 26.Ahmad S, et al. Fractional order mathematical modeling of COVID-19 transmission. Chaos Solitons Fractals. 2020;139:110256. doi: 10.1016/j.chaos.2020.110256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27.Nwajeri UK, Omame A, Onyenegecha CP. Analysis of a fractional order model for HPV and CT co-infection. Results Phys. 2021;28:104643. doi: 10.1016/j.rinp.2021.104643. [DOI] [Google Scholar]
  • 28.Shen W-Y, Chu Y-M, Ur Rahman M, Mahariq I, Zeb A. Mathematical analysis of HBV and HCV co-infection model under nonsingular fractional order derivative. Results Phys. 2021;28:104582. doi: 10.1016/j.rinp.2021.104582. [DOI] [Google Scholar]
  • 29.Sivashankar M, Sabarinathan S, Govindan V, Fernandez-Gamiz U, Noeiaghdam S. Stability analysis of COVID-19 outbreak using Caputo-Fabrizio fractional differential equation. AIMS Math. 2023;8:2720–2735. doi: 10.3934/math.2023143. [DOI] [Google Scholar]
  • 30.Sivashankar M, Sabarinathan S, Nisar KS, Ravichandran C, Kumar BS. Some properties and stability of Helmholtz model involved with nonlinear fractional difference equations and its relevance with quadcopter. Chaos Solitons Fractals. 2023;168:113161. doi: 10.1016/j.chaos.2023.113161. [DOI] [Google Scholar]
  • 31.Amin M, Farman M, Akgül A, Alqahtani RT. Effect of vaccination to control COVID-19 with fractal-fractional operator. Alex. Eng. J. 2022;61:3551–3557. doi: 10.1016/j.aej.2021.09.006. [DOI] [Google Scholar]
  • 32.Asamoah JKK. Fractal-fractional model and numerical scheme based on Newton polynomial for Q fever disease under atangana-baleanu derivative. Results Phys. 2022;34:105189. doi: 10.1016/j.rinp.2022.105189. [DOI] [Google Scholar]
  • 33.Khan H, Alam K, Gulzar H, Etemad S, Rezapour S. A case study of fractal-fractional tuberculosis model in China: existence and stability theories along with numerical simulations. Math. Comput. Simul. 2022;198:455–473. doi: 10.1016/j.matcom.2022.03.009. [DOI] [Google Scholar]
  • 34.Khan H, Gómez-Aguilar J, Alkhazzan A, Khan A. A fractional order HIV-TB coinfection model with nonsingular Mittag-Leffler law. Math. Methods Appl. Sci. 2020;43:3786–3806. doi: 10.1002/mma.6155. [DOI] [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Data Availability Statement

All data regarding the research work is clearly mentioned in the research work.


Articles from Scientific Reports are provided here courtesy of Nature Publishing Group

RESOURCES