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. 2023 Jun 5;12:e82619. doi: 10.7554/eLife.82619

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© 2023, Chella Krishnan et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 1. — (A) High-resolution association mapping of 848 heart mitochondrial proteins from 72 HMDP strains to identify pQTL networks. Associations between protein abundance levels and genetic variants located within 1 Mb of the respective gene location were considered as cis-pQTLs (p<1E-05) shown along the diagonal axis and the rest were considered as trans-pQTLs (p<1E-06). Three trans-pQTL hotspots are indicated by arrows. (B) Five WGCNA modules and the respective trans-pQTL hotspots are shown. HMDP, hybrid mouse diversity panel; pQTL, protein quantitative trait locus; WGCNA, weighted gene co-expression network analysis.