The title molecules were synthesized by alkylation of 5-[(4-dimethylamino)phenyl]-1,3,4-oxadiazole-2-thiol. In the crystals, C–H⋯π interactions are observed between neighboring molecules. Hirshfeld surface analysis indicates that H⋯H and H⋯C/C⋯H interactions make the most important contributions to the crystal packing.
Keywords: synthesis; 1,3,4-oxadiazole; crystal structure; Hirshfeld surface analysis
Abstract
The title compounds were synthesized by alkylation of 5-[(4-dimethylamino)phenyl]-1,3,4-oxadiazole-2-thiol with benzyl chloride or 2-chloro-6-fluorobenzyl chloride in the presence of potassium carbonate. The yields of 2-(benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole, C17H17N3OS (I), and 2-[(2-chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole, C17H15ClFN3OS (II), were 96 and 92%, respectively. In the crystal structures of (I) and (II), C–H⋯π interactions are observed between neighboring molecules. Hirshfeld surface analysis indicates that H⋯H and H⋯C/C⋯H interactions make the most important contributions to the crystal packing.
1. Chemical context
For the synthesis of pharmacologically active heterocyclic compounds, a study of the relationship between structure and activity is of great interest. The various five-membered aromatic heterocyclic compounds have a diverse range of action. These include oxadiazoles, consisting of two carbon atoms, two nitrogen atoms and one oxygen atom, which have four different isomeric structures: 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,2,5-oxadiazole, 1,3,4-oxadiazole.
There is much information in the literature indicating that 1,3,4-oxadiazole compounds or substituted 1,3,4-oxadiazoles have a wide spectrum of biological activity (Şahin et al., 2002 ▸; Erensoy et al., 2020 ▸; Glomb & Świątek, 2021 ▸) with substituted 5-aryl-1,3,4-oxadiazole-2(3H)thiones exhibiting anti-inflammatory, anti-cancer, analgesic and anticonvulsant activity (Chen et al., 2007 ▸; Zheng et al., 2010 ▸; Mamatha et al., 2019 ▸; Pathak et al., 2020 ▸). In this article, we report the synthesis and structure of two S-derivatives of 5-aryl-1,3,4-oxadiazole-2-thiole derivatives. From the reaction of 5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole-2-thiole with benzyl chloride or 2-chloro-6-fluorobenzyl chloride, the corresponding S-products, 2-(benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (I) and 2-[(2-chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (II) were obtained in high yield.
2. Structural commentary
Compound (I) crystallizes in space group Ia. The crystal studied was refined as an inversion twin with matrix [
0 0, 0
0, 0 0
] ; the resulting BASF value is 0.43 (2). Compound (II) crystallizes in P211/c.
In compounds (I) and (II), the oxadiazole rings (centroid Cg1) are almost coplanar with the attached benzene (C1A–C6A, centroid Cg2) rings, forming dihedral angles of 3.36 (18) and 2.93 (14)°, respectively (Figs. 1 ▸ and 2 ▸). Such an arrangement of the benzene or phenyl fragment is also observed in many similar structures (Singh et al., 2007 ▸; Zareef et al., 2008 ▸; Zheng et al., 2010 ▸; Ji & Xu 2011 ▸; Zou et al., 2020 ▸). This arrangement indicates conjugation of π-electrons between the benzene and the 1,3,4-oxadiazole rings.
Figure 1.
The asymmetric unit of (I) with atom labeling. Ellipsoids represent 30% probability levels.
Figure 2.
The asymmetric unit of (II) with atom labeling. Ellipsoids represent 30% probability levels.
The bond angle C2—S1—C7B is 99.79 (16)° in (I) and 100.11 (10)° in (II). The dihedral angle subtended by the benzene (C1B–C6B, centroid Cg3) and 1,3,4-oxadiazole rings is 74.94 (10)° in (I) and 73.12 (7)°in (II).
3. Supramolecular features
In crystal structures of the title compounds, weak intermolecular contacts of the C—X⋯π type are observed. In (I), weak C7A—H7AC⋯Cg2 interactions link the molecules, forming infinite chains along the b-axis direction (Fig. 3 ▸). Between these chains, other interactions of the C7B—H7BA⋯Cg3 type are observed, which consolidate the crystal structure (Table 1 ▸). In the crystal structure of (II), the formation of an infinite chain is also observed as a result of the C2B—Cl1⋯Cg1 interaction, which links molecules along the c-axis direction (Fig. 4 ▸). Intermolecular C8A—H8AB⋯Cg3 and C7B—H7BA⋯Cg3 interactions between these chains consolidate the crystal structure (Table 2 ▸).
Figure 3.
Observed weak intermolecular C7A—H7AC⋯Cg2 interactions in the crystal structure of (I) (the molecules are linked along the b-axis direction).
Table 1. Hydrogen-bond geometry (Å, °) for (I) .
Cg2 and Cg3 are the centroids of the C1A–C6A and C1B–C6B rings, respectively.
| D—H⋯A | D—H | H⋯A | D⋯A | D—H⋯A |
|---|---|---|---|---|
| C7A—H7AC⋯Cg2i | 0.96 | 2.80 | 3.626 (4) | 145 |
| C7B—H7BA⋯Cg3ii | 0.97 | 2.93 | 3.738 (4) | 141 |
Symmetry codes: (i)
; (ii)
.
Figure 4.
Observed intermolecular C2B—Cl1⋯Cg1 interactions in the crystal structure of (II) (the molecules are linked along the c-axis direction).
Table 2. Hydrogen-bond geometry (Å, °) for (II) .
Cg1 and Cg3 are the centroids of the O1/C2/N3/N4/C5 and C1B–C6B rings, respectively.
| D—H⋯A | D—H | H⋯A | D⋯A | D—H⋯A |
|---|---|---|---|---|
| C2B—Cl1⋯Cg1i | 1.74 (1) | 3.30 (1) | 4.939 (2) | 156 (1) |
| C8A—H8AB⋯Cg3ii | 0.96 | 2.94 | 3.857 (3) | 161 |
| C7B—H7BA⋯Cg3iii | 0.97 | 2.85 | 3.674 (2) | 143 |
Symmetry codes: (i)
; (ii)
; (iii)
.
In order to visualize and quantify the intermolecular interactions in (I) and (II), a Hirshfeld surface analysis (Spackman & Jayatilaka, 2009 ▸) was performed with Crystal Explorer 21 (Spackman et al., 2021 ▸) and the associated two-dimensional fingerprint plots (McKinnon et al., 2007 ▸) generated. The Hirshfeld surfaces for the molecules in (I) and (II) are shown in Figs. 5 ▸ and 6 ▸ in which the two-dimensional fingerprint plots of the most dominant contacts are also presented.
Figure 5.
Three-dimensional Hirshfeld surfaces of compound (I) plotted over d norm in the range 0.0145 to 1.3066 a.u. Hirshfeld fingerprint plots for all contacts and decomposed into H⋯H, H⋯C/C⋯H, H⋯N/N⋯H, H⋯S/S⋯H, C⋯C and H⋯O/O⋯H contacts. d i and d e denote the closest internal and external distances (in Å) from a point on the surface.
Figure 6.
Three-dimensional Hirshfeld surfaces of the compound (II) plotted over d norm in the range −0.0964 to 1.2943 a.u. Hirshfeld fingerprint plots for all contacts and decomposed into H⋯H, H⋯C/C⋯H, H⋯N/N⋯H, H⋯F/F⋯H, H⋯S/S⋯H, H⋯Cl/Cl⋯H, H⋯O/O⋯H and C⋯C contacts. d i and d e denote the closest internal and external distances (in Å) from a point on the surface.
For structure (I), H⋯H contacts are responsible for the largest contribution (47.8%) to the Hirshfeld surface. Besides these contacts, H⋯C/C⋯H (20.5%), H⋯N/N⋯H (12.4%), H⋯S/S⋯H (7.2%), C⋯C (4.1%) and H⋯O/O⋯H (3.5%) interactions contribute significantly to the total Hirshfeld surface (Fig. 5 ▸). The contributions of other contacts are O⋯C/C⋯O (2.0%), O⋯S/S⋯O (1.3%), S⋯C/C⋯S (0.9%), N⋯C/C⋯N (0.4%) and N⋯N (0.1%).
In the structure of (II), the percentage contributions of the most significant contacts differ because of the presence of H⋯F/F⋯H and H⋯Cl/Cl⋯H interactions and amount to H⋯H (31.8%), H⋯C/C⋯H (20.0%), H⋯N/N⋯H (9.8%), H⋯F/F⋯H (7.5%), H⋯S/S⋯H (7.1%), H⋯Cl/Cl⋯H (5.7%), H⋯O/O⋯H (5.0%) and C⋯C (3.9%) (Fig. 6 ▸). The contributions of other contacts are Cl⋯C/C⋯Cl (2.8%), Cl⋯F/F⋯Cl (1.4%), N⋯S/S⋯N (1.0%), Cl⋯O/O⋯Cl (0.9%), O⋯C/C⋯O (0.4%), N⋯C/C⋯N (0.4%), S⋯Cl/Cl⋯S (0.3%), S⋯C/C⋯S (0.3%) and N⋯O/O⋯N (0.2%).
As seen from Figs. 5 ▸ and 6 ▸, the most significant contributions to the overall Hirshfeld surface in the crystal structures of (I) and (II) are from H⋯H and H⋯C/C⋯H contacts (together they amount to more than 50% for both cases).
4. Database survey
A search in the Cambridge Structural Database (CSD, version 2022.3.0; Groom et al., 2016 ▸) yielded 45 derivatives of 5-phenyl-1,3,4-oxadiazole-2-thiole, nine of which are 2-(benzylsulfanyl)-5-phenyl-1,3,4-oxadiazole derivatives, and no structure was found for a 5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole-2-thiole derivative. When searching for similar structures in the CSD, two matches were found: 2-(4-methoxyphenyl)-5-({[3-(trifluoromethyl)phenyl] methyl}sulfanyl)-1,3,4-oxadiazole (SOXGOE; Hamdani et al., 2020 ▸) and 2-benzylsulfanyl-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole (GIDKEK; Chen et al., 2007 ▸), in which the benzene rings and 1,3,4-oxadiazole fragments are arranged in a similar manner as the title compounds. However, in the structures of SOXGOE and GIGKEK, intermolecular interactions are not observed, the molecules being stabilized mainly by van der Waals forces.
5. Synthesis and crystallization
A mixture of 5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole-2-thiole (0.005 mol), benzyl chloride or 2-chloro-6-fluorobenzyl chloride (0.005 mol) and K2CO3 (0.005 mol) was boiled in 20 ml of dry acetone for 6 h. The solvent was then removed, the residue washed with water and with 2% NaOH solution to remove unreacted oxadiazolthione, and then washed with water until neutral. The resulting target products were dried in air and recrystallized from ethanol solution. Compound (I): yield 96%, m.p. 404–405 K. Compound (II): yield 92%, m.p. 406–407 K.
6. Refinement
Crystal data, data collection and structure refinement details are summarized in Table 3 ▸. H atoms were positioned geometrically (with C—H distances of 0.97 Å for CH2, 0.96 Å for CH3 and 0.93 Å for Car) and included in the refinement in a riding-motion approximation with U
iso(H) = 1.2U
eq(C) [U
iso = 1.5U
eq(C) for methyl H atoms]. For (I), the crystal studied was refined as an inversion twin with matrix [
0 0, 0
0, 0 0
] ; the resulting BASF value is 0.43 (2).
Table 3. Experimental details.
| (I) | (II) | |
|---|---|---|
| Crystal data | ||
| Chemical formula | C17H17N3OS | C17H15ClFN3OS |
| M r | 311.39 | 363.83 |
| Crystal system, space group | Monoclinic, I a | Monoclinic, P21/c |
| Temperature (K) | 297 | 296 |
| a, b, c (Å) | 16.816 (3), 4.7848 (10), 20.123 (4) | 16.308 (3), 7.9787 (16), 13.072 (3) |
| β (°) | 105.96 (3) | 103.33 (3) |
| V (Å3) | 1556.7 (6) | 1655.1 (6) |
| Z | 4 | 4 |
| Radiation type | Cu Kα | Cu Kα |
| μ (mm−1) | 1.88 | 3.40 |
| Crystal size (mm) | 0.35 × 0.20 × 0.15 | 0.30 × 0.25 × 0.15 |
| Data collection | ||
| Diffractometer | XtaLAB Synergy, Single source at home/near, HyPix3000 | XtaLAB Synergy, Single source at home/near, HyPix3000 |
| Absorption correction | Multi-scan (SADABS; Krause et al., 2015 ▸) | Multi-scan (SADABS; Krause et al., 2015 ▸) |
| T min, T max | 0.749, 1.000 | 0.704, 1.000 |
| No. of measured, independent and observed [I > 2σ(I)] reflections | 6572, 2732, 2583 | 8579, 3181, 2771 |
| R int | 0.026 | 0.021 |
| (sin θ/λ)max (Å−1) | 0.615 | 0.615 |
| Refinement | ||
| R[F 2 > 2σ(F 2)], wR(F 2), S | 0.032, 0.089, 1.04 | 0.039, 0.106, 1.05 |
| No. of reflections | 2732 | 3181 |
| No. of parameters | 202 | 219 |
| No. of restraints | 2 | 0 |
| H-atom treatment | H-atom parameters constrained | H-atom parameters constrained |
| Δρmax, Δρmin (e Å−3) | 0.15, −0.21 | 0.18, −0.33 |
| Absolute structure | Refined as an inversion twin | – |
| Absolute structure parameter | 0.43 (2) | – |
Supplementary Material
Crystal structure: contains datablock(s) I, II, Global. DOI: 10.1107/S2056989023004164/dx2051sup1.cif
Structure factors: contains datablock(s) I. DOI: 10.1107/S2056989023004164/dx2051Isup2.hkl
Structure factors: contains datablock(s) II. DOI: 10.1107/S2056989023004164/dx2051IIsup3.hkl
Supporting information file. DOI: 10.1107/S2056989023004164/dx2051Isup4.cml
Supporting information file. DOI: 10.1107/S2056989023004164/dx2051IIsup5.cml
Additional supporting information: crystallographic information; 3D view; checkCIF report
Acknowledgments
We are especially grateful to Professor B. Tashkhodzhaev for help in discussing the results.
supplementary crystallographic information
2-(Benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (I). Crystal data
| C17H17N3OS | F(000) = 656 |
| Mr = 311.39 | Dx = 1.329 Mg m−3 |
| Monoclinic, Ia | Cu Kα radiation, λ = 1.54184 Å |
| a = 16.816 (3) Å | Cell parameters from 4218 reflections |
| b = 4.7848 (10) Å | θ = 3.0–71.2° |
| c = 20.123 (4) Å | µ = 1.88 mm−1 |
| β = 105.96 (3)° | T = 297 K |
| V = 1556.7 (6) Å3 | Prizmatic, colorless |
| Z = 4 | 0.35 × 0.20 × 0.15 mm |
2-(Benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (I). Data collection
| XtaLAB Synergy, Single source at home/near, HyPix3000 diffractometer | 2732 independent reflections |
| Radiation source: micro-focus sealed X-ray tube, PhotonJet (Cu) X-ray Source | 2583 reflections with I > 2σ(I) |
| Detector resolution: 10.0000 pixels mm-1 | Rint = 0.026 |
| ω scans | θmax = 71.5°, θmin = 4.6° |
| Absorption correction: multi-scan (SADABS; Krause et al., 2015) | h = −20→20 |
| Tmin = 0.749, Tmax = 1.000 | k = −5→5 |
| 6572 measured reflections | l = −24→24 |
2-(Benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (I). Refinement
| Refinement on F2 | Hydrogen site location: inferred from neighbouring sites |
| Least-squares matrix: full | H-atom parameters constrained |
| R[F2 > 2σ(F2)] = 0.032 | w = 1/[σ2(Fo2) + (0.0541P)2] where P = (Fo2 + 2Fc2)/3 |
| wR(F2) = 0.089 | (Δ/σ)max < 0.001 |
| S = 1.04 | Δρmax = 0.15 e Å−3 |
| 2732 reflections | Δρmin = −0.21 e Å−3 |
| 202 parameters | Absolute structure: Refined as an inversion twin |
| 2 restraints | Absolute structure parameter: 0.43 (2) |
| Primary atom site location: dual |
2-(Benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (I). Special details
| Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. |
| Refinement. Refined as a 2-component inversion twin. |
2-(Benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (I). Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)
| x | y | z | Uiso*/Ueq | ||
| S1 | 0.35188 (5) | 0.65967 (15) | 0.24394 (4) | 0.0675 (2) | |
| O1 | 0.38557 (12) | 0.2829 (4) | 0.15990 (10) | 0.0546 (4) | |
| N3 | 0.25142 (15) | 0.3621 (5) | 0.13720 (14) | 0.0607 (6) | |
| N4 | 0.26466 (15) | 0.1612 (5) | 0.09008 (14) | 0.0595 (6) | |
| N1A | 0.51675 (14) | −0.6015 (5) | −0.02778 (13) | 0.0614 (6) | |
| C2 | 0.32356 (17) | 0.4249 (6) | 0.17577 (14) | 0.0561 (6) | |
| C5 | 0.34386 (17) | 0.1194 (6) | 0.10548 (14) | 0.0518 (6) | |
| C1A | 0.38914 (15) | −0.0700 (6) | 0.07351 (13) | 0.0497 (5) | |
| C2A | 0.34682 (16) | −0.2469 (6) | 0.02095 (15) | 0.0541 (6) | |
| H2AA | 0.289305 | −0.245654 | 0.007619 | 0.065* | |
| C3A | 0.38831 (17) | −0.4238 (6) | −0.01174 (14) | 0.0543 (6) | |
| H3AA | 0.358087 | −0.539335 | −0.046814 | 0.065* | |
| C4A | 0.47522 (16) | −0.4349 (6) | 0.00637 (14) | 0.0514 (6) | |
| C5A | 0.51775 (17) | −0.2603 (6) | 0.06167 (16) | 0.0555 (6) | |
| H5AA | 0.575192 | −0.266824 | 0.076730 | 0.067* | |
| C6A | 0.47585 (16) | −0.0824 (6) | 0.09332 (14) | 0.0549 (6) | |
| H6AA | 0.505497 | 0.032849 | 0.128737 | 0.066* | |
| C7A | 0.4722 (2) | −0.7707 (7) | −0.08530 (18) | 0.0681 (8) | |
| H7AA | 0.510695 | −0.863023 | −0.105354 | 0.102* | |
| H7AB | 0.436148 | −0.653916 | −0.119410 | 0.102* | |
| H7AC | 0.439939 | −0.907932 | −0.069428 | 0.102* | |
| C8A | 0.60506 (19) | −0.6514 (7) | 0.0000 (2) | 0.0718 (9) | |
| H8AA | 0.622912 | −0.784539 | −0.028621 | 0.108* | |
| H8AB | 0.615965 | −0.723417 | 0.046118 | 0.108* | |
| H8AC | 0.634547 | −0.479131 | 0.000665 | 0.108* | |
| C1B | 0.20329 (17) | 0.5859 (6) | 0.27839 (14) | 0.0536 (6) | |
| C2B | 0.23312 (18) | 0.5105 (7) | 0.34681 (15) | 0.0605 (7) | |
| H2BA | 0.283977 | 0.579459 | 0.372557 | 0.073* | |
| C3B | 0.1890 (2) | 0.3346 (7) | 0.37792 (18) | 0.0723 (9) | |
| H3BA | 0.209881 | 0.285927 | 0.424205 | 0.087* | |
| C4B | 0.1137 (3) | 0.2317 (9) | 0.3397 (2) | 0.0826 (10) | |
| H4BA | 0.083364 | 0.114435 | 0.360365 | 0.099* | |
| C5B | 0.0837 (2) | 0.3010 (10) | 0.2720 (2) | 0.0863 (11) | |
| H5BA | 0.033294 | 0.228498 | 0.246285 | 0.104* | |
| C6B | 0.1276 (2) | 0.4787 (8) | 0.24093 (17) | 0.0710 (8) | |
| H6BA | 0.106285 | 0.526586 | 0.194651 | 0.085* | |
| C7B | 0.2500 (2) | 0.7858 (6) | 0.24513 (19) | 0.0687 (8) | |
| H7BA | 0.256392 | 0.962089 | 0.269826 | 0.082* | |
| H7BB | 0.217555 | 0.820846 | 0.197995 | 0.082* |
2-(Benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (I). Atomic displacement parameters (Å2)
| U11 | U22 | U33 | U12 | U13 | U23 | |
| S1 | 0.0666 (4) | 0.0746 (4) | 0.0645 (4) | −0.0124 (4) | 0.0234 (3) | −0.0030 (4) |
| O1 | 0.0501 (10) | 0.0581 (9) | 0.0555 (10) | −0.0021 (8) | 0.0144 (8) | 0.0069 (8) |
| N3 | 0.0516 (12) | 0.0674 (14) | 0.0641 (14) | 0.0038 (10) | 0.0177 (11) | 0.0037 (11) |
| N4 | 0.0465 (12) | 0.0681 (14) | 0.0619 (14) | 0.0035 (10) | 0.0116 (10) | 0.0036 (11) |
| N1A | 0.0471 (12) | 0.0666 (14) | 0.0680 (15) | −0.0002 (10) | 0.0114 (11) | −0.0029 (11) |
| C2 | 0.0564 (16) | 0.0568 (14) | 0.0578 (15) | −0.0004 (11) | 0.0201 (13) | 0.0116 (12) |
| C5 | 0.0471 (13) | 0.0552 (13) | 0.0515 (14) | −0.0025 (11) | 0.0108 (11) | 0.0121 (11) |
| C1A | 0.0448 (12) | 0.0528 (12) | 0.0506 (13) | 0.0000 (10) | 0.0115 (11) | 0.0127 (10) |
| C2A | 0.0398 (13) | 0.0597 (14) | 0.0601 (15) | −0.0042 (10) | 0.0092 (11) | 0.0115 (12) |
| C3A | 0.0451 (13) | 0.0565 (14) | 0.0571 (15) | −0.0047 (11) | 0.0069 (11) | 0.0061 (12) |
| C4A | 0.0438 (12) | 0.0521 (13) | 0.0556 (15) | −0.0040 (10) | 0.0091 (11) | 0.0119 (11) |
| C5A | 0.0400 (12) | 0.0612 (14) | 0.0600 (15) | −0.0034 (11) | 0.0048 (12) | 0.0073 (12) |
| C6A | 0.0469 (13) | 0.0576 (14) | 0.0552 (14) | −0.0041 (11) | 0.0058 (11) | 0.0041 (12) |
| C7A | 0.0636 (18) | 0.0708 (18) | 0.0676 (19) | −0.0046 (15) | 0.0145 (15) | −0.0064 (15) |
| C8A | 0.0473 (15) | 0.084 (2) | 0.084 (2) | 0.0032 (15) | 0.0178 (15) | −0.0042 (17) |
| C1B | 0.0555 (14) | 0.0531 (13) | 0.0541 (14) | 0.0088 (11) | 0.0184 (12) | −0.0046 (11) |
| C2B | 0.0550 (15) | 0.0725 (17) | 0.0527 (15) | −0.0006 (13) | 0.0126 (12) | −0.0028 (12) |
| C3B | 0.071 (2) | 0.089 (2) | 0.0609 (18) | 0.0056 (16) | 0.0252 (16) | 0.0073 (15) |
| C4B | 0.074 (2) | 0.101 (3) | 0.084 (2) | −0.0115 (19) | 0.042 (2) | −0.006 (2) |
| C5B | 0.0556 (18) | 0.119 (3) | 0.087 (2) | −0.0168 (18) | 0.0245 (17) | −0.027 (2) |
| C6B | 0.0580 (16) | 0.097 (2) | 0.0563 (17) | 0.0077 (16) | 0.0121 (14) | −0.0097 (16) |
| C7B | 0.083 (2) | 0.0529 (15) | 0.0729 (19) | 0.0070 (14) | 0.0255 (16) | 0.0060 (13) |
2-(Benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (I). Geometric parameters (Å, º)
| S1—C2 | 1.735 (3) | C7A—H7AA | 0.9600 |
| S1—C7B | 1.823 (4) | C7A—H7AB | 0.9600 |
| O1—C2 | 1.354 (3) | C7A—H7AC | 0.9600 |
| O1—C5 | 1.371 (3) | C8A—H8AA | 0.9600 |
| N3—C2 | 1.283 (4) | C8A—H8AB | 0.9600 |
| N3—N4 | 1.410 (4) | C8A—H8AC | 0.9600 |
| N4—C5 | 1.297 (4) | C1B—C2B | 1.378 (4) |
| N1A—C4A | 1.364 (4) | C1B—C6B | 1.387 (5) |
| N1A—C7A | 1.442 (4) | C1B—C7B | 1.506 (5) |
| N1A—C8A | 1.455 (4) | C2B—C3B | 1.381 (5) |
| C5—C1A | 1.444 (4) | C2B—H2BA | 0.9300 |
| C1A—C2A | 1.388 (4) | C3B—C4B | 1.379 (6) |
| C1A—C6A | 1.403 (4) | C3B—H3BA | 0.9300 |
| C2A—C3A | 1.374 (4) | C4B—C5B | 1.358 (7) |
| C2A—H2AA | 0.9300 | C4B—H4BA | 0.9300 |
| C3A—C4A | 1.407 (4) | C5B—C6B | 1.383 (6) |
| C3A—H3AA | 0.9300 | C5B—H5BA | 0.9300 |
| C4A—C5A | 1.418 (4) | C6B—H6BA | 0.9300 |
| C5A—C6A | 1.369 (4) | C7B—H7BA | 0.9700 |
| C5A—H5AA | 0.9300 | C7B—H7BB | 0.9700 |
| C6A—H6AA | 0.9300 | ||
| C2—S1—C7B | 99.79 (16) | N1A—C7A—H7AC | 109.5 |
| C2—O1—C5 | 102.5 (2) | H7AA—C7A—H7AC | 109.5 |
| C2—N3—N4 | 105.6 (2) | H7AB—C7A—H7AC | 109.5 |
| C5—N4—N3 | 106.6 (2) | N1A—C8A—H8AA | 109.5 |
| C4A—N1A—C7A | 120.5 (2) | N1A—C8A—H8AB | 109.5 |
| C4A—N1A—C8A | 120.8 (3) | H8AA—C8A—H8AB | 109.5 |
| C7A—N1A—C8A | 117.8 (3) | N1A—C8A—H8AC | 109.5 |
| N3—C2—O1 | 113.6 (3) | H8AA—C8A—H8AC | 109.5 |
| N3—C2—S1 | 129.6 (2) | H8AB—C8A—H8AC | 109.5 |
| O1—C2—S1 | 116.7 (2) | C2B—C1B—C6B | 118.3 (3) |
| N4—C5—O1 | 111.6 (3) | C2B—C1B—C7B | 121.3 (3) |
| N4—C5—C1A | 128.5 (3) | C6B—C1B—C7B | 120.4 (3) |
| O1—C5—C1A | 119.8 (2) | C1B—C2B—C3B | 121.3 (3) |
| C2A—C1A—C6A | 117.7 (3) | C1B—C2B—H2BA | 119.3 |
| C2A—C1A—C5 | 120.0 (2) | C3B—C2B—H2BA | 119.3 |
| C6A—C1A—C5 | 122.3 (2) | C4B—C3B—C2B | 119.3 (3) |
| C3A—C2A—C1A | 121.3 (3) | C4B—C3B—H3BA | 120.3 |
| C3A—C2A—H2AA | 119.4 | C2B—C3B—H3BA | 120.3 |
| C1A—C2A—H2AA | 119.4 | C5B—C4B—C3B | 120.2 (4) |
| C2A—C3A—C4A | 121.8 (3) | C5B—C4B—H4BA | 119.9 |
| C2A—C3A—H3AA | 119.1 | C3B—C4B—H4BA | 119.9 |
| C4A—C3A—H3AA | 119.1 | C4B—C5B—C6B | 120.4 (4) |
| N1A—C4A—C3A | 122.1 (3) | C4B—C5B—H5BA | 119.8 |
| N1A—C4A—C5A | 121.5 (2) | C6B—C5B—H5BA | 119.8 |
| C3A—C4A—C5A | 116.4 (3) | C5B—C6B—C1B | 120.4 (3) |
| C6A—C5A—C4A | 121.2 (3) | C5B—C6B—H6BA | 119.8 |
| C6A—C5A—H5AA | 119.4 | C1B—C6B—H6BA | 119.8 |
| C4A—C5A—H5AA | 119.4 | C1B—C7B—S1 | 113.7 (2) |
| C5A—C6A—C1A | 121.4 (3) | C1B—C7B—H7BA | 108.8 |
| C5A—C6A—H6AA | 119.3 | S1—C7B—H7BA | 108.8 |
| C1A—C6A—H6AA | 119.3 | C1B—C7B—H7BB | 108.8 |
| N1A—C7A—H7AA | 109.5 | S1—C7B—H7BB | 108.8 |
| N1A—C7A—H7AB | 109.5 | H7BA—C7B—H7BB | 107.7 |
| H7AA—C7A—H7AB | 109.5 | ||
| C2—N3—N4—C5 | 0.8 (3) | C7A—N1A—C4A—C5A | −178.0 (3) |
| N4—N3—C2—O1 | −0.6 (3) | C8A—N1A—C4A—C5A | 13.0 (4) |
| N4—N3—C2—S1 | 179.7 (2) | C2A—C3A—C4A—N1A | −177.2 (3) |
| C5—O1—C2—N3 | 0.2 (3) | C2A—C3A—C4A—C5A | 2.0 (4) |
| C5—O1—C2—S1 | 179.95 (18) | N1A—C4A—C5A—C6A | 176.4 (3) |
| C7B—S1—C2—N3 | 0.7 (3) | C3A—C4A—C5A—C6A | −2.8 (4) |
| C7B—S1—C2—O1 | −179.1 (2) | C4A—C5A—C6A—C1A | 1.5 (4) |
| N3—N4—C5—O1 | −0.8 (3) | C2A—C1A—C6A—C5A | 0.6 (4) |
| N3—N4—C5—C1A | 178.9 (2) | C5—C1A—C6A—C5A | −179.0 (3) |
| C2—O1—C5—N4 | 0.4 (3) | C6B—C1B—C2B—C3B | −0.5 (4) |
| C2—O1—C5—C1A | −179.3 (2) | C7B—C1B—C2B—C3B | 177.8 (3) |
| N4—C5—C1A—C2A | −3.2 (4) | C1B—C2B—C3B—C4B | 0.2 (5) |
| O1—C5—C1A—C2A | 176.4 (2) | C2B—C3B—C4B—C5B | 0.6 (6) |
| N4—C5—C1A—C6A | 176.4 (3) | C3B—C4B—C5B—C6B | −1.0 (6) |
| O1—C5—C1A—C6A | −4.0 (4) | C4B—C5B—C6B—C1B | 0.7 (6) |
| C6A—C1A—C2A—C3A | −1.5 (4) | C2B—C1B—C6B—C5B | 0.1 (5) |
| C5—C1A—C2A—C3A | 178.2 (2) | C7B—C1B—C6B—C5B | −178.3 (3) |
| C1A—C2A—C3A—C4A | 0.1 (4) | C2B—C1B—C7B—S1 | 61.9 (3) |
| C7A—N1A—C4A—C3A | 1.1 (4) | C6B—C1B—C7B—S1 | −119.8 (3) |
| C8A—N1A—C4A—C3A | −167.9 (3) | C2—S1—C7B—C1B | 77.7 (3) |
2-(Benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (I). Hydrogen-bond geometry (Å, º)
Cg2 and Cg3 are the centroids of the C1A–C6A and C1B–C6B rings, respectively.
| D—H···A | D—H | H···A | D···A | D—H···A |
| C7A—H7AC···Cg2i | 0.96 | 2.80 | 3.626 (4) | 145 |
| C7B—H7BA···Cg3ii | 0.97 | 2.93 | 3.738 (4) | 141 |
Symmetry codes: (i) x, y−1, z; (ii) x, y+1, z.
2-[(2-Chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (II). Crystal data
| C17H15ClFN3OS | F(000) = 752 |
| Mr = 363.83 | Dx = 1.460 Mg m−3 |
| Monoclinic, P21/c | Cu Kα radiation, λ = 1.54184 Å |
| a = 16.308 (3) Å | Cell parameters from 4884 reflections |
| b = 7.9787 (16) Å | θ = 2.8–70.7° |
| c = 13.072 (3) Å | µ = 3.40 mm−1 |
| β = 103.33 (3)° | T = 296 K |
| V = 1655.1 (6) Å3 | Prizmatic, colorless |
| Z = 4 | 0.30 × 0.25 × 0.15 mm |
2-[(2-Chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (II). Data collection
| XtaLAB Synergy, Single source at home/near, HyPix3000 diffractometer | 3181 independent reflections |
| Radiation source: micro-focus sealed X-ray tube, PhotonJet (Cu) X-ray Source | 2771 reflections with I > 2σ(I) |
| Detector resolution: 10.0000 pixels mm-1 | Rint = 0.021 |
| ω scans | θmax = 71.5°, θmin = 2.8° |
| Absorption correction: multi-scan (SADABS; Krause et al., 2015) | h = −19→19 |
| Tmin = 0.704, Tmax = 1.000 | k = −9→9 |
| 8579 measured reflections | l = −14→15 |
2-[(2-Chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (II). Refinement
| Refinement on F2 | Primary atom site location: dual |
| Least-squares matrix: full | Hydrogen site location: inferred from neighbouring sites |
| R[F2 > 2σ(F2)] = 0.039 | H-atom parameters constrained |
| wR(F2) = 0.106 | w = 1/[σ2(Fo2) + (0.0548P)2 + 0.3561P] where P = (Fo2 + 2Fc2)/3 |
| S = 1.05 | (Δ/σ)max = 0.001 |
| 3181 reflections | Δρmax = 0.18 e Å−3 |
| 219 parameters | Δρmin = −0.33 e Å−3 |
| 0 restraints |
2-[(2-Chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (II). Special details
| Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. |
2-[(2-Chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (II). Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)
| x | y | z | Uiso*/Ueq | ||
| S1 | 0.70024 (3) | 0.25638 (6) | 0.67262 (4) | 0.05766 (17) | |
| F1 | 0.53784 (8) | 0.62390 (19) | 0.74016 (9) | 0.0710 (4) | |
| Cl1 | 0.65329 (4) | 0.42921 (8) | 0.43372 (4) | 0.07189 (19) | |
| N3 | 0.70438 (10) | 0.4438 (2) | 0.85013 (13) | 0.0575 (4) | |
| N4 | 0.76430 (11) | 0.4635 (2) | 0.94693 (13) | 0.0591 (4) | |
| N4A | 1.13318 (11) | 0.2937 (3) | 1.24513 (14) | 0.0645 (5) | |
| O1 | 0.81509 (8) | 0.28552 (16) | 0.84836 (9) | 0.0484 (3) | |
| C2 | 0.73729 (11) | 0.3394 (2) | 0.79712 (14) | 0.0469 (4) | |
| C5 | 0.82736 (11) | 0.3695 (2) | 0.94229 (13) | 0.0459 (4) | |
| C1A | 0.90528 (11) | 0.3437 (2) | 1.02033 (13) | 0.0458 (4) | |
| C2A | 0.91795 (13) | 0.4247 (3) | 1.11650 (15) | 0.0569 (5) | |
| H2AA | 0.875254 | 0.491431 | 1.130992 | 0.068* | |
| C3A | 0.99218 (13) | 0.4085 (3) | 1.19079 (15) | 0.0583 (5) | |
| H3AA | 0.998800 | 0.464500 | 1.254560 | 0.070* | |
| C4A | 1.05833 (11) | 0.3090 (2) | 1.17239 (14) | 0.0490 (4) | |
| C5A | 1.04385 (13) | 0.2249 (3) | 1.07595 (16) | 0.0583 (5) | |
| H5AA | 1.085423 | 0.154883 | 1.061691 | 0.070* | |
| C6A | 0.96948 (13) | 0.2437 (3) | 1.00180 (15) | 0.0560 (5) | |
| H6AA | 0.962246 | 0.187883 | 0.937881 | 0.067* | |
| C7A | 1.14655 (15) | 0.3781 (4) | 1.34498 (18) | 0.0783 (7) | |
| H7AA | 1.103965 | 0.344344 | 1.380639 | 0.118* | |
| H7AB | 1.143475 | 0.497119 | 1.333810 | 0.118* | |
| H7AC | 1.201117 | 0.349276 | 1.387036 | 0.118* | |
| C8A | 1.20022 (14) | 0.1914 (3) | 1.2238 (2) | 0.0734 (6) | |
| H8AA | 1.180549 | 0.078396 | 1.209806 | 0.110* | |
| H8AB | 1.247110 | 0.192586 | 1.283686 | 0.110* | |
| H8AC | 1.217624 | 0.234985 | 1.163709 | 0.110* | |
| C1B | 0.59678 (10) | 0.5336 (2) | 0.60183 (12) | 0.0413 (4) | |
| C2B | 0.62301 (10) | 0.5823 (2) | 0.51172 (13) | 0.0447 (4) | |
| C3B | 0.62432 (12) | 0.7473 (3) | 0.48082 (16) | 0.0555 (5) | |
| H3BA | 0.643266 | 0.775274 | 0.421154 | 0.067* | |
| C4B | 0.59745 (14) | 0.8693 (3) | 0.53885 (19) | 0.0641 (6) | |
| H4BA | 0.598734 | 0.980957 | 0.518853 | 0.077* | |
| C5B | 0.56857 (13) | 0.8285 (3) | 0.62650 (18) | 0.0618 (5) | |
| H5BA | 0.549420 | 0.911110 | 0.665483 | 0.074* | |
| C6B | 0.56865 (11) | 0.6628 (3) | 0.65515 (14) | 0.0487 (4) | |
| C7B | 0.59662 (12) | 0.3548 (2) | 0.63726 (16) | 0.0537 (5) | |
| H7BA | 0.561130 | 0.289986 | 0.581406 | 0.064* | |
| H7BB | 0.571488 | 0.350251 | 0.697611 | 0.064* |
2-[(2-Chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (II). Atomic displacement parameters (Å2)
| U11 | U22 | U33 | U12 | U13 | U23 | |
| S1 | 0.0609 (3) | 0.0489 (3) | 0.0553 (3) | 0.0077 (2) | −0.0030 (2) | −0.0039 (2) |
| F1 | 0.0611 (7) | 0.1044 (10) | 0.0511 (6) | 0.0122 (7) | 0.0199 (5) | −0.0031 (6) |
| Cl1 | 0.0721 (4) | 0.0899 (4) | 0.0532 (3) | 0.0172 (3) | 0.0134 (2) | −0.0173 (3) |
| N3 | 0.0510 (9) | 0.0600 (10) | 0.0562 (9) | 0.0113 (8) | 0.0010 (7) | 0.0001 (8) |
| N4 | 0.0550 (9) | 0.0651 (10) | 0.0532 (9) | 0.0145 (8) | 0.0046 (7) | −0.0054 (8) |
| N4A | 0.0483 (9) | 0.0850 (12) | 0.0551 (9) | 0.0034 (9) | 0.0013 (7) | 0.0009 (9) |
| O1 | 0.0478 (7) | 0.0486 (7) | 0.0460 (6) | 0.0071 (5) | 0.0050 (5) | −0.0008 (5) |
| C2 | 0.0466 (9) | 0.0408 (9) | 0.0500 (9) | 0.0025 (8) | 0.0043 (8) | 0.0053 (7) |
| C5 | 0.0481 (10) | 0.0438 (9) | 0.0455 (9) | 0.0032 (8) | 0.0102 (7) | 0.0005 (7) |
| C1A | 0.0454 (9) | 0.0463 (9) | 0.0447 (9) | 0.0038 (8) | 0.0088 (7) | 0.0015 (7) |
| C2A | 0.0552 (11) | 0.0628 (12) | 0.0518 (10) | 0.0154 (9) | 0.0107 (9) | −0.0077 (9) |
| C3A | 0.0636 (12) | 0.0639 (12) | 0.0449 (10) | 0.0076 (10) | 0.0072 (9) | −0.0093 (9) |
| C4A | 0.0459 (10) | 0.0549 (10) | 0.0454 (9) | −0.0020 (8) | 0.0093 (7) | 0.0066 (8) |
| C5A | 0.0504 (11) | 0.0717 (13) | 0.0524 (10) | 0.0171 (10) | 0.0110 (9) | −0.0048 (9) |
| C6A | 0.0560 (11) | 0.0650 (12) | 0.0455 (10) | 0.0124 (9) | 0.0087 (9) | −0.0080 (9) |
| C7A | 0.0620 (13) | 0.109 (2) | 0.0565 (12) | −0.0168 (14) | −0.0021 (10) | −0.0042 (13) |
| C8A | 0.0484 (11) | 0.0855 (16) | 0.0824 (15) | 0.0075 (11) | 0.0071 (10) | 0.0184 (13) |
| C1B | 0.0319 (8) | 0.0469 (9) | 0.0415 (8) | −0.0017 (7) | 0.0008 (6) | −0.0021 (7) |
| C2B | 0.0340 (8) | 0.0545 (10) | 0.0423 (8) | 0.0003 (7) | 0.0018 (7) | −0.0044 (7) |
| C3B | 0.0431 (10) | 0.0641 (12) | 0.0553 (11) | −0.0049 (9) | 0.0031 (8) | 0.0125 (9) |
| C4B | 0.0555 (12) | 0.0470 (11) | 0.0818 (15) | −0.0011 (9) | −0.0005 (10) | 0.0053 (10) |
| C5B | 0.0522 (11) | 0.0545 (11) | 0.0731 (13) | 0.0080 (9) | 0.0032 (10) | −0.0161 (10) |
| C6B | 0.0367 (8) | 0.0633 (11) | 0.0437 (9) | 0.0029 (8) | 0.0048 (7) | −0.0064 (8) |
| C7B | 0.0448 (10) | 0.0522 (10) | 0.0589 (11) | −0.0064 (8) | 0.0014 (8) | 0.0019 (8) |
2-[(2-Chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (II). Geometric parameters (Å, º)
| S1—C2 | 1.7317 (19) | C5A—H5AA | 0.9300 |
| S1—C7B | 1.824 (2) | C6A—H6AA | 0.9300 |
| F1—C6B | 1.357 (2) | C7A—H7AA | 0.9600 |
| Cl1—C2B | 1.7346 (18) | C7A—H7AB | 0.9600 |
| N3—C2 | 1.278 (2) | C7A—H7AC | 0.9600 |
| N3—N4 | 1.418 (2) | C8A—H8AA | 0.9600 |
| N4—C5 | 1.286 (2) | C8A—H8AB | 0.9600 |
| N4A—C4A | 1.369 (2) | C8A—H8AC | 0.9600 |
| N4A—C7A | 1.440 (3) | C1B—C6B | 1.381 (2) |
| N4A—C8A | 1.442 (3) | C1B—C2B | 1.398 (2) |
| O1—C2 | 1.361 (2) | C1B—C7B | 1.500 (2) |
| O1—C5 | 1.372 (2) | C2B—C3B | 1.378 (3) |
| C5—C1A | 1.449 (2) | C3B—C4B | 1.367 (3) |
| C1A—C6A | 1.382 (3) | C3B—H3BA | 0.9300 |
| C1A—C2A | 1.386 (3) | C4B—C5B | 1.375 (3) |
| C2A—C3A | 1.372 (3) | C4B—H4BA | 0.9300 |
| C2A—H2AA | 0.9300 | C5B—C6B | 1.374 (3) |
| C3A—C4A | 1.404 (3) | C5B—H5BA | 0.9300 |
| C3A—H3AA | 0.9300 | C7B—H7BA | 0.9700 |
| C4A—C5A | 1.399 (3) | C7B—H7BB | 0.9700 |
| C5A—C6A | 1.375 (3) | ||
| C2—S1—C7B | 100.11 (10) | N4A—C7A—H7AC | 109.5 |
| C2—N3—N4 | 105.48 (15) | H7AA—C7A—H7AC | 109.5 |
| C5—N4—N3 | 106.70 (15) | H7AB—C7A—H7AC | 109.5 |
| C4A—N4A—C7A | 120.80 (19) | N4A—C8A—H8AA | 109.5 |
| C4A—N4A—C8A | 120.70 (19) | N4A—C8A—H8AB | 109.5 |
| C7A—N4A—C8A | 118.50 (19) | H8AA—C8A—H8AB | 109.5 |
| C2—O1—C5 | 102.31 (14) | N4A—C8A—H8AC | 109.5 |
| N3—C2—O1 | 113.54 (16) | H8AA—C8A—H8AC | 109.5 |
| N3—C2—S1 | 131.27 (14) | H8AB—C8A—H8AC | 109.5 |
| O1—C2—S1 | 115.19 (13) | C6B—C1B—C2B | 114.82 (16) |
| N4—C5—O1 | 111.96 (16) | C6B—C1B—C7B | 121.99 (17) |
| N4—C5—C1A | 129.11 (17) | C2B—C1B—C7B | 123.18 (16) |
| O1—C5—C1A | 118.93 (15) | C3B—C2B—C1B | 122.74 (17) |
| C6A—C1A—C2A | 117.89 (17) | C3B—C2B—Cl1 | 118.33 (15) |
| C6A—C1A—C5 | 122.38 (16) | C1B—C2B—Cl1 | 118.91 (14) |
| C2A—C1A—C5 | 119.70 (17) | C4B—C3B—C2B | 119.26 (19) |
| C3A—C2A—C1A | 121.37 (18) | C4B—C3B—H3BA | 120.4 |
| C3A—C2A—H2AA | 119.3 | C2B—C3B—H3BA | 120.4 |
| C1A—C2A—H2AA | 119.3 | C3B—C4B—C5B | 120.6 (2) |
| C2A—C3A—C4A | 121.29 (18) | C3B—C4B—H4BA | 119.7 |
| C2A—C3A—H3AA | 119.4 | C5B—C4B—H4BA | 119.7 |
| C4A—C3A—H3AA | 119.4 | C6B—C5B—C4B | 118.43 (19) |
| N4A—C4A—C5A | 121.42 (18) | C6B—C5B—H5BA | 120.8 |
| N4A—C4A—C3A | 121.92 (18) | C4B—C5B—H5BA | 120.8 |
| C5A—C4A—C3A | 116.66 (17) | F1—C6B—C5B | 117.80 (18) |
| C6A—C5A—C4A | 121.41 (18) | F1—C6B—C1B | 118.12 (18) |
| C6A—C5A—H5AA | 119.3 | C5B—C6B—C1B | 124.07 (18) |
| C4A—C5A—H5AA | 119.3 | C1B—C7B—S1 | 114.87 (13) |
| C5A—C6A—C1A | 121.35 (18) | C1B—C7B—H7BA | 108.6 |
| C5A—C6A—H6AA | 119.3 | S1—C7B—H7BA | 108.6 |
| C1A—C6A—H6AA | 119.3 | C1B—C7B—H7BB | 108.6 |
| N4A—C7A—H7AA | 109.5 | S1—C7B—H7BB | 108.6 |
| N4A—C7A—H7AB | 109.5 | H7BA—C7B—H7BB | 107.5 |
| H7AA—C7A—H7AB | 109.5 | ||
| C2—N3—N4—C5 | 0.2 (2) | C2A—C3A—C4A—C5A | −1.4 (3) |
| N4—N3—C2—O1 | −0.4 (2) | N4A—C4A—C5A—C6A | −178.3 (2) |
| N4—N3—C2—S1 | 179.84 (15) | C3A—C4A—C5A—C6A | 2.1 (3) |
| C5—O1—C2—N3 | 0.4 (2) | C4A—C5A—C6A—C1A | −1.3 (3) |
| C5—O1—C2—S1 | −179.82 (12) | C2A—C1A—C6A—C5A | −0.2 (3) |
| C7B—S1—C2—N3 | −1.9 (2) | C5—C1A—C6A—C5A | 178.09 (19) |
| C7B—S1—C2—O1 | 178.28 (13) | C6B—C1B—C2B—C3B | 2.8 (2) |
| N3—N4—C5—O1 | 0.0 (2) | C7B—C1B—C2B—C3B | −178.83 (17) |
| N3—N4—C5—C1A | 179.96 (18) | C6B—C1B—C2B—Cl1 | −175.93 (12) |
| C2—O1—C5—N4 | −0.2 (2) | C7B—C1B—C2B—Cl1 | 2.5 (2) |
| C2—O1—C5—C1A | 179.82 (16) | C1B—C2B—C3B—C4B | −1.3 (3) |
| N4—C5—C1A—C6A | −176.9 (2) | Cl1—C2B—C3B—C4B | 177.37 (15) |
| O1—C5—C1A—C6A | 3.1 (3) | C2B—C3B—C4B—C5B | −0.7 (3) |
| N4—C5—C1A—C2A | 1.4 (3) | C3B—C4B—C5B—C6B | 1.0 (3) |
| O1—C5—C1A—C2A | −178.60 (17) | C4B—C5B—C6B—F1 | −178.26 (17) |
| C6A—C1A—C2A—C3A | 0.9 (3) | C4B—C5B—C6B—C1B | 0.6 (3) |
| C5—C1A—C2A—C3A | −177.46 (19) | C2B—C1B—C6B—F1 | 176.46 (14) |
| C1A—C2A—C3A—C4A | −0.1 (3) | C7B—C1B—C6B—F1 | −2.0 (2) |
| C7A—N4A—C4A—C5A | −178.7 (2) | C2B—C1B—C6B—C5B | −2.4 (2) |
| C8A—N4A—C4A—C5A | 0.8 (3) | C7B—C1B—C6B—C5B | 179.15 (17) |
| C7A—N4A—C4A—C3A | 0.9 (3) | C6B—C1B—C7B—S1 | −118.50 (17) |
| C8A—N4A—C4A—C3A | −179.6 (2) | C2B—C1B—C7B—S1 | 63.2 (2) |
| C2A—C3A—C4A—N4A | 179.0 (2) | C2—S1—C7B—C1B | 78.87 (15) |
2-[(2-Chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole (II). Hydrogen-bond geometry (Å, º)
Cg1 and Cg3 are the centroids of the O1/C2/N3/N4/C5 and C1B–C6B rings, respectively.
| D—H···A | D—H | H···A | D···A | D—H···A |
| C2B—Cl1···Cg1i | 1.74 (1) | 3.30 (1) | 4.939 (2) | 156 (1) |
| C8A—H8AB···Cg3ii | 0.96 | 2.94 | 3.857 (3) | 161 |
| C7B—H7BA···Cg3iii | 0.97 | 2.85 | 3.674 (2) | 143 |
Symmetry codes: (i) x, −y−1/2, z−3/2; (ii) −x+2, −y+1, −z+2; (iii) −x+1, −y+1, −z+1.
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Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Supplementary Materials
Crystal structure: contains datablock(s) I, II, Global. DOI: 10.1107/S2056989023004164/dx2051sup1.cif
Structure factors: contains datablock(s) I. DOI: 10.1107/S2056989023004164/dx2051Isup2.hkl
Structure factors: contains datablock(s) II. DOI: 10.1107/S2056989023004164/dx2051IIsup3.hkl
Supporting information file. DOI: 10.1107/S2056989023004164/dx2051Isup4.cml
Supporting information file. DOI: 10.1107/S2056989023004164/dx2051IIsup5.cml
Additional supporting information: crystallographic information; 3D view; checkCIF report