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. 1990 Feb;63(2):78–81. doi: 10.1136/hrt.63.2.78

High density lipoprotein cholesterol and triglycerides as markers of angiographically assessed coronary artery disease.

M Nikkilä 1, T Koivula 1, K Niemelä 1, T Sisto 1
PMCID: PMC1024330  PMID: 2317412

Abstract

Serum triglycerides, high density lipoprotein (HDL) cholesterol, and total cholesterol were measured in 698 patients examined by angiography. The ratio of HDL cholesterol to total cholesterol was significantly lower in patients with single, double, and triple vessel disease than in patients without disease. The serum concentration of triglyceride was significantly higher in patients with single, double, and triple vessel disease than in those without coronary artery disease. Similar proportion of patients with coronary artery disease and without had serum cholesterol concentrations of greater than or equal to 6.5 mmol/l, but total cholesterol was significantly higher in patients with single, double, and triple vessel disease than in those without. HDL cholesterol (less than 1.0 mmol/l), triglycerides (greater than 2.0 mmol/l), and the ratio of HDL cholesterol to total cholesterol (less than 0.20) were significantly better than total cholesterol as indicators of coronary risk.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALBRINK M. J., MAN E. B. Serum triglycerides in coronary artery disease. AMA Arch Intern Med. 1959 Jan;103(1):4–8. doi: 10.1001/archinte.1959.00270010010002. [DOI] [PubMed] [Google Scholar]
  2. Aberg H., Lithell H., Selinus I., Hedstrand H. Serum triglycerides are a risk factor for myocardial infarction but not for angina pectoris. Results from a 10-year follow-up of Uppsala primary preventive study. Atherosclerosis. 1985 Jan;54(1):89–97. doi: 10.1016/0021-9150(85)90156-x. [DOI] [PubMed] [Google Scholar]
  3. Barbir M., Wile D., Trayner I., Aber V. R., Thompson G. R. High prevalence of hypertriglyceridaemia and apolipoprotein abnormalities in coronary artery disease. Br Heart J. 1988 Nov;60(5):397–403. doi: 10.1136/hrt.60.5.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown D. F., Kinch S. H., Doyle J. T. Serum triglycerides in health and in ischemic heart disease. N Engl J Med. 1965 Oct 28;273(18):947–952. doi: 10.1056/NEJM196510282731802. [DOI] [PubMed] [Google Scholar]
  5. Brunner D., Altman S., Loebl K., Schwartz S., Levin S. Serum cholesterol and triglycerides in patients suffering from ischemic heart disease and in healthy subjects. Atherosclerosis. 1977 Oct;28(2):197–204. doi: 10.1016/0021-9150(77)90157-5. [DOI] [PubMed] [Google Scholar]
  6. Brunner D., Weisbort J., Meshulam N., Schwartz S., Gross J., Saltz-Rennert H., Altman S., Loebl K. Relation of serum total cholesterol and high-density lipoprotein cholesterol percentage to the incidence of definite coronary events: twenty-year follow-up of the Donolo-Tel Aviv Prospective Coronary Artery Disease Study. Am J Cardiol. 1987 Jun 1;59(15):1271–1276. doi: 10.1016/0002-9149(87)90903-9. [DOI] [PubMed] [Google Scholar]
  7. CARLSON L. A. Serum lipids in men with myocardial infarction. Acta Med Scand. 1960 Aug 31;167:399–413. doi: 10.1111/j.0954-6820.1960.tb03562.x. [DOI] [PubMed] [Google Scholar]
  8. Carlson L. A., Böttiger L. E. Risk factors for ischaemic heart disease in men and women. Results of the 19-year follow-up of the Stockholm Prospective Study. Acta Med Scand. 1985;218(2):207–211. doi: 10.1111/j.0954-6820.1985.tb08848.x. [DOI] [PubMed] [Google Scholar]
  9. Carlson L. A., Rosenhamer G. Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid. Acta Med Scand. 1988;223(5):405–418. doi: 10.1111/j.0954-6820.1988.tb15891.x. [DOI] [PubMed] [Google Scholar]
  10. Castelli W. P. The triglyceride issue: a view from Framingham. Am Heart J. 1986 Aug;112(2):432–437. doi: 10.1016/0002-8703(86)90296-6. [DOI] [PubMed] [Google Scholar]
  11. Frick M. H., Elo O., Haapa K., Heinonen O. P., Heinsalmi P., Helo P., Huttunen J. K., Kaitaniemi P., Koskinen P., Manninen V. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med. 1987 Nov 12;317(20):1237–1245. doi: 10.1056/NEJM198711123172001. [DOI] [PubMed] [Google Scholar]
  12. Hamsten A., Wiman B., de Faire U., Blombäck M. Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction. N Engl J Med. 1985 Dec 19;313(25):1557–1563. doi: 10.1056/NEJM198512193132501. [DOI] [PubMed] [Google Scholar]
  13. Hamsten A., de Faire U., Walldius G., Dahlén G., Szamosi A., Landou C., Blombäck M., Wiman B. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction. Lancet. 1987 Jul 4;2(8549):3–9. doi: 10.1016/s0140-6736(87)93050-9. [DOI] [PubMed] [Google Scholar]
  14. Lapidus L., Bengtsson C., Lindquist O., Sigurdsson J. A., Rybo E. Triglycerides--main lipid risk factor for cardiovascular disease in women? Acta Med Scand. 1985;217(5):481–489. doi: 10.1111/j.0954-6820.1985.tb03251.x. [DOI] [PubMed] [Google Scholar]
  15. Manninen V., Elo M. O., Frick M. H., Haapa K., Heinonen O. P., Heinsalmi P., Helo P., Huttunen J. K., Kaitaniemi P., Koskinen P. Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study. JAMA. 1988 Aug 5;260(5):641–651. [PubMed] [Google Scholar]
  16. Martin M. J., Hulley S. B., Browner W. S., Kuller L. H., Wentworth D. Serum cholesterol, blood pressure, and mortality: implications from a cohort of 361,662 men. Lancet. 1986 Oct 25;2(8513):933–936. doi: 10.1016/s0140-6736(86)90597-0. [DOI] [PubMed] [Google Scholar]
  17. Miller N. E., Thelle D. S., Forde O. H., Mjos O. D. The Tromsø heart-study. High-density lipoprotein and coronary heart-disease: a prospective case-control study. Lancet. 1977 May 7;1(8019):965–968. doi: 10.1016/s0140-6736(77)92274-7. [DOI] [PubMed] [Google Scholar]
  18. Nikkilä E. A., Taskinen M. R., Sane T. Plasma high-density lipoprotein concentration and subfraction distribution in relation to triglyceride metabolism. Am Heart J. 1987 Feb;113(2 Pt 2):543–548. doi: 10.1016/0002-8703(87)90629-6. [DOI] [PubMed] [Google Scholar]
  19. Ross R. The pathogenesis of atherosclerosis--an update. N Engl J Med. 1986 Feb 20;314(8):488–500. doi: 10.1056/NEJM198602203140806. [DOI] [PubMed] [Google Scholar]
  20. Wilhelmsen L., Wedel H., Tibblin G. Multivariate analysis of risk factors for coronary heart disease. Circulation. 1973 Nov;48(5):950–958. doi: 10.1161/01.cir.48.5.950. [DOI] [PubMed] [Google Scholar]
  21. Zampogna A., Luria M. H., Manubens S. J., Luria M. A. Relationship between lipids and occlusive coronary artery disease. Arch Intern Med. 1980 Aug;140(8):1067–1069. [PubMed] [Google Scholar]

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