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. 2023 Jun 7;14:3308. doi: 10.1038/s41467-023-38865-z

Migratory allylic arylation of 1,n-enols enabled by nickel catalysis

Dan Zhao 1,#, Bing Xu 1,2,#, Can Zhu 1,✉
PMCID: PMC10247813  PMID: 37286547

Abstract

Transition-metal-catalyzed allylic substitution reactions (Tsuji−Trost reactions) proceeding via a π-allyl metal intermediate have been demonstrated as a powerful tool in synthetic chemistry. Herein, we disclose an unprecedented π-allyl metal species migration, walking on the carbon chain involving 1,4-hydride shift as confirmed by deuterium labeling experiments. This migratory allylic arylation can be realized under dual catalysis of nickel and lanthanide triflate, a Lewis acid. Olefin migration has been observed to preferentially occur with the substrate of 1,n-enols (n ≥ 3). The robust nature of the allylic substitution strategy is reflected by a broad scope of substrates with the control of regio- and stereoselectivity. DFT studies suggest that π-allyl metal species migration consists of the sequential β-H elimination and migratory insertion, with diene not being allowed to release from the metal center before producing a new π-allyl nickel species.

Subject terms: Homogeneous catalysis, Synthetic chemistry methodology, Catalytic mechanisms, Reaction mechanisms

Allylic substitution reactions have emerged as a powerful tool for the construction of C − C/X bonds. Here, the authors develop a migratory strategy of allylic arylation under the catalysis of nickel and lanthanide triflate.

Introduction

Transition-metal-catalyzed allylic substitution reactions (Tsuji−Trost reactions) have emerged as a powerful tool for the construction of carbon−carbon and carbon−heteroatom bonds with a broad scope of both electrophiles and nucleophiles (Fig. 1a)1. By employing an appropriate ligand, the utilization of a transition metal catalyst, including Pd2–5, Ir6,7, Rh8–14, Ru15–20, Co21–23, Cu24–32, Mo33–41, W42, and Ni43–60 realizes the control of regio- and stereoselectivity during nucleophilic substitution of the key π-allyl metal intermediate (Int-A), thus to deliver regio- and/or stereomerically pure organic compounds. On the other hand, migratory coupling reactions, combining bond migration with a coupling process, display unique regioselectivity controls, e.g., multiple 1,2-hydride shifts result in the walking of carbon−metal bond over long distances via olefin-metal intermediate (olefin-[M]-Int), leading to remote selectivity in coupling reactions (Fig. 1b)61–70. Recently, the groups of Kawatsura54 and Stanley57 independently reported nickel-catalyzed arylative substitution of homoallylic carbonates and alcohols respectively, and 1,3-hydride shift was involved during olefin migrations. In contrast, migratory allylic substitution, in which the walking of π-allyl metal species proceeds over the carbon chain via multiple 1,4-hydride shifts, are still unexplored (Fig. 1c). During one migration cycle, sequential β-H elimination and migratory insertion occurs with diene-metal complex (diene-[M]-Int) as the key intermediate71,72.

Fig. 1. Migratory Allylic Substitution Reactions.

Fig. 1

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a Classic allylic substitution reactions. b Migratory coupling reaction via olefin intermediate (well developed). c Migratory allylic substitution reaction via π-allyl metal migration (unexplored). d This work.

Herein, we disclose our recent observations on the migratory dehydroxylative allylic arylation under the catalysis of nickel and lanthanide triflate, a Lewis acid (Fig. 1d).

Results and discussion

Optimization of the reaction conditions

Preliminary attempt began with the substitution reaction of allylic alcohol 1a with PhB(OH)2 (2a) under the catalysis of Ni(cod)2. To our surprise, when electron-rich ligand PCy3 was employed, the reaction does not undergo a direct allylic phenylation pathway to access 3-A or 3-B73. Instead, migratory phenylation product 3 was unexpectedly obtained in 30% yield (Table 1, entry 1), meanwhile the formation of ketone 4 was also detected, generated from 1a via intramolecular transfer hydrogenation. Obviously, migration of allylic species occurs preferentially, and product 3 was consequently produced via coupling reaction with PhB(OH)2 as the last step. Interestingly, base does not favor the Suzuki coupling reaction towards 3 (Table 1, entry 2). Therefore, a series of Lewis acids were investigated as additive to the reaction respectively (Table 1, entries 3–9). To our delight, La(OTf)3 gave the best performance, and the yield was dramatically improved to 68%, with side product 4 less than 5% (Table 1, entry 9). Further ligand screening fails to give better results (Table 1, entries 10–14). It is noteworthy to mention that bidentate ligands completely prevent the formation of 3. The yield of migratory arylation was improved to 75% in the solvent of methyl tert-butyl ether (MTBE) (Table 1, entries 15–19). Increasing the temperature to 110 °C does not give further promotion (Table 1, entry 20). Finally, Ni(cod)2 (10 mol%), PCy3 (20 mol%), La(OTf)3 (20 mol%), and PhB(OH)2 (2.0 equiv) in MTBE at 90 °C for 12 h were defined as the optimal reaction conditions for additional studies.

Table 1.

Migratory dehydroxylative allylic arylation of 1,2-Enols: condition optimizationa

graphic file with name 41467_2023_38865_Taba_HTML.gif
Entry Solvent Ligand additive Yield of 3 (%)b Yield of 4 (%)b Recovery of 1a (%)b
1 toluene PCy3 — 30 <5 n.d.
2 toluene PCy3 K2CO3 19 <5 28
3 toluene PCy3 FeCl3 n.d. 8 36
4 toluene PCy3 Fe(OTf)2 60 7 n.d.
5 toluene PCy3 Zn(OTf)2 36 <5 n.d.
6 toluene PCy3 Mn(OTf)2 54 <5 n.d.
7 toluene PCy3 In(OTf)3 21 6 n.d.
8 toluene PCy3 Sc(OTf)3 25 <5 n.d.
9 toluene PCy3 La(OTf)3 68 <5 n.d.
10 toluene PtBu3 La(OTf)3 11 <5 10
11 toluene PPh3 La(OTf)3 n.d. 43 n.d.
12c toluene BINAP La(OTf)3 n.d. 20 n.d.
13c toluene bpy La(OTf)3 n.d. n.d. 52
14c toluene Phen La(OTf)3 n.d. n.d. n.d.
15 dioxane PCy3 La(OTf)3 52 7 n.d.
16 DCE PCy3 La(OTf)3 13 <5 12
17 THF PCy3 La(OTf)3 27 6 26
18 n-hexane PCy3 La(OTf)3 55 <5 n.d.
19 MTBE PCy3 La(OTf)3 75(72) <5 n.d.
20d MTBE PCy3 La(OTf)3 75 <5 n.d.
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aThe reaction was carried out with PhB(OH)2 (2.0 equiv.), Ni(cod)2 (10 mol%), Ligand (20 mol%), and 1a (0.2 M) in indicated solvent (1.0 mL) at 90 °C for 12 h. bDetermined by 1H NMR analysis using dibromomethane as the internal standard, and value in parentheses is the isolated yield. c10 mol% of bidentate ligand was used. dThe reaction was conducted at 110 °C. n.d. not detected, DCE 1,2-dichloroethane, THF tetrahydrofuran, MTBE methyl tert-butyl ether, bpy: 2,2′-bipyridine, Phen 1,10-phenanthroline.

Scope of the reaction

With the optimized conditions in hand, we started to investigate the scope of this coupling reaction under dual catalysis (Fig. 2). Arylboronic acids irrespectively bearing electron donating groups or electron withdrawing groups all reacted with good yields (3, and 5−10). To our delight, a variety of functional groups, including 2-Me, 2-OMe, 2-F, 3-Me, 3-OMe, 3-F, 3-CF3, 4-Me, 4-tBu, 4-Ph, 4-OMe, 4-F, 4-Cl, 4-CF3, and 4-OCF3 on the benzene ring turned out to be compatible under the standard reaction conditions (11−25). Notably, medicinally prevalent aromatic moieties other than benzene were incorporated smoothly, including 1-naphthyl, 2-naphthyl, 3-indolyl, 2-thiophenyl, and 3-thiophenyl groups (26−30). 1,2-Enol featuring a terminal olefin works as well, affording arylated product 31 in 63% yield correspondingly. Scope of 1,2-enols could also be extended to those bearing long aliphatic chains (32−35). However, migratory phenylation fails to construct a quaternary carbon center in 36. Moreover, 1,2-enol featuring a tertiary alcohol led to tri-substituted alkene via migratory arylation process. The reactions of cyclic 1,2-enols work nicely to afford indene derivative 37, bearing a fused five-membered ring, as well as product owning a fused six- (38) or seven-membered ring (39), and such units have been widely found in various natural products and drug molecules. Finally, it is noteworthy to mention that all the reactions give regio- and stereospecific products via migratory allylic substitutions, exhibiting the synthetic robustness of this dual catalytic protocol.

Fig. 2. Substrate Scope.

Fig. 2

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The reaction was carried out with enaol 1 (0.2 M), ArB(OH)2 (2.0 equiv.), Ni(cod)2 (10 mol%), PCy3 (20 mol%), and La(OTf)3 (20 mol%) in MTBE (1.0 mL) at 90 oC for 12 h.

To learn more about reactivity of the migratory allylic arylation transformation, comparison experiments were carried out under the standard conditions by employing (E)-enol and its stereoisomer (Z)-enol parallelly. The reaction of (E)−1a afforded migratory phenylated product 3 in 72% yield, and almost the same yield (73%) of 3 could be produced starting from its stereoisomer, (Z )−1a (Fig. 3a). Similar results could be obtained with tertiary enol (E)-1b or (Z )-1b as substrates, yielding 59% and 58% of the same product 37 respectively. These outcomes suggest the reaction proceeding via the same intermediate from both stereoisomers, implying the intermediacy of π-allyl metal species. Next, the scope of enols was investigated with OH group and/or olefin moiety at a different position on the carbon chain (Fig. 3b). 1,3-Enol 1c, with a terminal olefin could also be employed to yield 3 in 71%, the same product as the reaction of 1a. 1,4-enol 1d, with olefin distancing one more carbon from OH group gave a decreased yield of 38%. Direct allylic arylation occurs efficiently with allylic alcohol 1e. The reaction of allylic alcohol 1 f, in which two more carbons locate between phenyl and OH group compared with 1e, resulting in the corresponding phenylated product in a decreased yield of 42%, implying consecutive π-allyl metal species migrations before the final coupling with PhB(OH)2. Further studies were carried out by employing 1,n-enols 1g-m (n = 3–10), featuring different distances of olefin unit from OH group. To our delight, these enols are all compatible in the migratory arylation transformations, leading to the migration products in 25–85% yields. These observations make clear that olefin migration preferentially occurs to generate the corresponding allylic alcohol, which further undergoes a substitution reaction with ArB(OH)2 under nickel catalysis. It is worth noting that, in these types of reactions, the preferential olefin migration undergoes via multiple 1,2-hydride shift, and 1,3-hydride shift was also possibly involved in the reaction of 1,3-enols (e.g., 1 g)54. Given the fact that mixtures of olefin or alcohol isomers are abundant industrial feedstocks, and are more easily accessible with less expense than pure isomers, the direct employment of isomers in regio- and stereoconvergent reactions to produce value-added products is of considerable interest. As shown in Fig. 3c, the reaction using a mixture of six regio- and stereoisomers (1:1:1:1:1:1) delivers regio- and stereodefined product 3 in 64% yield. Next, when an alkenylboronic acid was employed in the reaction of (E)−1a, we are glad to obtain the corresponding alkenylated product 3-alkenyl in 24% yield (Fig. 3d). However, cyclopentylboronic acid fails to promote the alkylation reaction of (E)−1a. Finally, asymmetric migratory allylic arylation of enols 1o and 1 h was investigated, and preliminary attempts were conducted to achieve good enantioselective controls with chiral bidentate nitrogen ligands L1 and L2 respectively (91:9 er for 31, 82:18 er for 3), but with low yields in both reactions (for details see page S57-60 in the supplementary discussion section of Supplementary Information).

Fig. 3. Regio- and stereoconvergent transformations.

Fig. 3

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a Reactivity comparison of (E)- and (Z)-enols. b Reaction of enols with OH group and/or olefin moiety at different positions. c Reaction of a mixture of six regio- and stereoisomers. d Reaction of (E)-1a with an alkenyl or alkyl boronic acid.

Mechanistic studies

To gain a deeper insight of the mechanism of this migratory arylation reaction, control experiments with enol 1n were performed. When the reaction was stopped in 1 h, corresponding product 21 was formed in 18% yield, while diene 40 was not detected via dehydration from 1n (Fig. 4a). Further reaction of diene 40 directly under the standard reaction conditions also failed to yield product 21. When diene 40 was introduced as an additive in the reaction of 1a, migratory arylation product 3 was generated from 1a in 70% yield, while 21 was not detected from diene additive 40. These observations point out that migratory arylation transformations are not proceeding via simple dehydration of enols, and diene cannot access the final products via hydroarylation, indicating that the intermediacy of diene could be ruled out. Moreover, deuterium labeling experiments were carried out to investigate the reaction details during migration (Fig. 4b). When deuterated d2−1a was employed under the standard conditions, 95% deuterium incorporation was observed at 4-position, making clear that a specific 1,4-hydride shift occurs during the migratory process. Finally, no intermolecular H/D exchange was observed from the deuterium cross-over reaction of d2−1a and 1e in a one-pot manner (Fig. 4c), implying the prior formation of the new π-allyl nickel intermediate from diene-Ni-Int before the possible disassociation of diene-ligand from the metal, which differs from many cases involving chain-walking process via olefins57.

Fig. 4. Mechanistic studies.

Fig. 4

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a Control experiments. b Deuterium labeling experiments. c Intermolecular cross-over reaction.

To account for the 1,4-hydride shift process observed by the aforementioned deuterium labeling experiments, density functional theory (DFT) calculations were carried out using 1a as model substrate along with the Ni(0)−PCy3 catalytic system (for details of the optimized structures see coordination data sets and free energies in Supplementary Data 1). The free energy profiles of the preferred 1,4-hydride transfer pathways for (Z)-1a and (E)-1a represented by the black line and the blue line, respectively, are shown in Fig. 5, taking the π-allyl nickel species Int1b as the free energy reference. In the case of (E)-1a, isomerization of π-allyl nickel species Int1b affords Int2b, which undergoes β-hydride elimination via Ts1b with an energy barrier of 20.1 kcal.mol−1 (TS1b with respective to int1b) to form the diene-nickel complex Int3b. Hydrometallation of Int4b, generated by the further isomerization of Int3b, needs to overcome an activation barrier of only 5.1 kcal.mol−1 (Ts2b), providing a new and desired π-allyl nickel species Int5. A similar situation can be found in the case of (Z)-1a with slightly higher free energy demanding. These calculations indicate that both stereoisomers of 1a can undergo the 1,4-hydride transfer process to furnish the same π-allyl nickel complex Int5, which is in line with the experimental observation in Fig. 3. Moreover, the dissociation of the diene-nickel complex Int3a to form Int3a-p1 and Int3a-p2 indicated by red line was also considered, and the higher energy barrier rules out the possibility of the formation of diene, consistent with the results experimentally observed in Fig. 4.

Fig. 5. DFT studies.

Fig. 5

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Free-energy reaction profiles (kcal mol−1) are presented for the 1,4-hydride transfer process of two stereoisomers of 1a, calculated at the PBE0/combined basis set level at 363 K.

Based on the regiochemical outcome, mechanistic experiments in Fig. 4, and DFT calculation results in Fig. 5, a possible mechanism for the migratory allylic arylation reaction is proposed in Fig. 6. Ligand exchange of Ni(cod)2 with PCy3 generates the active catalyst Ni(PCy3)2, which undergoes the reaction with allylic alcohol 1a via oxidative addition to give π-allyl nickel species Int1. Olefin migration occurs to produce the corresponding allylic alcohols when 1,n-enols (n ≥ 3) are employed, e.g., 1,3-enol 1c. The hydroxyl group performs as a leaving group after being activated by La(OTf)3, a Lewis acid. β-Hydride elimination of Int1 affords diene-nickel complex Int3, which further transforms to a new π-allyl nickel species Int5 via hydrometallation. It is noteworthy to mention that the active NiH species in Int3 is believed to be generated via β-hydride elimination, instead of being formed via oxidative addition of alcohols in many other cases74–77. Transformation from one π-allyl species (Int1) to the other (Int5) proceeds via an overall 1,4-hydride shift, and disassociation of the diene-ligand in Int3 from the metal seems not possible as confirmed by the deuterium labeling and cross-over studies. Finally, transmetallation of Int5 with ArB(OH)2 produces Int6, which on subsequent reductive elimination leads to the final product 3, releasing the nickel(0) catalyst to close the cycle.

Fig. 6. Proposed mechanism.

Fig. 6

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A plausible reaction pathway for migratory dehydroxylative allylic arylation of 1,n-enols.

To sum up, we have developed a migratory dehydroxylative allylic arylation of unactivated 1,n-enols enabled by dual nickel/Lewis acid catalysis with high regio- and stereoselectivity. The reaction proceeds via unprecedented π-allyl nickel species migration involving 1,4-hydride shift as confirmed by deuterium labeling experiments. DFT studies suggest that π-allyl metal species migration consists of the sequential β-H elimination and migratory insertion, with diene not being allowed to release from the metal center before hydrometallation to produce a new π-allyl nickel species. Olefin migration was observed to preferentially occur starting from 1,n-enols (n ≥ 3). The method provides a facile and migratory strategy to construct C(sp2)–C(sp3) bonds with unique selectivity and features a broad substrate scope for both arylboronic acids and 1,n-enols. Further studies on the mechanism, synthetic application, and asymmetric variants are currently ongoing in our laboratory.

Methods

Representative procedure for migratory allylic arylation of 1,n-enols enabled by nickel catalysis

Under a nitrogen atmosphere, a mixture of Ni(cod)2 (5.5 mg, 0.02 mmol), PCy3 (11.2 mg, 0.04 mmol), Lewis acid (0.04 mmol), and ArB(OH)2 (0.4 mmol) was added a solution of corresponding enol (0.2 mmol) in MTBE (1.0 mL). The reaction was sealed and stirred at 90 °C or 100 °C for 12 h. Subsequently, the reaction was cooled down to room temperature and the mixture was evaporated and purified via column chromatography on silica gel (eluent: petroleum ether/ethyl acetate) afforded the desired product.

Supplementary information

Supplementary Information (10MB, pdf)
Peer Review File (4MB, pdf)
41467_2023_38865_MOESM3_ESM.pdf (71.2KB, pdf)

Description of Additional Supplementary Files

Supplementary Data 1 (181.9KB, pdf)

Acknowledgements

We acknowledge the National Natural Science Foundation of China (Grant No. 22271054, C.Z.), the China Postdoctoral Science Foundation (2022M713667, B.X.), the “1000-Youth Talents Plan”, and Fudan University (start-up grant) for financial support. We also thank Mr. Jun Zhang for his help in revisions, Prof. Huadong Wang and Bing-Tao Guan for insightful and fruitful discussions. This research paper is dedicated to Prof. Li-Xin Dai on the occasion of his 100th birthday.

Author contributions

C.Z. conceived the project, analyzed the data, and wrote the manuscript. D.Z. performed the most of experiments. B.X. did the DFT calculations. All authors discussed the results and commented on the manuscript.

Peer review

Peer review information

Nature Communications thanks the anonymous reviewers for their contribution to the peer review of this work. A peer review file is available.

Data availability

All data generated or analyzed during this study are included in this Article and the Supplementary Information. Details about materials and methods, experimental procedures, mechanistic studies, characterization data, computational details, NMR and HPLC spectra are available in the Supplementary Information. Calculated coordinates are available in the Supplementary Data file. All other data are available from the corresponding author upon request.

Competing interests

The authors declare no competing interests.

Footnotes

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

These authors contributed equally: Dan Zhao, Bing Xu.

Supplementary information

The online version contains supplementary material available at 10.1038/s41467-023-38865-z.

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Supplementary Materials

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Data Availability Statement

All data generated or analyzed during this study are included in this Article and the Supplementary Information. Details about materials and methods, experimental procedures, mechanistic studies, characterization data, computational details, NMR and HPLC spectra are available in the Supplementary Information. Calculated coordinates are available in the Supplementary Data file. All other data are available from the corresponding author upon request.

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