Abstract
Objectives—To study the differences between endocardial bipolar and unipolar ventricular paced evoked responses and surface electrocardiograms.
Patients—10 patients with conduction system disease awaiting insertion of a permanent pacemaker were studied with temporary ventricular pacing from the right ventricular apex.
Main outcome measure—Comparison of the durations of the QRS complexes and QTa and QTe intervals of the endocardial bipolar paced evoked response and the surface electrocardiogram with those of the reference unipolar paced evoked response.
Results—By comparison with the unipolar reference, the mean durations of the QRS complexes of the bipolar signal and the surface electrocardiogram were 41·8% and 132·1% respectively. The mean QTa interval was 85·9% and 112·2% respectively and the mean QTe interval was 86·9% and 109·5% respectively. All these differences were significant. The amplitudes of the unipolar QRS complexes and T waves were significantly larger than those recorded in the bipolar configuration.
Conclusions—Differences between the unipolar and bipolar ventricular paced evoked responses are significant. The time course of the unipolar signal is closer to that of the surface electrocardiogram. This indicates that the unipolar paced evoked response does not reflect local electrophysiological events, as has been suggested previously.
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arnold L., Page J., Attwell D., Cannell M., Eisner D. A. The dependence on heart rate of the human ventricular action potential duration. Cardiovasc Res. 1982 Oct;16(10):547–551. doi: 10.1093/cvr/16.10.547. [DOI] [PubMed] [Google Scholar]
- Autenrieth G., Surawicz B., Kuo C. S., Arita M. Primary T wave abnormalities caused by uniform and regional shortening of ventricular monophasic action potential in dog. Circulation. 1975 Apr;51(4):668–676. doi: 10.1161/01.cir.51.4.668. [DOI] [PubMed] [Google Scholar]
- Blanchard S. M., Damiano R. J., Jr, Asano T., Smith W. M., Ideker R. E., Lowe J. E. The effects of distant cardiac electrical events on local activation in unipolar epicardial electrograms. IEEE Trans Biomed Eng. 1987 Jul;34(7):539–546. doi: 10.1109/tbme.1987.325983. [DOI] [PubMed] [Google Scholar]
- Blanchard S. M., Damiano R. J., Jr, Smith W. M., Ideker R. E., Lowe J. E. Interpolating unipolar epicardial potentials from electrodes separated by increasing distances. Pacing Clin Electrophysiol. 1989 Dec;12(12):1938–1955. doi: 10.1111/j.1540-8159.1989.tb01887.x. [DOI] [PubMed] [Google Scholar]
- Boyett M. R., Jewell B. R. A study of the factors responsible for rate-dependent shortening of the action potential in mammalian ventricular muscle. J Physiol. 1978 Dec;285:359–380. doi: 10.1113/jphysiol.1978.sp012576. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Castellanos A., Jr, Ortiz J. M., Pastis N., Castillo C. The electrocardiogram in patients with pacemakers. Prog Cardiovasc Dis. 1970 Sep;13(2):190–209. doi: 10.1016/0033-0620(70)90008-3. [DOI] [PubMed] [Google Scholar]
- Corbin L. V., 2nd, Scher A. M. The canine heart as an electrocardiographic generator. Dependence on cardiac cell orientation. Circ Res. 1977 Jul;41(1):58–67. doi: 10.1161/01.res.41.1.58. [DOI] [PubMed] [Google Scholar]
- DOWER G. E., GEDDES M. A. True transmembrane potential curve from the surface of guinea pig ventricle: its relation to intrinsic deflection. Am J Physiol. 1960 May;198:975–980. doi: 10.1152/ajplegacy.1960.198.5.975. [DOI] [PubMed] [Google Scholar]
- DeCaprio V., Hurzeler P., Furman S. A comparison of unipolar and bipolar electrograms for cardiac pacemaker sensing. Circulation. 1977 Nov;56(5):750–755. doi: 10.1161/01.cir.56.5.750. [DOI] [PubMed] [Google Scholar]
- Donaldson R. M., Rickards A. F. Evaluation of drug-induced changes in myocardial repolarisation using the paced evoked response. Br Heart J. 1982 Oct;48(4):381–387. doi: 10.1136/hrt.48.4.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Donaldson R. M., Rickards A. F. The ventricular endocardial paced evoked response. Pacing Clin Electrophysiol. 1983 Mar;6(2 Pt 1):253–259. doi: 10.1111/j.1540-8159.1983.tb04354.x. [DOI] [PubMed] [Google Scholar]
- Donaldson R. M., Taggart P., Nashat F., Abed J., Rickards A. F., Noble D. Study of the electrophysiological effects of early or subendocardial ischaemia with intracavitary electrodes in the dog. Clin Sci (Lond) 1983 Dec;65(6):579–588. doi: 10.1042/cs0650579. [DOI] [PubMed] [Google Scholar]
- Furman S., Hurzeler P., De Caprio V. Cardiac pacing and pacemaker. III. Sensing the cardiac electrogram. Am Heart J. 1977 Jun;93(6):794–801. doi: 10.1016/s0002-8703(77)80078-1. [DOI] [PubMed] [Google Scholar]
- GESELOWITZ D. B. DIPOLE THEORY IN ELECTROCARDIOGRAPHY. Am J Cardiol. 1964 Sep;14:301–306. doi: 10.1016/0002-9149(64)90072-4. [DOI] [PubMed] [Google Scholar]
- Gordon A. J., Vagueiro M. C., Barold S. S. Endocardial electrograms from pacemaker catheters. Circulation. 1968 Jul;38(1):82–89. doi: 10.1161/01.cir.38.1.82. [DOI] [PubMed] [Google Scholar]
- HUDNUT H. B., Jr, KEY C., JAQUES W. E. Embolism to the right side of the heart. Am Heart J. 1962 Jun;63:743–746. doi: 10.1016/0002-8703(62)90058-3. [DOI] [PubMed] [Google Scholar]
- Harumi K., Burgess M. J., Abildskov J. A. A theoretic model of the T wave. Circulation. 1966 Oct;34(4):657–668. doi: 10.1161/01.cir.34.4.657. [DOI] [PubMed] [Google Scholar]
- Holland R. P., Arnsdorf M. F. Solid angle theory and the electrocardiogram: physiologic and quantitative interpretations. Prog Cardiovasc Dis. 1977 May-Jun;19(6):431–457. doi: 10.1016/0033-0620(77)90009-3. [DOI] [PubMed] [Google Scholar]
- LEPESCHKIN E., SURAWICZ B. The measurement of the Q-T interval of the electrocardiogram. Circulation. 1952 Sep;6(3):378–388. doi: 10.1161/01.cir.6.3.378. [DOI] [PubMed] [Google Scholar]
- Mansfield P. B. Myocardial stimulation: the electrochemistry of electrode-tissue coupling. Am J Physiol. 1967 Jun;212(6):1475–1488. doi: 10.1152/ajplegacy.1967.212.6.1475. [DOI] [PubMed] [Google Scholar]
- Rickards A. F., Norman J. Relation between QT interval and heart rate. New design of physiologically adaptive cardiac pacemaker. Br Heart J. 1981 Jan;45(1):56–61. doi: 10.1136/hrt.45.1.56. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHER A. M., YOUNG A. C. Ventricular depolarization and the genesis of QRS. Ann N Y Acad Sci. 1957 Aug 9;65(6):768–778. doi: 10.1111/j.1749-6632.1957.tb36682.x. [DOI] [PubMed] [Google Scholar]
- Selvester R. H., Solomon J. C., Gillespie T. L. Digital computer model of a total body electrocardiographic surface map. An adult male-torso simulation with lungs. Circulation. 1968 Oct;38(4):684–690. doi: 10.1161/01.cir.38.4.684. [DOI] [PubMed] [Google Scholar]
- Spach M. S., Barr R. C. Ventricular intramural and epicardial potential distributions during ventricular activation and repolarization in the intact dog. Circ Res. 1975 Aug;37(2):243–257. doi: 10.1161/01.res.37.2.243. [DOI] [PubMed] [Google Scholar]
- Steinhaus B. M. Estimating cardiac transmembrane activation and recovery times from unipolar and bipolar extracellular electrograms: a simulation study. Circ Res. 1989 Mar;64(3):449–462. doi: 10.1161/01.res.64.3.449. [DOI] [PubMed] [Google Scholar]
- VAN DAMR, DURRER D. THE T WAVE AND VENTRICULAR REPOLARIZATION. Am J Cardiol. 1964 Sep;14:294–300. doi: 10.1016/0002-9149(64)90071-2. [DOI] [PubMed] [Google Scholar]