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British Heart Journal logoLink to British Heart Journal
. 1993 Jun;69(6):473–475. doi: 10.1136/hrt.69.6.473

Insulin and atherosclerosis: villain, accomplice, or innocent bystander?

P J Savage, M F Saad
PMCID: PMC1025152  PMID: 8343309

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Selected References

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  1. Abbott W. G., Lillioja S., Young A. A., Zawadzki J. K., Yki-Järvinen H., Christin L., Howard B. V. Relationships between plasma lipoprotein concentrations and insulin action in an obese hyperinsulinemic population. Diabetes. 1987 Aug;36(8):897–904. doi: 10.2337/diab.36.8.897. [DOI] [PubMed] [Google Scholar]
  2. Brindley D. N., Rolland Y. Possible connections between stress, diabetes, obesity, hypertension and altered lipoprotein metabolism that may result in atherosclerosis. Clin Sci (Lond) 1989 Nov;77(5):453–461. doi: 10.1042/cs0770453. [DOI] [PubMed] [Google Scholar]
  3. Canner P. L., Berge K. G., Wenger N. K., Stamler J., Friedman L., Prineas R. J., Friedewald W. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol. 1986 Dec;8(6):1245–1255. doi: 10.1016/s0735-1097(86)80293-5. [DOI] [PubMed] [Google Scholar]
  4. Cigolini M., Seidell J. C., Charzewska J., Ellsinger B. M., DiBiase G., Björntorp P., Hautvast J. G., Contaldo F., Szostak V., Scuro L. A. Fasting serum insulin in relation to fat distribution, serum lipid profile, and blood pressure in European women: the European Fat Distribution Study. Metabolism. 1991 Aug;40(8):781–787. doi: 10.1016/0026-0495(91)90003-f. [DOI] [PubMed] [Google Scholar]
  5. Collins V. R., Dowse G. K., Finch C. F., Zimmet P. Z. An inconsistent relationship between insulin and blood pressure in three Pacific island populations. J Clin Epidemiol. 1990;43(12):1369–1378. doi: 10.1016/0895-4356(90)90104-w. [DOI] [PubMed] [Google Scholar]
  6. Cruickshank J. K., Cooper J., Burnett M., MacDuff J., Drubra U. Ethnic differences in fasting plasma C-peptide and insulin in relation to glucose tolerance and blood pressure. Lancet. 1991 Oct 5;338(8771):842–847. doi: 10.1016/0140-6736(91)91501-k. [DOI] [PubMed] [Google Scholar]
  7. Cullen K., Stenhouse N. S., Wearne K. L., Welborn T. A. Multiple regression analysis of risk factors for cardiovascular disease and cancer mortality in Busselton, Western Australia--13-year study. J Chronic Dis. 1983;36(5):371–377. doi: 10.1016/0021-9681(83)90169-8. [DOI] [PubMed] [Google Scholar]
  8. DeFronzo R. A., Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 1991 Mar;14(3):173–194. doi: 10.2337/diacare.14.3.173. [DOI] [PubMed] [Google Scholar]
  9. Ducimetiere P., Eschwege E., Papoz L., Richard J. L., Claude J. R., Rosselin G. Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population. Diabetologia. 1980 Sep;19(3):205–210. doi: 10.1007/BF00275270. [DOI] [PubMed] [Google Scholar]
  10. Durrington P. N. Is insulin atherogenic? Diabet Med. 1992 Aug-Sep;9(7):597–600. doi: 10.1111/j.1464-5491.1992.tb01852.x. [DOI] [PubMed] [Google Scholar]
  11. Eriksson K. F., Lindgärde F. Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. The 6-year Malmö feasibility study. Diabetologia. 1991 Dec;34(12):891–898. doi: 10.1007/BF00400196. [DOI] [PubMed] [Google Scholar]
  12. Ferrannini E., Buzzigoli G., Bonadonna R., Giorico M. A., Oleggini M., Graziadei L., Pedrinelli R., Brandi L., Bevilacqua S. Insulin resistance in essential hypertension. N Engl J Med. 1987 Aug 6;317(6):350–357. doi: 10.1056/NEJM198708063170605. [DOI] [PubMed] [Google Scholar]
  13. Frayn K. N., Coppack S. W. Insulin resistance, adipose tissue and coronary heart disease. Clin Sci (Lond) 1992 Jan;82(1):1–8. doi: 10.1042/cs0820001. [DOI] [PubMed] [Google Scholar]
  14. Haffner S. M., Fong D., Hazuda H. P., Pugh J. A., Patterson J. K. Hyperinsulinemia, upper body adiposity, and cardiovascular risk factors in non-diabetics. Metabolism. 1988 Apr;37(4):338–345. doi: 10.1016/0026-0495(88)90133-3. [DOI] [PubMed] [Google Scholar]
  15. Hargreaves A. D., Logan R. L., Elton R. A., Buchanan K. D., Oliver M. F., Riemersma R. A. Glucose tolerance, plasma insulin, HDL cholesterol and obesity: 12-year follow-up and development of coronary heart disease in Edinburgh men. Atherosclerosis. 1992 May;94(1):61–69. doi: 10.1016/0021-9150(92)90188-m. [DOI] [PubMed] [Google Scholar]
  16. Juhan-Vague I., Vague P. Hypofibrinolysis and insulin-resistance. Diabete Metab. 1991 May;17(1 Pt 2):96–100. [PubMed] [Google Scholar]
  17. Kahn S. E., Beard J. C., Schwartz M. W., Ward W. K., Ding H. L., Bergman R. N., Taborsky G. J., Jr, Porte D., Jr Increased beta-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance. Diabetes. 1989 May;38(5):562–568. doi: 10.2337/diab.38.5.562. [DOI] [PubMed] [Google Scholar]
  18. Karam J. H. Type II diabetes and syndrome X. Pathogenesis and glycemic management. Endocrinol Metab Clin North Am. 1992 Jun;21(2):329–350. [PubMed] [Google Scholar]
  19. Laakso M., Edelman S. V., Brechtel G., Baron A. D. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J Clin Invest. 1990 Jun;85(6):1844–1852. doi: 10.1172/JCI114644. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Liu Q. Z., Knowler W. C., Nelson R. G., Saad M. F., Charles M. A., Liebow I. M., Bennett P. H., Pettitt D. J. Insulin treatment, endogenous insulin concentration, and ECG abnormalities in diabetic Pima Indians. Cross-sectional and prospective analyses. Diabetes. 1992 Sep;41(9):1141–1150. doi: 10.2337/diab.41.9.1141. [DOI] [PubMed] [Google Scholar]
  21. Logan R. L., Riemersma R. A., Thomson M., Oliver M. F., Olsson A. G., Walldius G., Rössner S., Kaijser L., Callmer E., Carlson L. A. Risk factors for ischaemic heart-disease in normal men aged 40. Edinburgh-Stockholm Study. Lancet. 1978 May 6;1(8071):949–954. doi: 10.1016/s0140-6736(78)90246-5. [DOI] [PubMed] [Google Scholar]
  22. Manolio T. A., Savage P. J., Burke G. L., Liu K. A., Wagenknecht L. E., Sidney S., Jacobs D. R., Jr, Roseman J. M., Donahue R. P., Oberman A. Association of fasting insulin with blood pressure and lipids in young adults. The CARDIA study. Arteriosclerosis. 1990 May-Jun;10(3):430–436. doi: 10.1161/01.atv.10.3.430. [DOI] [PubMed] [Google Scholar]
  23. McKeigue P. M., Shah B., Marmot M. G. Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet. 1991 Feb 16;337(8738):382–386. doi: 10.1016/0140-6736(91)91164-p. [DOI] [PubMed] [Google Scholar]
  24. Modan M., Halkin H., Almog S., Lusky A., Eshkol A., Shefi M., Shitrit A., Fuchs Z. Hyperinsulinemia. A link between hypertension obesity and glucose intolerance. J Clin Invest. 1985 Mar;75(3):809–817. doi: 10.1172/JCI111776. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Modan M., Or J., Karasik A., Drory Y., Fuchs Z., Lusky A., Chetrit A., Halkin H. Hyperinsulinemia, sex, and risk of atherosclerotic cardiovascular disease. Circulation. 1991 Sep;84(3):1165–1175. doi: 10.1161/01.cir.84.3.1165. [DOI] [PubMed] [Google Scholar]
  26. Muller D. C., Elahi D., Pratley R. E., Tobin J. D., Andres R. An epidemiological test of the hyperinsulinemia-hypertension hypothesis. J Clin Endocrinol Metab. 1993 Mar;76(3):544–548. doi: 10.1210/jcem.76.3.8445009. [DOI] [PubMed] [Google Scholar]
  27. Pollare T., Lithell H., Berne C. Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metabolism. 1990 Feb;39(2):167–174. doi: 10.1016/0026-0495(90)90071-j. [DOI] [PubMed] [Google Scholar]
  28. Pyöräla K. Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland. Diabetes Care. 1979 Mar-Apr;2(2):131–141. doi: 10.2337/diacare.2.2.131. [DOI] [PubMed] [Google Scholar]
  29. Reaven G. M. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988 Dec;37(12):1595–1607. doi: 10.2337/diab.37.12.1595. [DOI] [PubMed] [Google Scholar]
  30. Saad M. F., Lillioja S., Nyomba B. L., Castillo C., Ferraro R., De Gregorio M., Ravussin E., Knowler W. C., Bennett P. H., Howard B. V. Racial differences in the relation between blood pressure and insulin resistance. N Engl J Med. 1991 Mar 14;324(11):733–739. doi: 10.1056/NEJM199103143241105. [DOI] [PubMed] [Google Scholar]
  31. Stout R. W. Insulin and atheroma. 20-yr perspective. Diabetes Care. 1990 Jun;13(6):631–654. doi: 10.2337/diacare.13.6.631. [DOI] [PubMed] [Google Scholar]
  32. Stout R. W., Vallance-Owen J. Insulin and atheroma. Lancet. 1969 May 31;1(7605):1078–1080. doi: 10.1016/s0140-6736(69)91711-5. [DOI] [PubMed] [Google Scholar]
  33. Suter S. L., Nolan J. J., Wallace P., Gumbiner B., Olefsky J. M. Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care. 1992 Feb;15(2):193–203. doi: 10.2337/diacare.15.2.193. [DOI] [PubMed] [Google Scholar]
  34. Welborn T. A., Wearne K. Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentrations. Diabetes Care. 1979 Mar-Apr;2(2):154–160. doi: 10.2337/diacare.2.2.154. [DOI] [PubMed] [Google Scholar]
  35. Welin L., Eriksson H., Larsson B., Ohlson L. O., Svärdsudd K., Tibblin G. Hyperinsulinaemia is not a major coronary risk factor in elderly men. The study of men born in 1913. Diabetologia. 1992 Aug;35(8):766–770. doi: 10.1007/BF00429098. [DOI] [PubMed] [Google Scholar]
  36. Widén E. I., Eriksson J. G., Groop L. C. Metformin normalizes nonoxidative glucose metabolism in insulin-resistant normoglycemic first-degree relatives of patients with NIDDM. Diabetes. 1992 Mar;41(3):354–358. doi: 10.2337/diab.41.3.354. [DOI] [PubMed] [Google Scholar]
  37. Zavaroni I., Bonora E., Pagliara M., Dall'Aglio E., Luchetti L., Buonanno G., Bonati P. A., Bergonzani M., Gnudi L., Passeri M. Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med. 1989 Mar 16;320(11):702–706. doi: 10.1056/NEJM198903163201105. [DOI] [PubMed] [Google Scholar]

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