Abstract
An 18 year old man presented with cough and dyspnoea caused by pulmonary infarction. A large friable mass of organising thrombus in an anatomically normal right ventricle was identified as an embolic source. The acute illness was associated with raised titres of anticardiolipin antibodies, one of the antiphospholipid group. This thrombus recurred after surgical removal but subsequently was dissipated after treatment with oral corticosteroids and long-term oral anticoagulation.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Asherson R. A., Chan J. K., Harris E. N., Gharavi A. E., Hughes G. R. Anticardiolipin antibody, recurrent thrombosis, and warfarin withdrawal. Ann Rheum Dis. 1985 Dec;44(12):823–825. doi: 10.1136/ard.44.12.823. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Asherson R. A., Khamashta M. A., Ordi-Ros J., Derksen R. H., Machin S. J., Barquinero J., Outt H. H., Harris E. N., Vilardell-Torres M., Hughes G. R. The "primary" antiphospholipid syndrome: major clinical and serological features. Medicine (Baltimore) 1989 Nov;68(6):366–374. [PubMed] [Google Scholar]
- BOWIE E. J., THOMPSON J. H., Jr, PASCUZZI C. A., OWEN C. A., Jr THROMBOSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS DESPITE CIRCULATING ANTICOAGULANTS. J Lab Clin Med. 1963 Sep;62:416–430. [PubMed] [Google Scholar]
- Bergman R., Lorber M., Lerner M., Brik R., Friedman-Birnbaum R. Anticardiolipin antibodies in Behçet's disease. J Dermatol. 1990 Mar;17(3):164–167. doi: 10.1111/j.1346-8138.1990.tb01619.x. [DOI] [PubMed] [Google Scholar]
- Candan I., Erol C., Sonel A., Akalin H. Behçet's disease: cardiac and pulmonary involvement. Eur Heart J. 1986 Nov;7(11):999–1002. doi: 10.1093/oxfordjournals.eurheartj.a062006. [DOI] [PubMed] [Google Scholar]
- Carreras L. O., Defreyn G., Machin S. J., Vermylen J., Deman R., Spitz B., Van Assche A. Arterial thrombosis, intrauterine death and "lupus" antiocoagulant: detection of immunoglobulin interfering with prostacyclin formation. Lancet. 1981 Jan 31;1(8214):244–246. doi: 10.1016/s0140-6736(81)92087-0. [DOI] [PubMed] [Google Scholar]
- Coppock M. A., Safford R. E., Danielson G. K. Intracardiac thrombosis, phospholipid antibodies, and two-chambered right ventricle. Br Heart J. 1988 Nov;60(5):455–458. doi: 10.1136/hrt.60.5.455. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hughes G. R., Asherson R. A., Khamashta M. A. Antiphospholipid syndrome: linking many specialties. Ann Rheum Dis. 1989 May;48(5):355–356. doi: 10.1136/ard.48.5.355. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hughes G. R., Harris N. N., Gharavi A. E. The anticardiolipin syndrome. J Rheumatol. 1986 Jun;13(3):486–489. [PubMed] [Google Scholar]
- Imai H., Sakakibara M., Yoshida K., Watanabe S., Masuda Y., Inagaki Y., Ikehira H., Fukuda N., Tateno Y. [Magnetic resonance imaging of cardiovascular thrombi]. J Cardiogr. 1985 Sep;15(3):681–694. [PubMed] [Google Scholar]
- Khamashta M. A., Wallington T. Management of the antiphospholipid syndrome. Ann Rheum Dis. 1991 Dec;50(12):959–962. doi: 10.1136/ard.50.12.959. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Leung W. H., Wong K. L., Lau C. P., Wong C. K., Liu H. W. Association between antiphospholipid antibodies and cardiac abnormalities in patients with systemic lupus erythematosus. Am J Med. 1990 Oct;89(4):411–419. doi: 10.1007/BF01453668. [DOI] [PubMed] [Google Scholar]
- Leventhal L. J., Borofsky M. A., Bergey P. D., Schumacher H. R., Jr Antiphospholipid antibody syndrome with right atrial thrombosis mimicking an atrial myxoma. Am J Med. 1989 Jul;87(1):111–113. doi: 10.1016/s0002-9343(89)80496-6. [DOI] [PubMed] [Google Scholar]
- Lubbe W. F., Asherson R. A. Intracardiac thrombus in systemic lupus erythematosus associated with lupus anticoagulant. Arthritis Rheum. 1988 Nov;31(11):1453–1454. doi: 10.1002/art.1780311122. [DOI] [PubMed] [Google Scholar]
- Mackworth-Young C. G., Loizou S., Walport M. J. Primary antiphospholipid syndrome: features of patients with raised anticardiolipin antibodies and no other disorder. Ann Rheum Dis. 1989 May;48(5):362–367. doi: 10.1136/ard.48.5.362. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Malia R. G., Kitchen S., Greaves M., Preston F. E. Inhibition of activated protein C and its cofactor protein S by antiphospholipid antibodies. Br J Haematol. 1990 Sep;76(1):101–107. doi: 10.1111/j.1365-2141.1990.tb07843.x. [DOI] [PubMed] [Google Scholar]
- Morton K. E., Gavaghan T. P., Krilis S. A., Daggard G. E., Baron D. W., Hickie J. B., Chesterman C. N. Coronary artery bypass graft failure--an autoimmune phenomenon? Lancet. 1986 Dec 13;2(8520):1353–1357. doi: 10.1016/s0140-6736(86)92004-0. [DOI] [PubMed] [Google Scholar]
- Raz I., Okon E., Chajek-Shaul T. Pulmonary manifestations in Behçet's syndrome. Chest. 1989 Mar;95(3):585–589. doi: 10.1378/chest.95.3.585. [DOI] [PubMed] [Google Scholar]
- Rosove M. H., Brewer P. M. Antiphospholipid thrombosis: clinical course after the first thrombotic event in 70 patients. Ann Intern Med. 1992 Aug 15;117(4):303–308. doi: 10.7326/0003-4819-117-4-303. [DOI] [PubMed] [Google Scholar]
- Stimmler M. M., Quismorio F. P., Jr, McGehee W. G., Boylen T., Sharma O. P. Anticardiolipin antibodies in acquired immunodeficiency syndrome. Arch Intern Med. 1989 Aug;149(8):1833–1835. [PubMed] [Google Scholar]
- Vanhaleweyk G., el-Ramahi K. M., Hazmi M., Sieck J. O., Zaman L., Fawzy M. Right atrial, right ventricular and left ventricular thrombi in (incomplete) Behçet's disease. Eur Heart J. 1990 Oct;11(10):957–959. doi: 10.1093/oxfordjournals.eurheartj.a059619. [DOI] [PubMed] [Google Scholar]