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. 1994 Sep;72(3):294–296. doi: 10.1136/hrt.72.3.294

Anticoagulation after intracoronary stent insertion.

M J Brack 1, P J Hubner 1, A H Gershlick 1
PMCID: PMC1025522  PMID: 7946786

Abstract

Stents rarely thrombose in the first 24 hours after implantation; secondly, heparin has some influence on the extrinsic pathway. Additionally, if too much heparin is present it interferes with the INR, and the half life of prothrombin suggests that the patient should be anticoagulated with heparin for up to 96 hours after starting warfarin. This is the evidence on which our standard protocol is based.

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Selected References

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  1. Brack M. J., More R. S., Hubner P. J., Gershlick A. H. Prothrombin fragment F1 + 2 concentrations for monitoring anticoagulation therapy with heparin. Int J Cardiol. 1993 Jan;38(1):57–61. doi: 10.1016/0167-5273(93)90204-t. [DOI] [PubMed] [Google Scholar]
  2. Béguin S., Lindhout T., Hemker H. C. The mode of action of heparin in plasma. Thromb Haemost. 1988 Dec 22;60(3):457–462. [PubMed] [Google Scholar]
  3. Choonara I. A., Malia R. G., Haynes B. P., Hay C. R., Cholerton S., Breckenridge A. M., Preston F. E., Park B. K. The relationship between inhibition of vitamin K1 2,3-epoxide reductase and reduction of clotting factor activity with warfarin. Br J Clin Pharmacol. 1988 Jan;25(1):1–7. doi: 10.1111/j.1365-2125.1988.tb03274.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Conway E. M., Bauer K. A., Barzegar S., Rosenberg R. D. Suppression of hemostatic system activation by oral anticoagulants in the blood of patients with thrombotic diatheses. J Clin Invest. 1987 Dec;80(6):1535–1544. doi: 10.1172/JCI113239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HELLEMANS J., VORLAT M., VERSTRAETE M. SURVIVAL TIME OF PROTHROMBIN AND FACTORS VII, IX AND X AFTER COMPLETELY SYNTHESIS BLOCKING DOSES OF COUMARIN DERIVATIVES. Br J Haematol. 1963 Oct;9:506–512. doi: 10.1111/j.1365-2141.1963.tb05475.x. [DOI] [PubMed] [Google Scholar]
  6. Hirsh J. Oral anticoagulant drugs. N Engl J Med. 1991 Jun 27;324(26):1865–1875. doi: 10.1056/NEJM199106273242606. [DOI] [PubMed] [Google Scholar]
  7. O'Reilly R. A., Aggeler P. M. Determinants of the response to oral anticoagulant drugs in man. Pharmacol Rev. 1970 Mar;22(1):35–96. [PubMed] [Google Scholar]
  8. Ofosu F. A., Hirsh J., Esmon C. T., Modi G. J., Smith L. M., Anvari N., Buchanan M. R., Fenton J. W., 2nd, Blajchman M. A. Unfractionated heparin inhibits thrombin-catalysed amplification reactions of coagulation more efficiently than those catalysed by factor Xa. Biochem J. 1989 Jan 1;257(1):143–150. doi: 10.1042/bj2570143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ofosu F. A., Sie P., Modi G. J., Fernandez F., Buchanan M. R., Blajchman M. A., Boneu B., Hirsh J. The inhibition of thrombin-dependent positive-feedback reactions is critical to the expression of the anticoagulant effect of heparin. Biochem J. 1987 Apr 15;243(2):579–588. doi: 10.1042/bj2430579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Schuler G., Hambrecht R., Schlierf G., Niebauer J., Hauer K., Neumann J., Hoberg E., Drinkmann A., Bacher F., Grunze M. Regular physical exercise and low-fat diet. Effects on progression of coronary artery disease. Circulation. 1992 Jul;86(1):1–11. doi: 10.1161/01.cir.86.1.1. [DOI] [PubMed] [Google Scholar]
  11. Strauss B. H., Serruys P. W., Bertrand M. E., Puel J., Meier B., Goy J. J., Kappenberger L., Rickards A. F., Sigwart U. Quantitative angiographic follow-up of the coronary Wallstent in native vessels and bypass grafts (European experience--March 1986 to March 1990). Am J Cardiol. 1992 Feb 15;69(5):475–481. doi: 10.1016/0002-9149(92)90989-c. [DOI] [PubMed] [Google Scholar]
  12. Thomas P., Fennerty A., Backhouse G., Bentley D. P., Campbell I. A., Routledge P. A. Monitoring effects of oral anticoagulants during treatment with heparin. Br Med J (Clin Res Ed) 1984 Jan 21;288(6412):191–191. doi: 10.1136/bmj.288.6412.191. [DOI] [PMC free article] [PubMed] [Google Scholar]

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