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. 1994 Sep;72(3 Suppl):S75–S80. doi: 10.1136/hrt.72.3_suppl.s75

Is neurohormonal activation a major determinant of the response to ACE inhibition in left ventricular dysfunction and heart failure?

Axel Sigurdsson 1, Karl Swedberg 1
PMCID: PMC1025598  PMID: 7946809

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Selected References

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  1. Anand I. S., Ferrari R., Kalra G. S., Wahi P. L., Poole-Wilson P. A., Harris P. C. Edema of cardiac origin. Studies of body water and sodium, renal function, hemodynamic indexes, and plasma hormones in untreated congestive cardiac failure. Circulation. 1989 Aug;80(2):299–305. doi: 10.1161/01.cir.80.2.299. [DOI] [PubMed] [Google Scholar]
  2. Bayliss J., Canepa-Anson R., Norell M. S., Poole-Wilson P., Sutton G. Vasodilatation with captopril and prazosin in chronic heart failure: double blind study at rest and on exercise. Br Heart J. 1986 Mar;55(3):265–273. doi: 10.1136/hrt.55.3.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bayliss J., Norell M., Canepa-Anson R., Sutton G., Poole-Wilson P. Untreated heart failure: clinical and neuroendocrine effects of introducing diuretics. Br Heart J. 1987 Jan;57(1):17–22. doi: 10.1136/hrt.57.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Broqvist M., Dahlström U., Karlberg B. E., Karlsson E., Marklund T. Neuroendocrine response in acute heart failure and the influence of treatment. Eur Heart J. 1989 Dec;10(12):1075–1083. doi: 10.1093/oxfordjournals.eurheartj.a059429. [DOI] [PubMed] [Google Scholar]
  5. Brown J. J., Davies D. L., Johnson V. W., Lever A. F., Robertson J. I. Renin relationships in congestive cardiac failure, treated and untreated. Am Heart J. 1970 Sep;80(3):329–342. doi: 10.1016/0002-8703(70)90098-0. [DOI] [PubMed] [Google Scholar]
  6. Chadda K., Goldstein S., Byington R., Curb J. D. Effect of propranolol after acute myocardial infarction in patients with congestive heart failure. Circulation. 1986 Mar;73(3):503–510. doi: 10.1161/01.cir.73.3.503. [DOI] [PubMed] [Google Scholar]
  7. Cleland J. G., Dargie H. J., Ball S. G., Gillen G., Hodsman G. P., Morton J. J., East B. W., Robertson I., Ford I., Robertson J. I. Effects of enalapril in heart failure: a double blind study of effects on exercise performance, renal function, hormones, and metabolic state. Br Heart J. 1985 Sep;54(3):305–312. doi: 10.1136/hrt.54.3.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cleland J. G., Dargie H. J., Hodsman G. P., Ball S. G., Robertson J. I., Morton J. J., East B. W., Robertson I., Murray G. D., Gillen G. Captopril in heart failure. A double blind controlled trial. Br Heart J. 1984 Nov;52(5):530–535. doi: 10.1136/hrt.52.5.530. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cody R. J., Atlas S. A., Laragh J. H. Renal responses to atrial natriuretic factor in patients with congestive heart failure. Eur Heart J. 1988 Jun;9 (Suppl H):29–33. doi: 10.1093/eurheartj/9.suppl_h.29. [DOI] [PubMed] [Google Scholar]
  10. Cody R. J., Franklin K. W., Kluger J., Laragh J. H. Mechanisms governing the postural response and baroreceptor abnormalities in chronic congestive heart failure: effects of acute and long-term converting-enzyme inhibition. Circulation. 1982 Jul;66(1):135–142. doi: 10.1161/01.cir.66.1.135. [DOI] [PubMed] [Google Scholar]
  11. Cohn J. N., Johnson G., Ziesche S., Cobb F., Francis G., Tristani F., Smith R., Dunkman W. B., Loeb H., Wong M. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med. 1991 Aug 1;325(5):303–310. doi: 10.1056/NEJM199108013250502. [DOI] [PubMed] [Google Scholar]
  12. Cohn J. N., Levine T. B., Olivari M. T., Garberg V., Lura D., Francis G. S., Simon A. B., Rector T. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med. 1984 Sep 27;311(13):819–823. doi: 10.1056/NEJM198409273111303. [DOI] [PubMed] [Google Scholar]
  13. Curtiss C., Cohn J. N., Vrobel T., Franciosa J. A. Role of the renin-angiotensin system in the systemic vasoconstriction of chronic congestive heart failure. Circulation. 1978 Nov;58(5):763–770. doi: 10.1161/01.cir.58.5.763. [DOI] [PubMed] [Google Scholar]
  14. Floras J. S., Hassan M. O., Jones J. V., Osikowska B. A., Sever P. S., Sleight P. Consequences of impaired arterial baroreflexes in essential hypertension: effects on pressor responses, plasma noradrenaline and blood pressure variability. J Hypertens. 1988 Jul;6(7):525–535. doi: 10.1097/00004872-198807000-00003. [DOI] [PubMed] [Google Scholar]
  15. Focaccio A., Volpe M., Ambrosio G., Lembo G., Pannain S., Rubattu S., Enea I., Pignalosa S., Chiariello M. Angiotensin II directly stimulates release of atrial natriuretic factor in isolated rabbit hearts. Circulation. 1993 Jan;87(1):192–198. doi: 10.1161/01.cir.87.1.192. [DOI] [PubMed] [Google Scholar]
  16. Francis G. S., Benedict C., Johnstone D. E., Kirlin P. C., Nicklas J., Liang C. S., Kubo S. H., Rudin-Toretsky E., Yusuf S. Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfunction (SOLVD). Circulation. 1990 Nov;82(5):1724–1729. doi: 10.1161/01.cir.82.5.1724. [DOI] [PubMed] [Google Scholar]
  17. Francis G. S., Rector T. S., Cohn J. N. Sequential neurohumoral measurements in patients with congestive heart failure. Am Heart J. 1988 Dec;116(6 Pt 1):1464–1468. doi: 10.1016/0002-8703(88)90729-6. [DOI] [PubMed] [Google Scholar]
  18. Gavras H., Kremer D., Brown J. J., Gray B., Lever A. F., MacAdam R. F., medina A., Morton J. J., Robertson J. I. Angiotensin- and norepinephrine-induced myocardial lesions: experimental and clinical studies in rabbits and man. Am Heart J. 1975 Mar;89(3):321–332. doi: 10.1016/0002-8703(75)90082-4. [DOI] [PubMed] [Google Scholar]
  19. Goldsmith S. R., Francis G. S., Cowley A. W., Jr, Levine T. B., Cohn J. N. Increased plasma arginine vasopressin levels in patients with congestive heart failure. J Am Coll Cardiol. 1983 Jun;1(6):1385–1390. doi: 10.1016/s0735-1097(83)80040-0. [DOI] [PubMed] [Google Scholar]
  20. Goldsmith S. R., Hasking G. J., Miller E. Angiotensin II and sympathetic activity in patients with congestive heart failure. J Am Coll Cardiol. 1993 Apr;21(5):1107–1113. doi: 10.1016/0735-1097(93)90232-p. [DOI] [PubMed] [Google Scholar]
  21. Gottlieb S. S., Kukin M. L., Ahern D., Packer M. Prognostic importance of atrial natriuretic peptide in patients with chronic heart failure. J Am Coll Cardiol. 1989 Jun;13(7):1534–1539. doi: 10.1016/0735-1097(89)90344-6. [DOI] [PubMed] [Google Scholar]
  22. Hirooka Y., Takeshita A., Imaizumi T., Suzuki S., Yoshida M., Ando S., Nakamura M. Attenuated forearm vasodilative response to intra-arterial atrial natriuretic peptide in patients with heart failure. Circulation. 1990 Jul;82(1):147–153. doi: 10.1161/01.cir.82.1.147. [DOI] [PubMed] [Google Scholar]
  23. Hirsch A. T., Talsness C. E., Smith A. D., Schunkert H., Ingelfinger J. R., Dzau V. J. Differential effects of captopril and enalapril on tissue renin-angiotensin systems in experimental heart failure. Circulation. 1992 Nov;86(5):1566–1574. doi: 10.1161/01.cir.86.5.1566. [DOI] [PubMed] [Google Scholar]
  24. Husain A. The chymase-angiotensin system in humans. J Hypertens. 1993 Nov;11(11):1155–1159. [PubMed] [Google Scholar]
  25. Karlsberg R. P., Cryer P. E., Roberts R. Serial plasma catecholamine response early in the course of clinical acute myocardial infarction: relationship to infarct extent and mortality. Am Heart J. 1981 Jul;102(1):24–29. doi: 10.1016/0002-8703(81)90408-7. [DOI] [PubMed] [Google Scholar]
  26. Kremer D., Lindop G., Brown W. C., Morton J. J., Robertson J. I. Angiotensin-induced myocardial necrosis and renal failure in the rabbit: distribution of lesions and severity in relation to plasma angiotensin II concentration and arterial pressure. Cardiovasc Res. 1981 Jan;15(1):43–46. doi: 10.1093/cvr/15.1.43. [DOI] [PubMed] [Google Scholar]
  27. Kubo S. H., Rector T. S., Bank A. J., Williams R. E., Heifetz S. M. Endothelium-dependent vasodilation is attenuated in patients with heart failure. Circulation. 1991 Oct;84(4):1589–1596. doi: 10.1161/01.cir.84.4.1589. [DOI] [PubMed] [Google Scholar]
  28. Lang C. C., Choy A. M., Struthers A. D. Atrial and brain natriuretic peptides: a dual natriuretic peptide system potentially involved in circulatory homeostasis. Clin Sci (Lond) 1992 Nov;83(5):519–527. doi: 10.1042/cs0830519. [DOI] [PubMed] [Google Scholar]
  29. Lanzillo J. J., Dasarathy Y., Stevens J., Fanburg B. L. Conversion of angiotensin-1 to angiotensin-2 by a latent endothelial cell peptidyl dipeptidase that is not angiotensin-converting enzyme. Biochem Biophys Res Commun. 1986 Jan 29;134(2):770–776. doi: 10.1016/s0006-291x(86)80487-9. [DOI] [PubMed] [Google Scholar]
  30. Lerman A., Gibbons R. J., Rodeheffer R. J., Bailey K. R., McKinley L. J., Heublein D. M., Burnett J. C., Jr Circulating N-terminal atrial natriuretic peptide as a marker for symptomless left-ventricular dysfunction. Lancet. 1993 May 1;341(8853):1105–1109. doi: 10.1016/0140-6736(93)93125-k. [DOI] [PubMed] [Google Scholar]
  31. Levine T. B., Francis G. S., Goldsmith S. R., Simon A. B., Cohn J. N. Activity of the sympathetic nervous system and renin-angiotensin system assessed by plasma hormone levels and their relation to hemodynamic abnormalities in congestive heart failure. Am J Cardiol. 1982 May;49(7):1659–1666. doi: 10.1016/0002-9149(82)90243-0. [DOI] [PubMed] [Google Scholar]
  32. McAlpine H. M., Morton J. J., Leckie B., Rumley A., Gillen G., Dargie H. J. Neuroendocrine activation after acute myocardial infarction. Br Heart J. 1988 Aug;60(2):117–124. doi: 10.1136/hrt.60.2.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. McMurray J. J., Lang C. C., MacLean D., McDevitt D. G., Struthers A. D. Neuroendocrine changes post myocardial infarction: effects of xamoterol. Am Heart J. 1990 Jul;120(1):56–62. doi: 10.1016/0002-8703(90)90160-y. [DOI] [PubMed] [Google Scholar]
  34. Michorowski B., Ceremuzyński L. The renin-angiotensin--aldosterone system and the clinical course of acute myocardial infarction. Eur Heart J. 1983 Apr;4(4):259–264. doi: 10.1093/oxfordjournals.eurheartj.a061457. [DOI] [PubMed] [Google Scholar]
  35. Motwani J. G., McAlpine H., Kennedy N., Struthers A. D. Plasma brain natriuretic peptide as an indicator for angiotensin-converting-enzyme inhibition after myocardial infarction. Lancet. 1993 May 1;341(8853):1109–1113. doi: 10.1016/0140-6736(93)93126-l. [DOI] [PubMed] [Google Scholar]
  36. Nabel E. G., Topol E. J., Galeana A., Ellis S. G., Bates E. R., Werns S. W., Walton J. A., Muller D. W., Schwaiger M., Pitt B. A randomized placebo-controlled trial of combined early intravenous captopril and recombinant tissue-type plasminogen activator therapy in acute myocardial infarction. J Am Coll Cardiol. 1991 Feb;17(2):467–473. doi: 10.1016/s0735-1097(10)80117-2. [DOI] [PubMed] [Google Scholar]
  37. Omland T., Aarsland T., Aakvaag A., Lie R. T., Dickstein K. Prognostic value of plasma atrial natriuretic factor, norepinephrine and epinephrine in acute myocardial infarction. Am J Cardiol. 1993 Aug 1;72(3):255–259. doi: 10.1016/0002-9149(93)90669-4. [DOI] [PubMed] [Google Scholar]
  38. Packer M. The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure. J Am Coll Cardiol. 1992 Jul;20(1):248–254. doi: 10.1016/0735-1097(92)90167-l. [DOI] [PubMed] [Google Scholar]
  39. Pfeffer M. A., Braunwald E., Moyé L. A., Basta L., Brown E. J., Jr, Cuddy T. E., Davis B. R., Geltman E. M., Goldman S., Flaker G. C. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N Engl J Med. 1992 Sep 3;327(10):669–677. doi: 10.1056/NEJM199209033271001. [DOI] [PubMed] [Google Scholar]
  40. Remes J., Tikkanen I., Fyhrquist F., Pyörälä K. Neuroendocrine activity in untreated heart failure. Br Heart J. 1991 May;65(5):249–255. doi: 10.1136/hrt.65.5.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Rouleau J. L., de Champlain J., Klein M., Bichet D., Moyé L., Packer M., Dagenais G. R., Sussex B., Arnold J. M., Sestier F. Activation of neurohumoral systems in postinfarction left ventricular dysfunction. J Am Coll Cardiol. 1993 Aug;22(2):390–398. doi: 10.1016/0735-1097(93)90042-y. [DOI] [PubMed] [Google Scholar]
  42. Schofer J., Hobuss M., Aschenberg W., Tews A. Acute and long-term haemodynamic and neurohumoral response to nisoldipine vs captopril in patients with heart failure: a randomized double-blind study. Eur Heart J. 1990 Aug;11(8):712–721. doi: 10.1093/oxfordjournals.eurheartj.a059786. [DOI] [PubMed] [Google Scholar]
  43. Sigurdsson A., Held P., Swedberg K. Short- and long-term neurohormonal activation following acute myocardial infarction. Am Heart J. 1993 Nov;126(5):1068–1076. doi: 10.1016/0002-8703(93)90656-t. [DOI] [PubMed] [Google Scholar]
  44. Sigurdsson A., Held P., Swedberg K., Wall B. Neurohormonal effects of early treatment with enalapril after acute myocardial infarction and the impact on left ventricular remodelling. Eur Heart J. 1993 Aug;14(8):1110–1117. doi: 10.1093/eurheartj/14.8.1110. [DOI] [PubMed] [Google Scholar]
  45. Sigurdsson A., Swedberg K., Ullman B. Effects of ramipril on the neurohormonal response to exercise in patients with mild or moderate congestive heart failure. Eur Heart J. 1994 Feb;15(2):247–254. doi: 10.1093/oxfordjournals.eurheartj.a060484. [DOI] [PubMed] [Google Scholar]
  46. Stevenson L. W., Sietsema K., Tillisch J. H., Lem V., Walden J., Kobashigawa J. A., Moriguchi J. Exercise capacity for survivors of cardiac transplantation or sustained medical therapy for stable heart failure. Circulation. 1990 Jan;81(1):78–85. doi: 10.1161/01.cir.81.1.78. [DOI] [PubMed] [Google Scholar]
  47. Svanegaard J., Angelo-Nielsen K., Pindborg T. Plasma concentration of atrial natriuretic peptide at admission and risk of cardiac death in patients with acute myocardial infarction. Br Heart J. 1992 Jul;68(1):38–42. doi: 10.1136/hrt.68.7.38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Swedberg K., Held P., Kjekshus J., Rasmussen K., Rydén L., Wedel H. Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction. Results of the Cooperative New Scandinavian Enalapril Survival Study II (CONSENSUS II) N Engl J Med. 1992 Sep 3;327(10):678–684. doi: 10.1056/NEJM199209033271002. [DOI] [PubMed] [Google Scholar]
  49. Thomas J. A., Marks B. H. Plasma norepinephrine in congestive heart failure. Am J Cardiol. 1978 Feb;41(2):233–243. doi: 10.1016/0002-9149(78)90162-5. [DOI] [PubMed] [Google Scholar]
  50. Tsutamoto T., Kanamori T., Morigami N., Sugimoto Y., Yamaoka O., Kinoshita M. Possibility of downregulation of atrial natriuretic peptide receptor coupled to guanylate cyclase in peripheral vascular beds of patients with chronic severe heart failure. Circulation. 1993 Jan;87(1):70–75. doi: 10.1161/01.cir.87.1.70. [DOI] [PubMed] [Google Scholar]
  51. Urata H., Healy B., Stewart R. W., Bumpus F. M., Husain A. Angiotensin II-forming pathways in normal and failing human hearts. Circ Res. 1990 Apr;66(4):883–890. doi: 10.1161/01.res.66.4.883. [DOI] [PubMed] [Google Scholar]
  52. Wenting G. J., Man in't veld A. J., Woittiez A. J., Boomsma F., Laird-Meeter K., Simoons M. L., Hugenholtz P. G., Schalekamp M. A. Effects of captopril in acute and chronic heart failure. Correlations with plasma levels of noradrenaline, renin, and aldosterone. Br Heart J. 1983 Jan;49(1):65–76. doi: 10.1136/hrt.49.1.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Wilber D. J., Baerman J., Olshansky B., Kall J., Kopp D. Adenosine-sensitive ventricular tachycardia. Clinical characteristics and response to catheter ablation. Circulation. 1993 Jan;87(1):126–134. doi: 10.1161/01.cir.87.1.126. [DOI] [PubMed] [Google Scholar]
  54. Zimmerman B. G. Actions of angiotensin on adrenergic nerve endings. Fed Proc. 1978 Feb;37(2):199–202. [PubMed] [Google Scholar]
  55. Zimmerman B. G. Adrenergic facilitation by angiotensin: does it serve a physiological function? Clin Sci (Lond) 1981 Apr;60(4):343–348. doi: 10.1042/cs0600343. [DOI] [PubMed] [Google Scholar]
  56. van Wijngaarden J., Tio R. A., van Gilst W. H., de Graeff P. A., de Langen C. D., Wesseling H. Basic pharmacology of ACE-inhibitors with respect to ischaemic heart disease: prostaglandins and bradykinin. Eur Heart J. 1990 Apr;11 (Suppl B):84–93. doi: 10.1093/eurheartj/11.suppl_b.84. [DOI] [PubMed] [Google Scholar]

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