Table A2.

Associations between self-reported working conditions and epigenetic age measures.

	PCHorvath			PCHannum			PCPhenoAge			PCGrimAge			DunedinPACE
	M1	M2	M3	M1	M2	M3	M1	M2	M3	M1	M2	M3	M1	M2	M3
High stress	−0.175	−0.294	−0.413	−0.276	−0.337	−0.448	−0.248	0.029	−0.227	0.473+	0.582*	0.178	0.012	0.022*	0.008
p-value	0.623	0.401	0.236	0.472	0.377	0.238	0.542	0.941	0.545	0.061	0.017	0.388	0.226	0.018	0.339
High physical effort	0.097	0.133	0.193	0.559	0.515	0.58	0.477	−0.384	−0.319	0.564*	0.031	−0.025	0.027*	0	−0.002
p-value	0.802	0.733	0.616	0.182	0.226	0.165	0.277	0.378	0.44	0.04	0.908	0.912	0.01	0.968	0.81
Long working hours	0.26	0.109	0.092	0.255	0.151	0.112	−0.087	0.177	0.169	0.518	0.615+	0.26	0.001	0.009	0.001
p-value	0.592	0.82	0.847	0.628	0.774	0.83	0.873	0.739	0.741	0.131	0.063	0.363	0.969	0.496	0.916
Controls for age & sex?	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Controls for race & education?		X	X		X	X		X	X		X	X		X	X
Controls for health			X			X			X			X			X
behaviors in 2016?
R-squared	0.237	0.274	0.298	0.243	0.262	0.293	0.281	0.331	0.406	0.449	0.492	0.644	0.018	0.123	0.259
AIC	8,043	7,994	7,968	8,229	8,208	8,170	8,359	8,280	8,148	7,178	7,087	6,660	−925	−1,054	−1,248
N	1,251	1,251	1,251	1,251	1,251	1,251	1,251	1,251	1,251	1,251	1,251	1,251	1,251	1,251	1,251

⁺p < 0.10, * p < 0.05, ** p < 0.01, *** p <0.001. Results are pooled across 10 imputations. Model 1 adjusts for age and sex. Model 2 additionally includes race/ethnicity and educational attainment. Model 3 additionally includes smoking status, alcohol consumption, physical inactivity, and Body Mass Index (BMI) category.