Skip to main content
NCBI home page
The Western Journal of Medicine logoLink to The Western Journal of Medicine
. 1988 Jun;148(6):685–690.

Therapeutic Dilemmas in Type II Diabetes Mellitus—Improving and Maintaining β-Cell and Insulin Sensitivity

PMCID: PMC1026207  PMID: 3051674

Abstract

These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California, San Francisco. Taken from transcriptions, they are prepared by Drs Homer A. Boushey, Professor of Medicine, and David G. Warnock, Associate Professor of Medicine, under the direction of Dr Lloyd H. Smith, Jr, Professor of Medicine and Associate Dean in the School of Medicine. Requests for reprints should be sent to the Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA 94143.

Full text

PDF
685

Images in this article

688Image
on p.688

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bevilacqua S., Bonadonna R., Buzzigoli G., Boni C., Ciociaro D., Maccari F., Giorico M. A., Ferrannini E. Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects. Metabolism. 1987 May;36(5):502–506. doi: 10.1016/0026-0495(87)90051-5. [DOI] [PubMed] [Google Scholar]
  2. Blackshear P. J., Shulman G. I., Roussell A. M., Nathan D. M., Minaker K. L., Rowe J. W., Robbins D. C., Cohen A. M. Metabolic response to three years of continuous, basal rate intravenous insulin infusion in type II diabetic patients. J Clin Endocrinol Metab. 1985 Oct;61(4):753–760. doi: 10.1210/jcem-61-4-753. [DOI] [PubMed] [Google Scholar]
  3. Bogardus C., Ravussin E., Robbins D. C., Wolfe R. R., Horton E. S., Sims E. A. Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus. Diabetes. 1984 Apr;33(4):311–318. doi: 10.2337/diab.33.4.311. [DOI] [PubMed] [Google Scholar]
  4. Bolaffi J. L., Heldt A., Lewis L. D., Grodsky G. M. The third phase of in vitro insulin secretion. Evidence for glucose insensitivity. Diabetes. 1986 Mar;35(3):370–373. doi: 10.2337/diab.35.3.370. [DOI] [PubMed] [Google Scholar]
  5. Bonner-Weir S., Trent D. F., Weir G. C. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest. 1983 Jun;71(6):1544–1553. doi: 10.1172/JCI110910. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Brenner B. M., Meyer T. W., Hostetter T. H. Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med. 1982 Sep 9;307(11):652–659. doi: 10.1056/NEJM198209093071104. [DOI] [PubMed] [Google Scholar]
  7. DeFronzo R. A., Ferrannini E., Koivisto V. New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus. Am J Med. 1983 Jan 17;74(1A):52–81. doi: 10.1016/0002-9343(83)90654-x. [DOI] [PubMed] [Google Scholar]
  8. Firth R. G., Bell P. M., Rizza R. A. Effects of tolazamide and exogenous insulin on insulin action in patients with non-insulin-dependent diabetes mellitus. N Engl J Med. 1986 May 15;314(20):1280–1286. doi: 10.1056/NEJM198605153142003. [DOI] [PubMed] [Google Scholar]
  9. Flier J. S., Cook K. S., Usher P., Spiegelman B. M. Severely impaired adipsin expression in genetic and acquired obesity. Science. 1987 Jul 24;237(4813):405–408. doi: 10.1126/science.3299706. [DOI] [PubMed] [Google Scholar]
  10. Fujioka S., Matsuzawa Y., Tokunaga K., Tarui S. Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism. 1987 Jan;36(1):54–59. doi: 10.1016/0026-0495(87)90063-1. [DOI] [PubMed] [Google Scholar]
  11. Garvey W. T., Olefsky J. M., Griffin J., Hamman R. F., Kolterman O. G. The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus. Diabetes. 1985 Mar;34(3):222–234. doi: 10.2337/diab.34.3.222. [DOI] [PubMed] [Google Scholar]
  12. Gavin J. R., 3rd, Roth J., Neville D. M., Jr, de Meyts P., Buell D. N. Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proc Natl Acad Sci U S A. 1974 Jan;71(1):84–88. doi: 10.1073/pnas.71.1.84. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Harris M. I., Hadden W. C., Knowler W. C., Bennett P. H. Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr. Diabetes. 1987 Apr;36(4):523–534. doi: 10.2337/diab.36.4.523. [DOI] [PubMed] [Google Scholar]
  14. Heine R. J., Bilo H. J., Fonk T., van der Veen E. A., van der Meer J. Absorption kinetics and action profiles of mixtures of short- and intermediate-acting insulins. Diabetologia. 1984 Dec;27(6):558–562. doi: 10.1007/BF00276967. [DOI] [PubMed] [Google Scholar]
  15. Karam J. H., Sanz N., Salamon E., Nolte M. S. Selective unresponsiveness of pancreatic beta-cells to acute sulfonylurea stimulation during sulfonylurea therapy in NIDDM. Diabetes. 1986 Dec;35(12):1314–1320. doi: 10.2337/diab.35.12.1314. [DOI] [PubMed] [Google Scholar]
  16. Kolata G. Diabetics should lose weight, avoid diet fads. Science. 1987 Jan 9;235(4785):163–164. doi: 10.1126/science.3798105. [DOI] [PubMed] [Google Scholar]
  17. Kolterman O. G., Gray R. S., Griffin J., Burstein P., Insel J., Scarlett J. A., Olefsky J. M. Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus. J Clin Invest. 1981 Oct;68(4):957–969. doi: 10.1172/JCI110350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Kosaka K., Kuzuya T., Akanuma Y., Hagura R. Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatment. Diabetologia. 1980 Jan;18(1):23–28. doi: 10.1007/BF01228297. [DOI] [PubMed] [Google Scholar]
  19. Rothwell N. J., Stock M. J. A role for brown adipose tissue in diet-induced thermogenesis. Nature. 1979 Sep 6;281(5726):31–35. doi: 10.1038/281031a0. [DOI] [PubMed] [Google Scholar]
  20. Sibley D. R., Strasser R. H., Benovic J. L., Daniel K., Lefkowitz R. J. Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. Proc Natl Acad Sci U S A. 1986 Dec;83(24):9408–9412. doi: 10.1073/pnas.83.24.9408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Simonson D. C., Delprato S., Castellino P., Groop L., DeFronzo R. A. Effect of glyburide on glycemic control, insulin requirement, and glucose metabolism in insulin-treated diabetic patients. Diabetes. 1987 Feb;36(2):136–146. doi: 10.2337/diab.36.2.136. [DOI] [PubMed] [Google Scholar]
  22. Stunkard A. J., Foch T. T., Hrubec Z. A twin study of human obesity. JAMA. 1986 Jul 4;256(1):51–54. [PubMed] [Google Scholar]
  23. Stunkard A. J., Sørensen T. I., Hanis C., Teasdale T. W., Chakraborty R., Schull W. J., Schulsinger F. An adoption study of human obesity. N Engl J Med. 1986 Jan 23;314(4):193–198. doi: 10.1056/NEJM198601233140401. [DOI] [PubMed] [Google Scholar]
  24. Ullrich A., Bell J. R., Chen E. Y., Herrera R., Petruzzelli L. M., Dull T. J., Gray A., Coussens L., Liao Y. C., Tsubokawa M. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. 1985 Feb 28-Mar 6Nature. 313(6005):756–761. doi: 10.1038/313756a0. [DOI] [PubMed] [Google Scholar]
  25. Vague P., Moulin J. P. The defective glucose sensitivity of the B cell in non insulin dependent diabetes. Improvement after twenty hours of normoglycaemia. Metabolism. 1982 Feb;31(2):139–142. doi: 10.1016/0026-0495(82)90125-1. [DOI] [PubMed] [Google Scholar]
  26. Ward W. K., Bolgiano D. C., McKnight B., Halter J. B., Porte D., Jr Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J Clin Invest. 1984 Oct;74(4):1318–1328. doi: 10.1172/JCI111542. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Yki-Järvinen H., Helve E., Koivisto V. A. Hyperglycemia decreases glucose uptake in type I diabetes. Diabetes. 1987 Aug;36(8):892–896. doi: 10.2337/diab.36.8.892. [DOI] [PubMed] [Google Scholar]
  28. Zatz R., Brenner B. M. Pathogenesis of diabetic microangiopathy. The hemodynamic view. Am J Med. 1986 Mar;80(3):443–453. doi: 10.1016/0002-9343(86)90719-9. [DOI] [PubMed] [Google Scholar]

Articles from Western Journal of Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES