Skip to main content
NCBI home page
The Western Journal of Medicine logoLink to The Western Journal of Medicine
. 1988 Jul;149(1):40–42.

Delta Hepatitis in Denver

William G Rector Jr, Sugantha Govindarajan, Kent A Penley, Franklyn N Judson
PMCID: PMC1026242  PMID: 3407160

Abstract

The prevalence of hepatitis D virus (HDV) infection in patients with hepatitis B virus (HBV) infection in the mid-United States is not well defined. We tested 65 patients seen between 1983 and 1986 with HBV infection in Denver for evidence of coexisting HDV infection. Five patients had anti-delta (δ) antibody. The prevalence of HDV infection was higher in patients with chronic hepatitis B (4/37) than in patients with acute hepatitis B (1/28). The prevalence of HDV infection in male homosexuals (3/32) was similar to reported figures, but the incidence of δ-infection in intravenous drug users in Denver was usually low (1/16). In comparison to Los Angeles, New York, southern Italy, and Sweden, Denver appears to have a low incidence of HDV infection, which probably reflects its low prevalence in the drug-using population.

Full text

PDF
40

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arico S., Aragona M., Rizzetto M., Caredda F., Zanetti A., Marinucci G., Diana S., Farci P., Arnone M., Caporaso N. Clinical significance of antibody to the hepatitis delta virus in symptomless HBsAg carriers. Lancet. 1985 Aug 17;2(8451):356–358. doi: 10.1016/s0140-6736(85)92497-3. [DOI] [PubMed] [Google Scholar]
  2. De Cock K. M., Govindarajan S., Chin K. P., Redeker A. G. Delta hepatitis in the Los Angeles area: a report of 126 cases. Ann Intern Med. 1986 Jul;105(1):108–114. doi: 10.7326/0003-4819-105-1-108. [DOI] [PubMed] [Google Scholar]
  3. DeCock K. M., Jones B., Govindarajan S., Redeker A. G. Prevalence of hepatitis delta (delta) virus infection. A seroepidemiologic study. West J Med. 1988 Mar;148(3):307–309. [PMC free article] [PubMed] [Google Scholar]
  4. Francis D. P., Hadler S. C., Thompson S. E., Maynard J. E., Ostrow D. G., Altman N., Braff E. H., O'Malley P., Hawkins D., Judson F. N. The prevention of hepatitis B with vaccine. Report of the centers for disease control multi-center efficacy trial among homosexual men. Ann Intern Med. 1982 Sep;97(3):362–366. doi: 10.7326/0003-4819-97-3-362. [DOI] [PubMed] [Google Scholar]
  5. Govindarajan S., Chin K. P., Redeker A. G., Peters R. L. Fulminant B viral hepatitis: role of delta agent. Gastroenterology. 1984 Jun;86(6):1417–1420. [PubMed] [Google Scholar]
  6. Govindarajan S., Kanel G. C., Peters R. L. Prevalence of delta-antibody among chronic hepatitis B virus infected patients in the Los Angeles area: its correlation with liver biopsy diagnosis. Gastroenterology. 1983 Jul;85(1):160–162. [PubMed] [Google Scholar]
  7. Hadler S. C., De Monzon M., Ponzetto A., Anzola E., Rivero D., Mondolfi A., Bracho A., Francis D. P., Gerber M. A., Thung S. Delta virus infection and severe hepatitis. An epidemic in the Yucpa Indians of Venezuela. Ann Intern Med. 1984 Mar;100(3):339–344. doi: 10.7326/0003-4819-100-3-339. [DOI] [PubMed] [Google Scholar]
  8. Hansson B. G., Moestrup T., Widell A., Nordenfelt E. Infection with delta agent in Sweden: introduction of a new hepatitis agent. J Infect Dis. 1982 Oct;146(4):472–478. doi: 10.1093/infdis/146.4.472. [DOI] [PubMed] [Google Scholar]
  9. Hess G., Bienzle U., Slusarczyk J., Hansson B. G., Meyer zum Büschenfelde K. H. Hepatitis B virus and delta infection in male homosexuals. Liver. 1986 Feb;6(1):13–16. doi: 10.1111/j.1600-0676.1986.tb00262.x. [DOI] [PubMed] [Google Scholar]
  10. Jacobson I. M., Dienstag J. L., Werner B. G., Brettler D. B., Levine P. H., Mushahwar I. K. Epidemiology and clinical impact of hepatitis D virus (delta) infection. Hepatology. 1985 Mar-Apr;5(2):188–191. doi: 10.1002/hep.1840050205. [DOI] [PubMed] [Google Scholar]
  11. Lindh G., Weiland O., Svedmyr A., Glaumann H., Hansson B. G. Long-term follow-up of 60 patients with chronic hepatitis B. I. Seroconversion in the hepatitis B e-system, frequency of delta infection and histological outcome. Liver. 1986 Feb;6(1):7–12. doi: 10.1111/j.1600-0676.1986.tb00261.x. [DOI] [PubMed] [Google Scholar]
  12. Maggiore G., Hadchouel M., Sessa F., Vinci M., Craxì A., Marzani M. D., De Giacomo C., Alagille D. A retrospective study of the role of delta agent infection in children with HBsAg-positive chronic hepatitis. Hepatology. 1985 Jan-Feb;5(1):7–9. doi: 10.1002/hep.1840050103. [DOI] [PubMed] [Google Scholar]
  13. Nath N., Mushahwar I. K., Fang C. T., Berberian H., Dodd R. Y. Antibodies to delta antigen in asymptomatic hepatitis B surface antigen-reactive blood donors in the United States and their association with other markers of hepatitis B virus. Am J Epidemiol. 1985 Aug;122(2):218–225. doi: 10.1093/oxfordjournals.aje.a114092. [DOI] [PubMed] [Google Scholar]
  14. Raimondo G., Smedile A., Gallo L., Balbo A., Ponzetto A., Rizzetto M. Multicentre study of prevalence of HBV-associated delta infection and liver disease in drug-addicts. Lancet. 1982 Jan 30;1(8266):249–251. doi: 10.1016/s0140-6736(82)90976-x. [DOI] [PubMed] [Google Scholar]
  15. Rizzetto M., Canese M. G., Aricò S., Crivelli O., Trepo C., Bonino F., Verme G. Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers. Gut. 1977 Dec;18(12):997–1003. doi: 10.1136/gut.18.12.997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rizzetto M., Purcell R. H., Gerin J. L. Epidemiology of HBV-associated delta agent: geographical distribution of anti-delta and prevalence in polytransfused HBsAg carriers. Lancet. 1980 Jun 7;1(8180):1215–1218. doi: 10.1016/s0140-6736(80)91678-5. [DOI] [PubMed] [Google Scholar]
  17. Rizzetto M., Shih J. W., Gocke D. J., Purcell R. H., Verme G., Gerin J. L. Incidence and significance of antibodies to delta antigen in hepatitis B virus infection. Lancet. 1979 Nov 10;2(8150):986–990. doi: 10.1016/s0140-6736(79)92561-3. [DOI] [PubMed] [Google Scholar]
  18. Rizzetto M. The delta agent. Hepatology. 1983 Sep-Oct;3(5):729–737. doi: 10.1002/hep.1840030518. [DOI] [PubMed] [Google Scholar]
  19. Schreeder M. T., Thompson S. E., Hadler S. C., Berquist K. R., Zaidi A., Maynard J. E., Ostrow D., Judson F. N., Braff E. H., Nylund T. Hepatitis B in homosexual men: prevalence of infection and factors related to transmission. J Infect Dis. 1982 Jul;146(1):7–15. doi: 10.1093/infdis/146.1.7. [DOI] [PubMed] [Google Scholar]
  20. Shiels M. T., Czaja A. J., Taswell H. F., Gerin J. L., Purcell R. H., Ludwig J., Rakela J., Nelson C. A. Frequency and significance of delta antibody in acute and chronic hepatitis B. A United States experience. Gastroenterology. 1985 Dec;89(6):1230–1234. doi: 10.1016/0016-5085(85)90637-7. [DOI] [PubMed] [Google Scholar]
  21. Smedile A., Farci P., Verme G., Caredda F., Cargnel A., Caporaso N., Dentico P., Trepo C., Opolon P., Gimson A. Influence of delta infection on severity of hepatitis B. Lancet. 1982 Oct 30;2(8305):945–947. doi: 10.1016/s0140-6736(82)90156-8. [DOI] [PubMed] [Google Scholar]
  22. Smedile A., Lavarini C., Crivelli O., Raimondo G., Fassone M., Rizzetto M. Radioimmunoassay detection of IgM antibodies to the HBV-associated delta (delta) antigen:" clinical significance in delta infection. J Med Virol. 1982;9(2):131–138. doi: 10.1002/jmv.1890090208. [DOI] [PubMed] [Google Scholar]
  23. Smedile A., Lavarini C., Farci P., Aricò S., Marinucci G., Dentico P., Giuliani G., Cargnel A., Del Vecchio Blanco C., Rizzetto M. Epidemiologic patterns of infection with the hepatitis B virus-associated delta agent in Italy. Am J Epidemiol. 1983 Feb;117(2):223–229. doi: 10.1093/oxfordjournals.aje.a113533. [DOI] [PubMed] [Google Scholar]
  24. Tassopoulos N. C., Sjogren M. H., Ticehurst J. R., Engle R. E., Roumeliotou-Karayannis A., Gerin J. L., Purcell R. H., Papaevangelou G. Significance of IgM antibody to hepatitis B core antigen in a Greek population with chronic hepatitis B virus infection. Liver. 1986 Oct;6(5):275–280. doi: 10.1111/j.1600-0676.1986.tb00291.x. [DOI] [PubMed] [Google Scholar]
  25. Thomas H. C. The delta agent comes of age. Gut. 1985 Jan;26(1):1–3. doi: 10.1136/gut.26.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Weller I. V., Karayiannis P., Lok A. S., Montano L., Bamber M., Thomas H. C., Sherlock S. Significance of delta agent infection in chronic hepatitis B virus infection: a study in British carriers. Gut. 1983 Nov;24(11):1061–1063. doi: 10.1136/gut.24.11.1061. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Western Journal of Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES