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. Author manuscript; available in PMC: 2023 Jun 14.
Published in final edited form as: Chembiochem. 2021 Nov 5;23(1):e202100491. doi: 10.1002/cbic.202100491

Figure 2.

Figure 2.

(a) Electrostatic potential map comparing malonyl and a malonyltetrazole isostere. (b) Synthesis of a tetrazole isostere of malonyllysine amino acid. i) 4 M HCl, THF, 99%; ii) Cyanoacetic acid, DCC, DCM, 20%; iii) NaN3, ZnBr2, H2O/iPrOH (2:1), reflux, 30%.