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. 1989 Feb;150(2):163–164.

Screening laboratory tests for Crohn's disease.

D W Thomas, F R Sinatra
PMCID: PMC1026327  PMID: 2783220

Abstract

The prevalence of abnormal values of initial screening laboratory tests was assessed for 24 children who eventually proved to have Crohn's disease. The screening tests included in this analysis were fecal alpha 1-antitrypsin (FA) concentration, erythrocyte sedimentation rate (ESR), total leukocyte count, serum albumin level, hemoglobin concentration, and qualitative testing of stool for the presence of blood. Of the 24 patients, 21 had abnormal FA values, 17 had anemia, 19 had an increased ESR, 14 had hypoalbuminemia, rectal bleeding was found in 8, and none had leukocytosis. All 24 patients had at least one abnormal screening test value; the most frequently abnormal result was the FA concentration. Pediatric patients without elevated FA values, anemia, a high ESR, bloody stools, or hypoalbuminemia are unlikely to have active Crohn's disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beeken W. L. Absorptive defects in young people with regional enteritis. Pediatrics. 1973 Jul;52(1):69–74. [PubMed] [Google Scholar]
  2. Beeken W. L., Busch H. J., Sylwester D. L. Intestinal protein loss in Crohn's disease. Gastroenterology. 1972 Feb;62(2):207–215. [PubMed] [Google Scholar]
  3. Dinari G., Rosenbach Y., Zahavi I., Sivan Y., Nitzan M. Random fecal alpha 1-antitrypsin excretion in children with intestinal disorders. Am J Dis Child. 1984 Oct;138(10):971–973. doi: 10.1001/archpedi.1984.02140480073022. [DOI] [PubMed] [Google Scholar]
  4. Florent C., L'Hirondel C., Desmazures C., Aymes C., Bernier J. J. Intestinal clearance of alpha 1-antitrypsin. A sensitive method for the detection of protein-losing enteropathy. Gastroenterology. 1981 Oct;81(4):777–780. [PubMed] [Google Scholar]
  5. Florent C., Vidon N., Flourié B., Carmantrand A., Zerbani A., Maurel M., Bernier J. J. Gastric clearance of alpha-1-antitrypsin under cimetidine perfusion. New test to detect protein-losing gastropathy? Dig Dis Sci. 1986 Jan;31(1):12–15. doi: 10.1007/BF01347903. [DOI] [PubMed] [Google Scholar]
  6. Grill B. B., Hillemeier A. C., Gryboski J. D. Fecal alpha 1-antitrypsin clearance in patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 1984;3(1):56–61. doi: 10.1097/00005176-198401000-00013. [DOI] [PubMed] [Google Scholar]
  7. Gryboski J. D., Spiro H. M. Prognosis in children with Crohn's disease. Gastroenterology. 1978 May;74(5 Pt 1):807–817. [PubMed] [Google Scholar]
  8. Hill R. E., Hercz A., Corey M. L., Gilday D. L., Hamilton J. R. Fecal clearance of alpha 1-antitrypsin: a reliable measure of enteric protein loss in children. J Pediatr. 1981 Sep;99(3):416–418. doi: 10.1016/s0022-3476(81)80332-0. [DOI] [PubMed] [Google Scholar]
  9. Hoffman H. D., Hanekom C. Random faecal alpha-1-antitrypsin excretion in children with acute diarrhoea. J Trop Pediatr. 1987 Dec;33(6):299–301. doi: 10.1093/tropej/33.6.299. [DOI] [PubMed] [Google Scholar]
  10. Magazzù G., Jacono G., Di Pasquale G., Sferlazzas C., Tedeschi A., Santoro S., Nibali S. C., Musso F., Balsamo V. Reliability and usefulness of random fecal alpha 1-antitrypsin concentration: further simplification of the method. J Pediatr Gastroenterol Nutr. 1985 Jun;4(3):402–407. doi: 10.1097/00005176-198506000-00014. [DOI] [PubMed] [Google Scholar]
  11. Mäki M., Harmoinen A., Vesikari T., Visakorpi J. K. Faecal excretion of alpha-1-antitrypsin in acute diarrhoea. Arch Dis Child. 1982 Feb;57(2):154–156. doi: 10.1136/adc.57.2.154. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Shulman R. J., Buffone G., Wise L. Enteric protein loss in necrotizing enterocolitis as measured by fecal alpha 1-antitrypsin excretion. J Pediatr. 1985 Aug;107(2):287–289. doi: 10.1016/s0022-3476(85)80152-9. [DOI] [PubMed] [Google Scholar]
  13. Thomas D. W., Sinatra F. R., Merritt R. J. Fecal alpha 1-antitrypsin excretion in young people with Crohn's disease. J Pediatr Gastroenterol Nutr. 1983;2(3):491–496. doi: 10.1097/00005176-198302030-00017. [DOI] [PubMed] [Google Scholar]
  14. Thomas D. W., Sinatra F. R., Merritt R. J. Random fecal alpha-1-antitrypsin concentration in children with gastrointestinal disease. Gastroenterology. 1981 Apr;80(4):776–782. [PubMed] [Google Scholar]
  15. Weisdorf S. A., Salati L. M., Longsdorf J. A., Ramsay N. K., Sharp H. L. Graft-versus-host disease of the intestine: a protein losing enteropathy characterized by fecal alpha 1-antitrypsin. Gastroenterology. 1983 Nov;85(5):1076–1081. [PubMed] [Google Scholar]

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