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. 1989 Dec;151(6):638–643.

Bone marrow transplantation. Part I--Allogeneic.

N J Chao, K G Blume
PMCID: PMC1026744  PMID: 2694621

Abstract

Major progress in experimental and clinical research has made allogeneic bone marrow transplantation a highly effective therapy for a variety of malignant and nonmalignant diseases. Allogeneic bone marrow transplantation from histocompatible donors is now the therapy of choice for some of these disorders. We review in part I the history, technical approach, complications, and the results achievable with this therapeutic approach. Further experimentation and future goals are also discussed.

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Selected References

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  1. Anasetti C., Doney K. C., Storb R., Meyers J. D., Farewell V. T., Buckner C. D., Appelbaum F. R., Sullivan K. M., Clift R. A., Deeg H. J. Marrow transplantation for severe aplastic anemia. Long-term outcome in fifty "untransfused" patients. Ann Intern Med. 1986 Apr;104(4):461–466. doi: 10.7326/0003-4819-104-4-461. [DOI] [PubMed] [Google Scholar]
  2. Antin J. H., Ginsburg D., Smith B. R., Nathan D. G., Orkin S. H., Rappeport J. M. Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria: eradication of the PNH clone and documentation of complete lymphohematopoietic engraftment. Blood. 1985 Dec;66(6):1247–1250. [PubMed] [Google Scholar]
  3. Appelbaum F. R., Fisher L. D., Thomas E. D. Chemotherapy v marrow transplantation for adults with acute nonlymphocytic leukemia: a five-year follow-up. Blood. 1988 Jul;72(1):179–184. [PubMed] [Google Scholar]
  4. Arthur C. K., Apperley J. F., Guo A. P., Rassool F., Gao L. M., Goldman J. M. Cytogenetic events after bone marrow transplantation for chronic myeloid leukemia in chronic phase. Blood. 1988 May;71(5):1179–1186. [PubMed] [Google Scholar]
  5. Atkinson K., Storb R., Prentice R. L., Weiden P. L., Witherspoon R. P., Sullivan K., Noel D., Thomas E. D. Analysis of late infections in 89 long-term survivors of bone marrow transplantation. Blood. 1979 Apr;53(4):720–731. [PubMed] [Google Scholar]
  6. Bartram C. R., Janssen J. W., Becher R., de Klein A., Grosveld G. Persistence of chronic myelocytic leukemia despite deletion of rearranged bcr/c-abl sequences in blast crisis. J Exp Med. 1986 Nov 1;164(5):1389–1396. doi: 10.1084/jem.164.5.1389. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bensinger W. I., Buckner C. D., Clift R. A., Thomas E. D. Plasma exchange and plasma modification for the removal of anti-red cell antibodies prior to ABO-incompatible marrow transplant. J Clin Apher. 1987;3(3):174–177. doi: 10.1002/jca.2920030310. [DOI] [PubMed] [Google Scholar]
  8. Berenson R. J., Andrews R. G., Bensinger W. I., Kalamasz D., Knitter G., Buckner C. D., Bernstein I. D. Antigen CD34+ marrow cells engraft lethally irradiated baboons. J Clin Invest. 1988 Mar;81(3):951–955. doi: 10.1172/JCI113409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Blume K. G., Forman S. J., O'Donnell M. R., Doroshow J. H., Krance R. A., Nademanee A. P., Snyder D. S., Schmidt G. M., Fahey J. L., Metter G. E. Total body irradiation and high-dose etoposide: a new preparatory regimen for bone marrow transplantation in patients with advanced hematologic malignancies. Blood. 1987 Apr;69(4):1015–1020. [PubMed] [Google Scholar]
  10. Blume K. G., Forman S. J., Snyder D. S., Nademanee A. P., O'Donnell M. R., Fahey J. L., Krance R. A., Sniecinski I. J., Stock A. D., Findley D. O. Allogeneic bone marrow transplantation for acute lymphoblastic leukemia during first complete remission. Transplantation. 1987 Mar;43(3):389–392. doi: 10.1097/00007890-198703000-00014. [DOI] [PubMed] [Google Scholar]
  11. Bolger G. B., Sullivan K. M., Spence A. M., Appelbaum F. R., Johnston R., Sanders J. E., Deeg H. J., Witherspoon R. P., Doney K. C., Nims J. Myasthenia gravis after allogeneic bone marrow transplantation: relationship to chronic graft-versus-host disease. Neurology. 1986 Aug;36(8):1087–1091. doi: 10.1212/wnl.36.8.1087. [DOI] [PubMed] [Google Scholar]
  12. Bortin M. M., Gale R. P., Rimm A. A. Allogeneic bone marrow transplantation for 144 patients with severe aplastic anemia. JAMA. 1981 Mar 20;245(11):1132–1139. [PubMed] [Google Scholar]
  13. Bortin M. M., Rimm A. A. Severe combined immunodeficiency disease. Characterization of the disease and results of transplantation. JAMA. 1977 Aug 15;238(7):591–600. [PubMed] [Google Scholar]
  14. Braine H. G., Sensenbrenner L. L., Wright S. K., Tutschka P. J., Saral R., Santos G. W. Bone marrow transplantation with major ABO blood group incompatibility using erythrocyte depletion of marrow prior to infusion. Blood. 1982 Aug;60(2):420–425. [PubMed] [Google Scholar]
  15. Champlin R. E., Ho W. G., Gale R. P., Winston D., Selch M., Mitsuyasu R., Lenarsky C., Elashoff R., Zighelboim J., Feig S. A. Treatment of acute myelogenous leukemia. A prospective controlled trial of bone marrow transplantation versus consolidation chemotherapy. Ann Intern Med. 1985 Mar;102(3):285–291. doi: 10.7326/0003-4819-102-3-285. [DOI] [PubMed] [Google Scholar]
  16. Champlin R. E., Ho W. G., Gale R. P., Winston D., Selch M., Mitsuyasu R., Lenarsky C., Elashoff R., Zighelboim J., Feig S. A. Treatment of acute myelogenous leukemia. A prospective controlled trial of bone marrow transplantation versus consolidation chemotherapy. Ann Intern Med. 1985 Mar;102(3):285–291. doi: 10.7326/0003-4819-102-3-285. [DOI] [PubMed] [Google Scholar]
  17. Coccia P. F., Krivit W., Cervenka J., Clawson C., Kersey J. H., Kim T. H., Nesbit M. E., Ramsay N. K., Warkentin P. I., Teitelbaum S. L. Successful bone-marrow transplantation for infantile malignant osteopetrosis. N Engl J Med. 1980 Mar 27;302(13):701–708. doi: 10.1056/NEJM198003273021301. [DOI] [PubMed] [Google Scholar]
  18. Corson S. L., Sullivan K., Batzer F., August C., Storb R., Thomas E. D. Gynecologic manifestations of chronic graft-versus-host disease. Obstet Gynecol. 1982 Oct;60(4):488–492. [PubMed] [Google Scholar]
  19. Deeg H. J., Self S., Storb R., Doney K., Appelbaum F. R., Witherspoon R. P., Sullivan K. M., Sheehan K., Sanders J., Mickelson E. Decreased incidence of marrow graft rejection in patients with severe aplastic anemia: changing impact of risk factors. Blood. 1986 Dec;68(6):1363–1368. [PubMed] [Google Scholar]
  20. Deeg H. J., Storb R., Thomas E. D., Appelbaum F., Buckner C. D., Clift R. A., Doney K., Johnson L., Sanders J. E., Stewart P. Fanconi's anemia treated by allogeneic marrow transplantation. Blood. 1983 May;61(5):954–959. [PubMed] [Google Scholar]
  21. Doney K., Buckner C. D., Sale G. E., Ramberg R., Boyd C., Thomas E. D. Treatment of chronic granulocytic leukemia by chemotherapy, total body irradiation and allogeneic bone marrow transplantation. Exp Hematol. 1978 Oct;6(9):738–747. [PubMed] [Google Scholar]
  22. Dreazen O., Klisak I., Rassool F., Goldman J. M., Sparkes R. S., Gale R. P. Do oncogenes determine clinical features in chronic myeloid leukaemia? Lancet. 1987 Jun 20;1(8547):1402–1405. doi: 10.1016/s0140-6736(87)90594-0. [DOI] [PubMed] [Google Scholar]
  23. Eliason J. F. Studies on the role of serum in long-term bone marrow cell cultures. Exp Hematol. 1983 Feb;11(2):98–106. [PubMed] [Google Scholar]
  24. Emanuel D., Cunningham I., Jules-Elysee K., Brochstein J. A., Kernan N. A., Laver J., Stover D., White D. A., Fels A., Polsky B. Cytomegalovirus pneumonia after bone marrow transplantation successfully treated with the combination of ganciclovir and high-dose intravenous immune globulin. Ann Intern Med. 1988 Nov 15;109(10):777–782. doi: 10.7326/0003-4819-109-10-777. [DOI] [PubMed] [Google Scholar]
  25. Estrov Z., Dubé I. D., Chan H. S., Freedman M. H. Residual juvenile chronic myelogenous leukemia cells detected in peripheral blood during clinical remission. Blood. 1987 Nov;70(5):1466–1469. [PubMed] [Google Scholar]
  26. Fefer A., Freeman H., Storb R., Hill J., Singer J., Edwards A., Thomas E. Paroxysmal nocturanal hemoglobinuria and marrow failure treated by infusion of marrow from an identical twin. Ann Intern Med. 1976 Jun;84(6):692–695. doi: 10.7326/0003-4819-84-6-692. [DOI] [PubMed] [Google Scholar]
  27. Fischer A., Griscelli C., Friedrich W., Kubanek B., Levinsky R., Morgan G., Vossen J., Wagemaker G., Landais P. Bone-marrow transplantation for immunodeficiencies and osteopetrosis: European survey, 1968-1985. Lancet. 1986 Nov 8;2(8515):1080–1084. doi: 10.1016/s0140-6736(86)90477-0. [DOI] [PubMed] [Google Scholar]
  28. Forman S. J., Krance R. A., O'Donnell M. R., Nademanee A. P., Snyder D. S., Fahey J. L., Schmidt G. M., Zaia J. A., Lipsett J. A., Findley D. O. Bone marrow transplantation for acute nonlymphoblastic leukemia during first complete remission. An analysis of prognostic factors. Transplantation. 1987 May;43(5):650–653. doi: 10.1097/00007890-198705000-00009. [DOI] [PubMed] [Google Scholar]
  29. Gale R. P., Feig S., Ho W., Falk P., Rippee C., Sparkes R. ABO blood group system and bone marrow transplantation. Blood. 1977 Aug;50(2):185–194. [PubMed] [Google Scholar]
  30. Gale R. P., Sparkes R. S., Golde D. W. Bone marrow origin of hepatic macrophages (Kupffer cells) in humans. Science. 1978 Sep 8;201(4359):937–938. doi: 10.1126/science.356266. [DOI] [PubMed] [Google Scholar]
  31. Gatti R. A., Meuwissen H. J., Allen H. D., Hong R., Good R. A. Immunological reconstitution of sex-linked lymphopenic immunological deficiency. Lancet. 1968 Dec 28;2(7583):1366–1369. doi: 10.1016/s0140-6736(68)92673-1. [DOI] [PubMed] [Google Scholar]
  32. Gaynor J., Chapman D., Little C., McKenzie S., Miller W., Andreeff M., Arlin Z., Berman E., Kempin S., Gee T. A cause-specific hazard rate analysis of prognostic factors among 199 adults with acute lymphoblastic leukemia: the Memorial Hospital experience since 1969. J Clin Oncol. 1988 Jun;6(6):1014–1030. doi: 10.1200/JCO.1988.6.6.1014. [DOI] [PubMed] [Google Scholar]
  33. Geller R. B., Vogelsang G. B., Wingard J. R., Yeager A. M., Burns W. H., Santos G. W., Saral R. Successful marrow transplantation for acute myelocytic leukemia following therapy for Hodgkin's disease. J Clin Oncol. 1988 Oct;6(10):1558–1561. doi: 10.1200/JCO.1988.6.10.1558. [DOI] [PubMed] [Google Scholar]
  34. Gluckman E., Berger R., Dutreix J. Bone marrow transplantation for Fanconi anemia. Semin Hematol. 1984 Jan;21(1):20–26. [PubMed] [Google Scholar]
  35. Glucksberg H., Storb R., Fefer A., Buckner C. D., Neiman P. E., Clift R. A., Lerner K. G., Thomas E. D. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation. 1974 Oct;18(4):295–304. doi: 10.1097/00007890-197410000-00001. [DOI] [PubMed] [Google Scholar]
  36. Goldman J. M., Gale R. P., Horowitz M. M., Biggs J. C., Champlin R. E., Gluckman E., Hoffmann R. G., Jacobsen S. J., Marmont A. M., McGlave P. B. Bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Increased risk for relapse associated with T-cell depletion. Ann Intern Med. 1988 Jun;108(6):806–814. doi: 10.7326/0003-4819-108-6-806. [DOI] [PubMed] [Google Scholar]
  37. Goldman J. M., Gale R. P., Horowitz M. M., Biggs J. C., Champlin R. E., Gluckman E., Hoffmann R. G., Jacobsen S. J., Marmont A. M., McGlave P. B. Bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Increased risk for relapse associated with T-cell depletion. Ann Intern Med. 1988 Jun;108(6):806–814. doi: 10.7326/0003-4819-108-6-806. [DOI] [PubMed] [Google Scholar]
  38. Gratwohl A. A., Gratwhol A. A., Moutsopoulos H. M., Chused T. M., Akizuki M., Wolf R. O., Sweet J. B., Deisseroth A. B. Sjögren-type syndrome after allogeneic bone-marrow transplantation. Ann Intern Med. 1977 Dec;87(6):703–706. doi: 10.7326/0003-4819-87-6-703. [DOI] [PubMed] [Google Scholar]
  39. Hale G., Cobbold S., Waldmann H. T cell depletion with CAMPATH-1 in allogeneic bone marrow transplantation. Transplantation. 1988 Apr;45(4):753–759. doi: 10.1097/00007890-198804000-00018. [DOI] [PubMed] [Google Scholar]
  40. Hobbs J. R., Hugh-Jones K., Barrett A. J., Byrom N., Chambers D., Henry K., James D. C., Lucas C. F., Rogers T. R., Benson P. F. Reversal of clinical features of Hurler's disease and biochemical improvement after treatment by bone-marrow transplantation. Lancet. 1981 Oct 3;2(8249):709–712. doi: 10.1016/s0140-6736(81)91046-1. [DOI] [PubMed] [Google Scholar]
  41. Hobbs J. R., Jones K. H., Shaw P. J., Lindsay I., Hancock M. Beneficial effect of pre-transplant splenectomy on displacement bone marrow transplantation for Gaucher's syndrome. Lancet. 1987 May 16;1(8542):1111–1115. doi: 10.1016/s0140-6736(87)91673-4. [DOI] [PubMed] [Google Scholar]
  42. Hoelzer D., Thiel E., Löffler H., Büchner T., Ganser A., Heil G., Koch P., Freund M., Diedrich H., Rühl H. Prognostic factors in a multicenter study for treatment of acute lymphoblastic leukemia in adults. Blood. 1988 Jan;71(1):123–131. [PubMed] [Google Scholar]
  43. Ildstad S. T., Sachs D. H. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature. 1984 Jan 12;307(5947):168–170. doi: 10.1038/307168a0. [DOI] [PubMed] [Google Scholar]
  44. Iriondo A., Garijo J., Baro J., Conde E., Pastor J. M., Sabanés A., Hermosa V., Sainz M. C., Pérez de la Lastra L., Zubizarreta A. Complete recovery of hemopoiesis following bone marrow transplant in a patient with unresponsive congenital hypoplastic anemia (Blackfan-Diamond syndrome). Blood. 1984 Aug;64(2):348–351. [PubMed] [Google Scholar]
  45. Johnson F. L., Thomas E. D., Clark B. S., Chard R. L., Hartmann J. R., Storb R. A comparison of marrow transplantation with chemotherapy for children with acute lymphoblastic leukemia in second or subsequent remission. N Engl J Med. 1981 Oct 8;305(15):846–851. doi: 10.1056/NEJM198110083051502. [DOI] [PubMed] [Google Scholar]
  46. Johnson F. L., Thomas E. D. Treatment of relapsed acute lymphoblastic leukemia in childhood. N Engl J Med. 1984 Jan 26;310(4):263–263. doi: 10.1056/nejm198401263100418. [DOI] [PubMed] [Google Scholar]
  47. Kernan N. A., Flomenberg N., Dupont B., O'Reilly R. J. Graft rejection in recipients of T-cell-depleted HLA-nonidentical marrow transplants for leukemia. Identification of host-derived antidonor allocytotoxic T lymphocytes. Transplantation. 1987 Jun;43(6):842–847. [PubMed] [Google Scholar]
  48. LORENZ E., CONGDON C. C. Modification of lethal irradiation injury in mice by injection of homologous or heterologous bone. J Natl Cancer Inst. 1954 Feb;14(4):955–965. [PubMed] [Google Scholar]
  49. LORENZ E., CONGDON C., UPHOFF D. Modification of acute irradiation injury in mice and guinea-pigs by bone marrow injections. Radiology. 1952 Jun;58(6):863–877. doi: 10.1148/58.6.863. [DOI] [PubMed] [Google Scholar]
  50. Lenarsky C., Weinberg K., Guinan E., Dukes P. P., Barak Y., Ortega J., Siegel S., Williams K., Lazerson J., Weinstein H. Bone marrow transplantation for constitutional pure red cell aplasia. Blood. 1988 Jan;71(1):226–229. [PubMed] [Google Scholar]
  51. Lucarelli G., Galimberti M., Polchi P., Giardini C., Politi P., Baronciani D., Angelucci E., Manenti F., Delfini C., Aureli G. Marrow transplantation in patients with advanced thalassemia. N Engl J Med. 1987 Apr 23;316(17):1050–1055. doi: 10.1056/NEJM198704233161703. [DOI] [PubMed] [Google Scholar]
  52. Martin P. J., Hansen J. A., Buckner C. D., Sanders J. E., Deeg H. J., Stewart P., Appelbaum F. R., Clift R., Fefer A., Witherspoon R. P. Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts. Blood. 1985 Sep;66(3):664–672. [PubMed] [Google Scholar]
  53. McGovern M. M., Ludman M. D., Short M. P., Steinfeld L., Kattan M., Raab E. L., Krivit W., Desnick R. J. Bone marrow transplantation in Maroteaux-Lamy syndrome (MPS type 6): status 40 months after BMT. Birth Defects Orig Artic Ser. 1986;22(1):41–53. [PubMed] [Google Scholar]
  54. Meyers J. D., Flournoy N., Thomas E. D. Nonbacterial pneumonia after allogeneic marrow transplantation: a review of ten years' experience. Rev Infect Dis. 1982 Nov-Dec;4(6):1119–1132. doi: 10.1093/clinids/4.6.1119. [DOI] [PubMed] [Google Scholar]
  55. Mills K. I., MacKenzie E. D., Birnie G. D. The site of the breakpoint within the bcr is a prognostic factor in Philadelphia-positive CML patients. Blood. 1988 Oct;72(4):1237–1241. [PubMed] [Google Scholar]
  56. Mitsuyasu R. T., Champlin R. E., Gale R. P., Ho W. G., Lenarsky C., Winston D., Selch M., Elashoff R., Giorgi J. V., Wells J. Treatment of donor bone marrow with monoclonal anti-T-cell antibody and complement for the prevention of graft-versus-host disease. A prospective, randomized, double-blind trial. Ann Intern Med. 1986 Jul;105(1):20–26. doi: 10.7326/0003-4819-105-1-20. [DOI] [PubMed] [Google Scholar]
  57. Neiman P. E., Reeves W., Ray G., Flournoy N., Lerner K. G., Sale G. E., Thomas E. D. A prospective analysis interstitial pneumonia and opportunistic viral infection among recipients of allogeneic bone marrow grafts. J Infect Dis. 1977 Dec;136(6):754–767. doi: 10.1093/infdis/136.6.754. [DOI] [PubMed] [Google Scholar]
  58. Parkman R., Rappeport J., Geha R., Belli J., Cassady R., Levey R., Nathan D. G., Rosen F. S. Complete correction of the Wiskott-Aldrich syndrome by allogeneic bone-marrow transplantation. N Engl J Med. 1978 Apr 27;298(17):921–927. doi: 10.1056/NEJM197804272981701. [DOI] [PubMed] [Google Scholar]
  59. Parkman R. The application of bone marrow transplantation to the treatment of genetic diseases. Science. 1986 Jun 13;232(4756):1373–1378. doi: 10.1126/science.3520819. [DOI] [PubMed] [Google Scholar]
  60. Radford J. E., Jr, Burns C. P., Jones M. P., Gingrich R. D., Kemp J. D., Edwards R. W., McFadden D. B., Dick F. R., Wen B. C. Adult acute lymphoblastic leukemia: results of the Iowa HOP-L protocol. J Clin Oncol. 1989 Jan;7(1):58–66. doi: 10.1200/JCO.1989.7.1.58. [DOI] [PubMed] [Google Scholar]
  61. Rappeport J. M., Parkman R., Newburger P., Camitta B. M., Chusid M. J. Correction of infantile agranulocytosis (Kostmann's syndrome) by allogeneic bone marrow transplantation. Am J Med. 1980 Apr;68(4):605–609. doi: 10.1016/0002-9343(80)90312-5. [DOI] [PubMed] [Google Scholar]
  62. Reed E. C., Bowden R. A., Dandliker P. S., Lilleby K. E., Meyers J. D. Treatment of cytomegalovirus pneumonia with ganciclovir and intravenous cytomegalovirus immunoglobulin in patients with bone marrow transplants. Ann Intern Med. 1988 Nov 15;109(10):783–788. doi: 10.7326/0003-4819-109-10-783. [DOI] [PubMed] [Google Scholar]
  63. Reisner Y., Kapoor N., Kirkpatrick D., Pollack M. S., Cunningham-Rundles S., Dupont B., Hodes M. Z., Good R. A., O'Reilly R. J. Transplantation for severe combined immunodeficiency with HLA-A,B,D,DR incompatible parental marrow cells fractionated by soybean agglutinin and sheep red blood cells. Blood. 1983 Feb;61(2):341–348. [PubMed] [Google Scholar]
  64. Rivera G. K., Buchanan G., Boyett J. M., Camitta B., Ochs J., Kalwinsky D., Amylon M., Vietti T. J., Crist W. M. Intensive retreatment of childhood acute lymphoblastic leukemia in first bone marrow relapse. A Pediatric Oncology Group Study. N Engl J Med. 1986 Jul 31;315(5):273–278. doi: 10.1056/NEJM198607313150501. [DOI] [PubMed] [Google Scholar]
  65. Sanders J. E., Thomas E. D., Buckner C. D., Flournoy N., Stewart P. S., Clift R. A., Lum L., Bensinger W. I., Storb R., Appelbaum F. R. Marrow transplantation for children in first remission of acute nonlymphoblastic leukemia: an update. Blood. 1985 Aug;66(2):460–462. [PubMed] [Google Scholar]
  66. Santos G. W., Tutschka P. J., Brookmeyer R., Saral R., Beschorner W. E., Bias W. B., Braine H. G., Burns W. H., Elfenbein G. J., Kaizer H. Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulfan and cyclophosphamide. N Engl J Med. 1983 Dec 1;309(22):1347–1353. doi: 10.1056/NEJM198312013092202. [DOI] [PubMed] [Google Scholar]
  67. Schaefer-Rego K., Dudek H., Popenoe D., Arlin Z., Mears J. G., Bank A., Leibowitz D. CML patients in blast crisis have breakpoints localized to a specific region of the BCR. Blood. 1987 Aug;70(2):448–455. [PubMed] [Google Scholar]
  68. Schmidt G. M., Blume K. G., Bross K. J., Spruce W. E., Waldron J. C., Levine R. Parenteral nutrition in bone marrow transplant recipients. Exp Hematol. 1980 Apr;8(4):506–511. [PubMed] [Google Scholar]
  69. Schmidt G. M., Kovacs A., Zaia J. A., Horak D. A., Blume K. G., Nademanee A. P., O'Donnell M. R., Snyder D. S., Forman S. J. Ganciclovir/immunoglobulin combination therapy for the treatment of human cytomegalovirus-associated interstitial pneumonia in bone marrow allograft recipients. Transplantation. 1988 Dec;46(6):905–907. [PubMed] [Google Scholar]
  70. Schmitz N., Gassmann W., Rister M., Johannson W., Suttorp M., Brix F., Holthuis J. J., Heit W., Hertenstein B., Schaub J. Fractionated total body irradiation and high-dose VP 16-213 followed by allogeneic bone marrow transplantation in advanced leukemias. Blood. 1988 Nov;72(5):1567–1573. [PubMed] [Google Scholar]
  71. Schubert M. M., Sullivan K. M., Morton T. H., Izutsu K. T., Peterson D. E., Flournoy N., Truelove E. L., Sale G. E., Buckner C. D., Storb R. Oral manifestations of chronic graft-v-host disease. Arch Intern Med. 1984 Aug;144(8):1591–1595. [PubMed] [Google Scholar]
  72. Shank B., Hopfan S., Kim J. H., Chu F. C., Grossbard E., Kapoor N., Kirkpatrick D., Dinsmore R., Simpson L., Reid A. Hyperfractionated total body irradiation for bone marrow transplantation: I. Early results in leukemia patients. Int J Radiat Oncol Biol Phys. 1981 Aug;7(8):1109–1115. doi: 10.1016/0360-3016(81)90170-x. [DOI] [PubMed] [Google Scholar]
  73. Shulman H. M., Sale G. E., Lerner K. G., Barker E. A., Weiden P. L., Sullivan K., Gallucci B., Thomas E. D., Storb R. Chronic cutaneous graft-versus-host disease in man. Am J Pathol. 1978 Jun;91(3):545–570. [PMC free article] [PubMed] [Google Scholar]
  74. Sieff C. A., Chessells J. M., Levinsky R. J., Pritchard J., Rogers D. W., Casey A., Muller K., Hall C. M. Allogeneic bone-marrow transplantation in infantile malignant osteopetrosis. Lancet. 1983 Feb 26;1(8322):437–441. doi: 10.1016/s0140-6736(83)91438-1. [DOI] [PubMed] [Google Scholar]
  75. Sokal J. E., Baccarani M., Tura S., Fiacchini M., Cervantes F., Rozman C., Gomez G. A., Galton D. A., Canellos G. P., Braun T. J. Prognostic discrimination among younger patients with chronic granulocytic leukemia: relevance to bone marrow transplantation. Blood. 1985 Dec;66(6):1352–1357. [PubMed] [Google Scholar]
  76. Sokal J. E., Gomez G. A. The Philadelphia chromosome and Philadelphia chromosome mosaicism in chronic granulocytic leukemia. J Clin Oncol. 1986 Jan;4(1):104–111. doi: 10.1200/JCO.1986.4.1.104. [DOI] [PubMed] [Google Scholar]
  77. Sorell M., Kapoor N., Kirkpatrick D., Rosen J. F., Chaganti R. S., Lopez C., Dupont B., Pollack M. S., Terrin B. N., Harris M. B. Marrow transplantation for juvenile osteopetrosis. Am J Med. 1981 Jun;70(6):1280–1287. doi: 10.1016/0002-9343(81)90839-1. [DOI] [PubMed] [Google Scholar]
  78. Spangrude G. J., Heimfeld S., Weissman I. L. Purification and characterization of mouse hematopoietic stem cells. Science. 1988 Jul 1;241(4861):58–62. doi: 10.1126/science.2898810. [DOI] [PubMed] [Google Scholar]
  79. Speck B., Gratwohl A., Nissen C., Osterwalder B., Würsch A., Tichelli A., Lori A., Reusser P., Jeannet M., Signer E. Treatment of severe aplastic anemia. Exp Hematol. 1986 Feb;14(2):126–132. [PubMed] [Google Scholar]
  80. Storb R., Deeg H. J., Whitehead J., Appelbaum F., Beatty P., Bensinger W., Buckner C. D., Clift R., Doney K., Farewell V. Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia. N Engl J Med. 1986 Mar 20;314(12):729–735. doi: 10.1056/NEJM198603203141201. [DOI] [PubMed] [Google Scholar]
  81. Storb R., Evans R. S., Thomas E. D., Buckner C. D., Clift R. A., Fefer A., Neiman P., Wright S. E. Paroxysmal nocturnal haemoglobinuria and refractory marrow failure treated by marrow transplantation. Br J Haematol. 1973 Jun;24(6):743–750. doi: 10.1111/j.1365-2141.1973.tb01701.x. [DOI] [PubMed] [Google Scholar]
  82. Storb R., Prentice R. L., Thomas E. D., Appelbaum F. R., Deeg H. J., Doney K., Fefer A., Goodell B. W., Mickelson E., Stewart P. Factors associated with graft rejection after HLA-identical marrow transplantation for aplastic anaemia. Br J Haematol. 1983 Dec;55(4):573–585. doi: 10.1111/j.1365-2141.1983.tb02839.x. [DOI] [PubMed] [Google Scholar]
  83. Sullivan K. M., Shulman H. M., Storb R., Weiden P. L., Witherspoon R. P., McDonald G. B., Schubert M. M., Atkinson K., Thomas E. D. Chronic graft-versus-host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppression. Blood. 1981 Feb;57(2):267–276. [PubMed] [Google Scholar]
  84. Sykes M., Sheard M., Sachs D. H. Effects of T cell depletion in radiation bone marrow chimeras. I. Evidence for a donor cell population which increases allogeneic chimerism but which lacks the potential to produce GVHD. J Immunol. 1988 Oct 1;141(7):2282–2288. [PubMed] [Google Scholar]
  85. Szer J., Deeg H. J., Witherspoon R. P., Fefer A., Buckner C. D., Thomas E. D., Storb R. Long-term survival after marrow transplantation for paroxysmal nocturnal hemoglobinuria with aplastic anemia. Ann Intern Med. 1984 Aug;101(2):193–195. doi: 10.7326/0003-4819-101-2-193. [DOI] [PubMed] [Google Scholar]
  86. Tallman M. S., McGuffin R. W., Higano C. S., Starkebaum G., Collins S. J., Johnston H., Singer J. W., Perry D. J., Kunath A. Bone marrow transplantation in a patient with myelodysplasia associated with diffuse eosinophilic fasciitis. Am J Hematol. 1987 Jan;24(1):93–99. doi: 10.1002/ajh.2830240112. [DOI] [PubMed] [Google Scholar]
  87. Talpaz M., Kantarjian H. M., McCredie K. B., Keating M. J., Trujillo J., Gutterman J. Clinical investigation of human alpha interferon in chronic myelogenous leukemia. Blood. 1987 May;69(5):1280–1288. [PubMed] [Google Scholar]
  88. Thomas E. D., Buckner C. D., Banaji M., Clift R. A., Fefer A., Flournoy N., Goodell B. W., Hickman R. O., Lerner K. G., Neiman P. E. One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation. Blood. 1977 Apr;49(4):511–533. [PubMed] [Google Scholar]
  89. Thomas E. D., Clift R. A., Fefer A., Appelbaum F. R., Beatty P., Bensinger W. I., Buckner C. D., Cheever M. A., Deeg H. J., Doney K. Marrow transplantation for the treatment of chronic myelogenous leukemia. Ann Intern Med. 1986 Feb;104(2):155–163. doi: 10.7326/0003-4819-104-2-155. [DOI] [PubMed] [Google Scholar]
  90. Thomas E. D. Karnofsky Memorial Lecture. Marrow transplantation for malignant diseases. J Clin Oncol. 1983 Sep;1(9):517–531. doi: 10.1200/JCO.1983.1.9.517. [DOI] [PubMed] [Google Scholar]
  91. Thomas E. D., Ramberg R. E., Sale G. E., Sparkes R. S., Golde D. W. Direct evidence for a bone marrow origin of the alveolar macrophage in man. Science. 1976 Jun 4;192(4243):1016–1018. doi: 10.1126/science.775638. [DOI] [PubMed] [Google Scholar]
  92. Thomas E. D., Storb R., Clift R. A., Fefer A., Johnson L., Neiman P. E., Lerner K. G., Glucksberg H., Buckner C. D. Bone-marrow transplantation (second of two parts). N Engl J Med. 1975 Apr 24;292(17):895–902. doi: 10.1056/NEJM197504242921706. [DOI] [PubMed] [Google Scholar]
  93. Thomas E. D., Storb R. Technique for human marrow grafting. Blood. 1970 Oct;36(4):507–515. [PubMed] [Google Scholar]
  94. Tutschka P. J., Copelan E. A., Klein J. P. Bone marrow transplantation for leukemia following a new busulfan and cyclophosphamide regimen. Blood. 1987 Nov;70(5):1382–1388. [PubMed] [Google Scholar]
  95. Weiden P. L., Flournoy N., Sanders J. E., Sullivan K. M., Thomas E. D. Antileukemic effect of graft-versus-host disease contributes to improved survival after allogeneic marrow transplantation. Transplant Proc. 1981 Mar;13(1 Pt 1):248–251. [PubMed] [Google Scholar]
  96. Weiden P. L., Sullivan K. M., Flournoy N., Storb R., Thomas E. D. Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantation. N Engl J Med. 1981 Jun 18;304(25):1529–1533. doi: 10.1056/NEJM198106183042507. [DOI] [PubMed] [Google Scholar]
  97. Weiner R. S., Bortin M. M., Gale R. P., Gluckman E., Kay H. E., Kolb H. J., Hartz A. J., Rimm A. A. Interstitial pneumonitis after bone marrow transplantation. Assessment of risk factors. Ann Intern Med. 1986 Feb;104(2):168–175. doi: 10.7326/0003-4819-104-2-168. [DOI] [PubMed] [Google Scholar]
  98. Weisdorf S. A., Lysne J., Wind D., Haake R. J., Sharp H. L., Goldman A., Schissel K., McGlave P. B., Ramsay N. K., Kersey J. H. Positive effect of prophylactic total parenteral nutrition on long-term outcome of bone marrow transplantation. Transplantation. 1987 Jun;43(6):833–838. [PubMed] [Google Scholar]
  99. Wingard J. R., Chen D. Y., Burns W. H., Fuller D. J., Braine H. G., Yeager A. M., Kaiser H., Burke P. J., Graham M. L., Santos G. W. Cytomegalovirus infection after autologous bone marrow transplantation with comparison to infection after allogeneic bone marrow transplantation. Blood. 1988 May;71(5):1432–1437. [PubMed] [Google Scholar]
  100. Winston D. J., Gale R. P., Meyer D. V., Young L. S. Infectious complications of human bone marrow transplantation. Medicine (Baltimore) 1979 Jan;58(1):1–31. doi: 10.1097/00005792-197901000-00001. [DOI] [PubMed] [Google Scholar]
  101. Wolf J. L., Spruce W. E., Bearman R. M., Forman S. J., Scott E. P., Fahey J. L., Farbstein M. J., Rappaport H., Blume K. G. Reversal of acute ("malignant") myelosclerosis by allogeneic bone marrow transplantation. Blood. 1982 Jan;59(1):191–193. [PubMed] [Google Scholar]
  102. Woodruff J. M., Hansen J. A., Good R. A., Santos G. W., Slavin R. E. The pathology of the graft-versus-host reaction (GVHR) in adults receiving bone marrow transplants. Transplant Proc. 1976 Dec;8(4):675–684. [PubMed] [Google Scholar]
  103. Zander A. R., Keating M., Dicke K., Dixon D., Pierce S., Jagannath S., Peters L., Horwitz L., Cockerill K., Spitzer G. A comparison of marrow transplantation with chemotherapy for adults with acute leukemia of poor prognosis in first complete remission. J Clin Oncol. 1988 Oct;6(10):1548–1557. doi: 10.1200/JCO.1988.6.10.1548. [DOI] [PubMed] [Google Scholar]
  104. van der Meer J. W., Guiot H. F., van den Broek P. J., van Furth R. Infections in bone marrow transplant recipients. Semin Hematol. 1984 Apr;21(2):123–140. [PubMed] [Google Scholar]

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