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. 1997 Jul;41(1):66–69. doi: 10.1136/gut.41.1.66

Measles virus serology in Crohn's disease.

N C Fisher 1, L Yee 1, P Nightingale 1, R McEwan 1, J A Gibson 1
PMCID: PMC1027230  PMID: 9274474

Abstract

BACKGROUND: There is evidence that measles virus infection in early life may predispose to Crohn's disease. AIMS: To examine using serological methods a potential association between measles virus infection in early life and predisposition to Crohn's disease. SUBJECTS: Forty five patients with Crohn's disease and forty five healthy controls were studied prospectively. METHODS: Clinical data were recorded and serum was analysed for measles virus, cytomegalovirus (CMV), adenovirus and herpes simplex virus (HSV) antibody titres by a complement fixation test (CFT), and for measles virus IgM by enzyme linked immunosorbent assay (ELISA). RESULTS: Reciprocal CFT titres for measles virus were lower in patients with Crohn's disease compared with controls (p < 0.05); there was no significant difference in titres for other viruses. None of the subjects studied had a level of measles virus IgM suggestive of acute infection, and there was no significant difference in measles virus IgM levels between patients and controls. The measles virus CFT titres and IgM levels in the patients with Crohn's disease did not correlate with any of the clinical features recorded. CONCLUSION: This study does not provide supportive evidence for a role for measles virus in the aetiology of Crohn's disease.

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Selected References

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  1. Blaser M. J., Miller R. A., Lacher J., Singleton J. W. Patients with active Crohn's disease have elevated serum antibodies to antigens of seven enteric bacterial pathogens. Gastroenterology. 1984 Oct;87(4):888–894. [PubMed] [Google Scholar]
  2. Connolly J. H., Allen I. V., Hurwitz L. J., Millar J. H. Measles-virus antibody and antigen in subacute sclerosing panencephalitis. Lancet. 1967 Mar 11;1(7489):542–544. doi: 10.1016/s0140-6736(67)92117-4. [DOI] [PubMed] [Google Scholar]
  3. Ekbom A., Adami H. O., Helmick C. G., Jonzon A., Zack M. M. Perinatal risk factors for inflammatory bowel disease: a case-control study. Am J Epidemiol. 1990 Dec;132(6):1111–1119. doi: 10.1093/oxfordjournals.aje.a115754. [DOI] [PubMed] [Google Scholar]
  4. Ekbom A., Daszak P., Kraaz W., Wakefield A. J. Crohn's disease after in-utero measles virus exposure. Lancet. 1996 Aug 24;348(9026):515–517. doi: 10.1016/S0140-6736(96)04429-7. [DOI] [PubMed] [Google Scholar]
  5. Ekbom A., Wakefield A. J., Zack M., Adami H. O. Perinatal measles infection and subsequent Crohn's disease. Lancet. 1994 Aug 20;344(8921):508–510. doi: 10.1016/s0140-6736(94)91898-8. [DOI] [PubMed] [Google Scholar]
  6. Harvey R. F., Bradshaw J. M. A simple index of Crohn's-disease activity. Lancet. 1980 Mar 8;1(8167):514–514. doi: 10.1016/s0140-6736(80)92767-1. [DOI] [PubMed] [Google Scholar]
  7. Iizuka M., Nakagomi O., Chiba M., Ueda S., Masamune O. Absence of measles virus in Crohn's disease. Lancet. 1995 Jan 21;345(8943):199–199. doi: 10.1016/s0140-6736(95)90207-4. [DOI] [PubMed] [Google Scholar]
  8. Jabbour J. T., Sever J. L. Serum measles antibody titers in patients with subacute sclerosing panencephalitis, compared with parents and siblings. J Pediatr. 1968 Dec;73(6):905–907. doi: 10.1016/s0022-3476(68)80245-8. [DOI] [PubMed] [Google Scholar]
  9. Kim M., LaPointe J., Liu F. J. Epidemiology of measles immunity in a population of healthcare workers. Infect Control Hosp Epidemiol. 1992 Jul;13(7):399–402. doi: 10.1086/646557. [DOI] [PubMed] [Google Scholar]
  10. Lewin J., Dhillon A. P., Sim R., Mazure G., Pounder R. E., Wakefield A. J. Persistent measles virus infection of the intestine: confirmation by immunogold electron microscopy. Gut. 1995 Apr;36(4):564–569. doi: 10.1136/gut.36.4.564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Poser C. M. Notes on the pathogenesis of subacute sclerosing panencephalitis. J Neurol Sci. 1990 Feb;95(2):219–224. doi: 10.1016/0022-510x(90)90244-h. [DOI] [PubMed] [Google Scholar]
  13. Ramsay M., Cohen B., Brown D. Serum IgM testing is needed in all cases of suspected measles. BMJ. 1996 Jul 27;313(7051):231–231. doi: 10.1136/bmj.313.7051.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Thompson N. P., Montgomery S. M., Pounder R. E., Wakefield A. J. Is measles vaccination a risk factor for inflammatory bowel disease? Lancet. 1995 Apr 29;345(8957):1071–1074. doi: 10.1016/s0140-6736(95)90816-1. [DOI] [PubMed] [Google Scholar]
  15. Thompson N. P., Pounder R. E., Wakefield A. J. Perinatal and childhood risk factors for inflammatory bowel disease: a case-control study. Eur J Gastroenterol Hepatol. 1995 May;7(5):385–390. [PubMed] [Google Scholar]
  16. Touze I., Dubucquoi S., Cortot A., Van Kruiningen H. J., Colombel J. F. IgM-specific measles-virus antibody in families with a high frequency of Crohn's disease. Lancet. 1995 Oct 7;346(8980):967–967. doi: 10.1016/s0140-6736(95)91587-7. [DOI] [PubMed] [Google Scholar]
  17. Wakefield A. J., Pittilo R. M., Sim R., Cosby S. L., Stephenson J. R., Dhillon A. P., Pounder R. E. Evidence of persistent measles virus infection in Crohn's disease. J Med Virol. 1993 Apr;39(4):345–353. doi: 10.1002/jmv.1890390415. [DOI] [PubMed] [Google Scholar]
  18. Wakefield A. J., Sankey E. A., Dhillon A. P., Sawyerr A. M., More L., Sim R., Pittilo R. M., Rowles P. M., Hudson M., Lewis A. A. Granulomatous vasculitis in Crohn's disease. Gastroenterology. 1991 May;100(5 Pt 1):1279–1287. [PubMed] [Google Scholar]
  19. Wisniewski H. M., Brown H. R., Thormar H. Pathogenesis of viral encephalitis: demonstration of viral antigen(s) in the brain endothelium. Acta Neuropathol. 1983;60(1-2):107–112. doi: 10.1007/BF00685354. [DOI] [PubMed] [Google Scholar]

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