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. 1983 Mar;46(3):261–265. doi: 10.1136/jnnp.46.3.261

Progressive leptomeningeal fibrosis: a clinico-pathological case report.

D Chalif, L W Duchen, J Marshall, R Hayward
PMCID: PMC1027334  PMID: 6842233

Abstract

A female patient developed persistent facial pain beginning at age 19 years. Intermittent motor and sensory disturbances referable to one hemisphere began nine years later and by the age of 41 she had developed signs of increased intracranial pressure. Exploratory craniotomy revealed replacement of the leptomeninges by thick, fibrous tissue. The histological appearance was that of a chronic, benign and minimally infiltrative process with a mild, non-specific inflammatory component, underlying cortical ischaemic changes, and white matter oedema. The lesion resembled nodular fasciitis, a soft tissue process. No cause of the reactive fibrosis of the meninges in this case is known.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen P. W. The fibromatoses: a clinicopathologic classification based on 140 cases. Am J Surg Pathol. 1977 Sep;1(3):255–270. [PubMed] [Google Scholar]
  2. Baker A. B., Adams J. M. Primary Fibroblastoma of the Brain: Report of a Case. Am J Pathol. 1937 Jan;13(1):129–138.1. [PMC free article] [PubMed] [Google Scholar]
  3. Brucher J. M., Hizawa K., Wechsler W. Ultrastructure d'un fibrome intracérébral et possibilité de transformation maligne de ce type tumoral. Rev Neurol (Paris) 1970 Dec;123(6):443–445. [PubMed] [Google Scholar]
  4. Carrillo R., Ricoy J. R., Herrero-Vallejo J., Bravo G. Fibrous xanthomas of the brain. Report of two cases. Clin Neurol Neurosurg. 1975;78(1):34–40. doi: 10.1016/s0303-8467(75)80005-9. [DOI] [PubMed] [Google Scholar]
  5. Dolman C. L., Crichton J. U., Jones E. A., Lapointe J. Fibromatosis of dura presenting as infantile spasms. J Neurol Sci. 1981 Jan;49(1):31–39. doi: 10.1016/0022-510x(81)90185-4. [DOI] [PubMed] [Google Scholar]
  6. Friede R. L., Pollak A. Neurosurgical desmoid tumors: presentation of four cases with a review of the differential diagnoses. J Neurosurg. 1979 Jun;50(6):725–732. doi: 10.3171/jns.1979.50.6.0725. [DOI] [PubMed] [Google Scholar]
  7. HUTTER R. V., STEWART F. W., FOOTE F. W., Jr Fasciitis. A report of 70 cases with follow-up proving the benignity of the lesion. Cancer. 1962 Sep-Oct;15:992–1003. doi: 10.1002/1097-0142(196209/10)15:5<992::aid-cncr2820150516>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  8. Hindle W., Posner E., Sweetnam M. T., Tan R. S. Pleural effusion and fibrosis during treatment with methysergide. Br Med J. 1970 Mar 7;1(5696):605–606. doi: 10.1136/bmj.1.5696.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kamisasa A., Kuwabara T., Inaba Y. Intracranial ossifying fibroma. Report of a case. Bull Tokyo Med Dent Univ. 1973 Sep;20(3):209–220. [PubMed] [Google Scholar]
  10. Kepes J. J., Kepes M., Slowik F. Fibrous xanthomas and xanthosarcomas of the meninges and the brain. Acta Neuropathol. 1973 Feb 19;23(3):187–199. doi: 10.1007/BF00687875. [DOI] [PubMed] [Google Scholar]
  11. Koos W. T., Jellinger K., Sunder-Plassmann M. Intracerebral fibroma in an 11-month-old infant. Case report. J Neurosurg. 1971 Jul;35(1):77–81. doi: 10.3171/jns.1971.35.1.0077. [DOI] [PubMed] [Google Scholar]
  12. Lehrer H. Z. Ossifying fibroma of the orbital roof. Its distinction from "blistering" or "intra-osseous" meningioma. Arch Neurol. 1969 May;20(5):536–541. doi: 10.1001/archneur.1969.00480110100010. [DOI] [PubMed] [Google Scholar]
  13. Llena J. F., Chung H. D., Hirano A., Feiring E. H., Zimmerman H. M. Intracerebellar "fibroma". Case report. J Neurosurg. 1975 Jul;43(1):98–101. doi: 10.3171/jns.1975.43.1.0098. [DOI] [PubMed] [Google Scholar]
  14. Malcomson K. G. Ossifying fibroma of the sphenoid. J Laryngol Otol. 1967 Jan;81(1):87–92. doi: 10.1017/s0022215100066810. [DOI] [PubMed] [Google Scholar]
  15. PETTIT V. D., CHAMNESS J. T., ACKERMAN L. V. Fibromatosis and fibrosarcoma following irradiation therapy. Cancer. 1954 Jan;7(1):149–158. doi: 10.1002/1097-0142(195401)7:1<149::aid-cncr2820070116>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  16. PRICE E. B., Jr, SILLIPHANT W. M., SHUMAN R. Nodular fasciitis: a clinicopathologic analysis of 65 cases. Am J Clin Pathol. 1961 Feb;35:122–136. doi: 10.1093/ajcp/35.2.122. [DOI] [PubMed] [Google Scholar]
  17. Quest D. O., Salcman M. Fibromatosis presenting as a cranial mass lesion; case report. J Neurosurg. 1976 Feb;44(2):237–240. doi: 10.3171/jns.1976.44.2.0237. [DOI] [PubMed] [Google Scholar]
  18. Schrantz J. L., Araoz C. A. Radiation induced meningeal fibrosarcoma. Arch Pathol. 1972 Jan;93(1):26–31. [PubMed] [Google Scholar]
  19. Scott M., Peale A. R., Croissant P. D. Intracranial midline anterior fossae ossifying fibroma invading orbits, paranasal sinuses, and right maxillary antrum. Case report. J Neurosurg. 1971 Jun;34(6):827–831. doi: 10.3171/jns.1971.34.6.0827. [DOI] [PubMed] [Google Scholar]
  20. Suzuki S., Ishii M., Ottomo M., Iwabuchi T. Changes in the subarachnoid space after experimental subarachnoid haemorrhage in the dog: scanning electron microscopic observation. Acta Neurochir (Wien) 1977;39(1-2):1–14. doi: 10.1007/BF01405236. [DOI] [PubMed] [Google Scholar]
  21. TENG P., WARDEN M. J., COHN W. L. Congenital generalized fibromatosis (renal and skeletal) with complete spontaneous regression. J Pediatr. 1963 May;62:748–753. doi: 10.1016/s0022-3476(63)80045-1. [DOI] [PubMed] [Google Scholar]

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