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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1983 May;46(5):410–413. doi: 10.1136/jnnp.46.5.410

Tetrahydrobiopterin metabolism in senile dementia of Alzheimer type.

A A Aziz 1, R J Leeming 1, J A Blair 1
PMCID: PMC1027388  PMID: 6152915

Abstract

Tetrahydrobiopterin metabolism was shown to be disturbed in 18 patients with senile dementia of Alzheimer type. This may have a bearing on the pathogenesis of the disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adolfsson R., Gottfries C. G., Roos B. E., Winblad B. Changes in the brain catecholamines in patients with dementia of Alzheimer type. Br J Psychiatry. 1979 Sep;135:216–223. doi: 10.1192/bjp.135.3.216. [DOI] [PubMed] [Google Scholar]
  2. Berger B., Escourolle R., Moyne M. A. Axones catécholaminergiques du cortex cérébral humain. Observation, en histofluorescence, de biopsies cérébrales dont 2 cas de maladie d'Alzheimer. Rev Neurol (Paris) 1976 Mar;132(3):183–194. [PubMed] [Google Scholar]
  3. Bowen D. M., White P., Spillane J. A., Goodhardt M. J., Curzon G., Iwangoff P., Meier-Ruge W., Davison A. N. Accelerated ageing or selective neuronal loss as an important cause of dementia? Lancet. 1979 Jan 6;1(8106):11–14. doi: 10.1016/s0140-6736(79)90454-9. [DOI] [PubMed] [Google Scholar]
  4. Davies P., Maloney A. J. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet. 1976 Dec 25;2(8000):1403–1403. doi: 10.1016/s0140-6736(76)91936-x. [DOI] [PubMed] [Google Scholar]
  5. Davies P. Neurotransmitter-related enzymes in senile dementia of the Alzheimer type. Brain Res. 1979 Aug 3;171(2):319–327. doi: 10.1016/0006-8993(79)90336-6. [DOI] [PubMed] [Google Scholar]
  6. Leeming R. J., Blair J. A., Melikian V., O'Gorman D. J. Biopterin derivatives in human body fluids and tissues. J Clin Pathol. 1976 May;29(5):444–451. doi: 10.1136/jcp.29.5.444. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Leeming R. J., Blair J. A., Rey F. Letter: Biopterin derivatives in atypical phenylketonuria. Lancet. 1976 Jan 10;1(7950):99–100. doi: 10.1016/s0140-6736(76)90204-x. [DOI] [PubMed] [Google Scholar]
  8. Leeming R. J., Blair J. A. The effects of pathological and normal physiological processes on biopterin derivative levels in man. Clin Chim Acta. 1980 Nov 20;108(1):103–111. doi: 10.1016/0009-8981(80)90298-3. [DOI] [PubMed] [Google Scholar]
  9. Mann J. J., Stanley M., Neophytides A., de Leon M. J., Ferris S. H., Gershon S. Central amine metabolism in Alzheimer's disease: in vivo relationship to cognitive deficit. Neurobiol Aging. 1981 Spring;2(1):57–60. doi: 10.1016/0197-4580(81)90060-9. [DOI] [PubMed] [Google Scholar]
  10. Perry E. K., Perry R. H., Blessed G., Tomlinson B. E. Necropsy evidence of central cholinergic deficits in senile dementia. Lancet. 1977 Jan 22;1(8004):189–189. doi: 10.1016/s0140-6736(77)91780-9. [DOI] [PubMed] [Google Scholar]
  11. Rey F., Leeming R. J., Blair J. A., Rey J. Biopterin defect in a normal-appearing child affected by a transient phenylketonuria. Arch Dis Child. 1980 Aug;55(8):637–639. doi: 10.1136/adc.55.8.637. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. White P., Hiley C. R., Goodhardt M. J., Carrasco L. H., Keet J. P., Williams I. E., Bowen D. M. Neocortical cholinergic neurons in elderly people. Lancet. 1977 Mar 26;1(8013):668–671. doi: 10.1016/s0140-6736(77)92114-6. [DOI] [PubMed] [Google Scholar]
  13. Williams A. C., Levine R. A., Chase T. N., Lovenberg W., Calne D. B. CFS hydroxylase cofactor levels in some neurological diseases. J Neurol Neurosurg Psychiatry. 1980 Aug;43(8):735–738. doi: 10.1136/jnnp.43.8.735. [DOI] [PMC free article] [PubMed] [Google Scholar]

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