Skip to main content
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1983 May;46(5):421–425. doi: 10.1136/jnnp.46.5.421

Identical twins with Alzheimer's disease.

C Kilpatrick 1, R Burns 1, P C Blumbergs 1
PMCID: PMC1027390  PMID: 6101177

Abstract

Genetically proven identical twin sisters with Alzheimer's disease are reported. Both sisters at the age of fifty years developed a dementing illness. Their mother and maternal grandmother developed at the same age a similar illness. It is suggested that in some cases of familial Alzheimer's disease the condition is inherited by a single mutant gene.

Full text

PDF
421

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ball M. J., Nuttall K. Neurofibrillary tangles, granulovacuolar degeneration, and neuron loss in Down Syndrome: quantitative comparison with Alzheimer dementia. Ann Neurol. 1980 May;7(5):462–465. doi: 10.1002/ana.410070512. [DOI] [PubMed] [Google Scholar]
  2. Cook R. H., Schneck S. A., Clark D. B. Twins with Alzheimer's disease. Arch Neurol. 1981 May;38(5):300–301. doi: 10.1001/archneur.1981.00510050066011. [DOI] [PubMed] [Google Scholar]
  3. Cook R. H., Schneck S. A., Clark D. B. Twins with Alzheimer's disease. Arch Neurol. 1981 May;38(5):300–301. doi: 10.1001/archneur.1981.00510050066011. [DOI] [PubMed] [Google Scholar]
  4. Cook R. H., Ward B. E., Austin J. H. Studies in aging of the brain: IV. Familial Alzheimer disease: Relation to transmissible dementia, aneuploidy, and microtubular defects. Neurology. 1979 Oct;29(10):1402–1412. doi: 10.1212/wnl.29.10.1402. [DOI] [PubMed] [Google Scholar]
  5. DAVIDSON E. A., ROBERTSON E. E. Alzheimer's disease with acne rosacea in one of identical twins. J Neurol Neurosurg Psychiatry. 1955 Feb;18(1):72–77. doi: 10.1136/jnnp.18.1.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Henschke P. J., Bell D. A., Cape R. D. Alzheimer's disease and HLA. Tissue Antigens. 1978 Aug;12(2):132–135. doi: 10.1111/j.1399-0039.1978.tb01308.x. [DOI] [PubMed] [Google Scholar]
  7. Heston L. L., Mastri A. R., Anderson V. E., White J. Dementia of the Alzheimer type. Clinical genetics, natural history, and associated conditions. Arch Gen Psychiatry. 1981 Oct;38(10):1085–1090. doi: 10.1001/archpsyc.1981.01780350019001. [DOI] [PubMed] [Google Scholar]
  8. Hunter R., Dayan A. D., Wilson J. Alzheimer's disease in one monozygotic twin. J Neurol Neurosurg Psychiatry. 1972 Oct;35(5):707–710. doi: 10.1136/jnnp.35.5.707. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Masters C. L., Gajdusek D. C., Gibbs C. J., Jr The familial occurrence of Creutzfeldt-Jakob disease and Alzheimer's disease. Brain. 1981 Sep;104(3):535–558. doi: 10.1093/brain/104.3.535. [DOI] [PubMed] [Google Scholar]
  10. Olson M. I., Shaw C. M. Presenile dementia and Alzheimer's disease in mongolism. Brain. 1969 Mar;92(1):147–156. doi: 10.1093/brain/92.1.147. [DOI] [PubMed] [Google Scholar]
  11. Snowden P. R., Woodrow J. C., Copeland J. R. HLA antigens in senile dementia and multiple infarct dementia. Age Ageing. 1981 Nov;10(4):259–263. doi: 10.1093/ageing/10.4.259. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES