Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1984 Mar;47(3):250–255. doi: 10.1136/jnnp.47.3.250

Deficient learning and memory in early and middle phases of multiple sclerosis.

I Grant, W I McDonald, M R Trimble, E Smith, R Reed
PMCID: PMC1027722  PMID: 6323636

Abstract

Forty-three patients with multiple sclerosis showed disturbances in short-term memory, learning, and delayed recall which were associated with years of active disease (average was 4.5 years), age, presence of flareup, but not steroid/ACTH treatment. Unrecognised memory loss might be prevalent early in the natural history of multiple sclerosis and deserves neuropsychological assessment.

Full text

PDF
250

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beatty P. A., Gange J. J. Neuropsychological aspects of multiple sclerosis. J Nerv Ment Dis. 1977 Jan;164(1):42–50. doi: 10.1097/00005053-197701000-00008. [DOI] [PubMed] [Google Scholar]
  2. Butters N., Sax D., Montgomery K., Tarlow S. Comparison of the neuropsychological deficits associated with early and advanced Huntington's disease. Arch Neurol. 1978 Sep;35(9):585–589. doi: 10.1001/archneur.1978.00500330033006. [DOI] [PubMed] [Google Scholar]
  3. Goldstein G., Shelly C. H. Neuropsychological diagnosis of multiple sclerosis in a neuropsychiatric setting. J Nerv Ment Dis. 1974 Apr;158(4):280–290. doi: 10.1097/00005053-197404000-00006. [DOI] [PubMed] [Google Scholar]
  4. Ivnik R. J. Neuropsychological stability in multiple sclerosis. J Consult Clin Psychol. 1978 Oct;46(5):913–923. doi: 10.1037//0022-006x.46.5.913. [DOI] [PubMed] [Google Scholar]
  5. Ivnik R. J. Neuropsychological test performance as a function of the duration of MS-related symptomatology. J Clin Psychiatry. 1978 Apr;39(4):304-7, 311-2. [PubMed] [Google Scholar]
  6. Jambor K. L. Cognitive functioning in multiple sclerosis. Br J Psychiatry. 1969 Jul;115(524):765–775. doi: 10.1192/bjp.115.524.765. [DOI] [PubMed] [Google Scholar]
  7. Marsh G. G. Disability and intellectual function in multiple sclerosis patients. J Nerv Ment Dis. 1980 Dec;168(12):758–762. doi: 10.1097/00005053-198012000-00009. [DOI] [PubMed] [Google Scholar]
  8. Matthews C. G., Cleeland C. S., Hopper C. L. Neuropsychological patterns in multiple sclerosis. Dis Nerv Syst. 1970 Mar;31(3):161–170. [PubMed] [Google Scholar]
  9. PARSONS O. A., STEWART K. D., ARENBERG D. Impairment of abstracting ability in multiple sclerosis. J Nerv Ment Dis. 1957 Apr-Jun;125(2):221–225. doi: 10.1097/00005053-195704000-00007. [DOI] [PubMed] [Google Scholar]
  10. PETERSON L. R., PETERSON M. J. Short-term retention of individual verbal items. J Exp Psychol. 1959 Sep;58:193–198. doi: 10.1037/h0049234. [DOI] [PubMed] [Google Scholar]
  11. Peyser J. M., Edwards K. R., Poser C. M., Filskov S. B. Cognitive function in patients with multiple sclerosis. Arch Neurol. 1980 Sep;37(9):577–579. doi: 10.1001/archneur.1980.00500580073013. [DOI] [PubMed] [Google Scholar]
  12. Poser C. M., Paty D. W., Scheinberg L., McDonald W. I., Davis F. A., Ebers G. C., Johnson K. P., Sibley W. A., Silberberg D. H., Tourtellotte W. W. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. doi: 10.1002/ana.410130302. [DOI] [PubMed] [Google Scholar]
  13. ROSS A. T., REITAN R. M. Intellectual and affective functions in multiple sclerosis; a quantitative study. AMA Arch Neurol Psychiatry. 1955 Jun;73(6):663–677. doi: 10.1001/archneurpsyc.1955.02330120067007. [DOI] [PubMed] [Google Scholar]
  14. Reitan R. M., Reed J. C., Dyken M. L. Cognitive, psychomotor, and motor correlates of multiple sclerosis. J Nerv Ment Dis. 1971 Sep;153(3):218–224. doi: 10.1097/00005053-197109000-00006. [DOI] [PubMed] [Google Scholar]
  15. Squire L. R. The neuropsychology of human memory. Annu Rev Neurosci. 1982;5:241–273. doi: 10.1146/annurev.ne.05.030182.001325. [DOI] [PubMed] [Google Scholar]
  16. Staples D., Lincoln N. B. Intellectual impairment in multiple sclerosis and its relation to functional abilities. Rheumatol Rehabil. 1979 Aug;18(3):153–160. doi: 10.1093/rheumatology/18.3.153. [DOI] [PubMed] [Google Scholar]
  17. Surridge D. An investigation into some psychiatric aspects of multiple sclerosis. Br J Psychiatry. 1969 Jul;115(524):749–764. doi: 10.1192/bjp.115.524.749. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES