Abstract
A 45-year (1935-79) retrospective study of essential tremor based on original medical records on residents of Rochester, Minnesota, is presented. The age and sex adjusted incidence for the most recent 15 year period was 23.7 per 100 000 for US white population. The prevalence rate, age and sex adjusted to 1970 US white population on January 1, 1979 was estimated at 305.6 per 100 000. Survival after diagnosis of essential tremor is comparable to age and sex matched population of West North Central United States. Mean age at diagnosis was 58 (range 2-96) years. Age adjusted annual incidence rate was not different in males (18.3/100 000) and females (17.1/100 000). Functional handicap was reported by four (1.5%) of the 266 incidence cases in school, 13 (5%) cases at work and five cases (2%) retired prematurely. Excessive use of alcohol was noted in 16% and 6% were diagnosed as alcoholic. Torticollis was diagnosed in 3% cases and an additional diagnosis of Parkinson's disease after the index date was made in 2% of incidence cases. Subsequent emergence of Parkinsonism was regarded as incidental. Diagnosis of hypertension was made at some time in 30% of incidence cases during the period (mean 37 years) for which the medical records were available. Risk of hypertension after onset of essential tremor in the cases was not different from that in a control group.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aminoff M. J., Dedo H. H., Izdebski K. Clinical aspects of spasmodic dysphonia. J Neurol Neurosurg Psychiatry. 1978 Apr;41(4):361–365. doi: 10.1136/jnnp.41.4.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barbeau A., Pourcher E. New data on the genetics of Parkinson's disease. Can J Neurol Sci. 1982 Feb;9(1):53–60. doi: 10.1017/s031716710004364x. [DOI] [PubMed] [Google Scholar]
- Critchley E. Clinical manifestations of essential tremor. J Neurol Neurosurg Psychiatry. 1972 Jun;35(3):365–372. doi: 10.1136/jnnp.35.3.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DAVIS C. H., Jr, KUNKLE E. C. Benign essential (heredofamilial) tremor. AMA Arch Intern Med. 1951 Jun;87(6):808–816. doi: 10.1001/archinte.1951.03810060035004. [DOI] [PubMed] [Google Scholar]
- Findley L. J., Gresty M. A., Halmagyi G. M. Tremor, the cogwheel phenomenon and clonus in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1981 Jun;44(6):534–546. doi: 10.1136/jnnp.44.6.534. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haerer A. F., Anderson D. W., Schoenberg B. S. Prevalence of essential tremor. Results from the Copiah County study. Arch Neurol. 1982 Dec;39(12):750–751. doi: 10.1001/archneur.1982.00510240012003. [DOI] [PubMed] [Google Scholar]
- Hornabrook R. W., Nagurney J. T. Essential tremor in Papua, New Guinea. Brain. 1976 Dec;99(4):659–672. doi: 10.1093/brain/99.4.659. [DOI] [PubMed] [Google Scholar]
- Jankovic J., Fahn S. Physiologic and pathologic tremors. Diagnosis, mechanism, and management. Ann Intern Med. 1980 Sep;93(3):460–465. doi: 10.7326/0003-4819-93-3-460. [DOI] [PubMed] [Google Scholar]
- Jankovic J., Ford J. Blepharospasm and orofacial-cervical dystonia: clinical and pharmacological findings in 100 patients. Ann Neurol. 1983 Apr;13(4):402–411. doi: 10.1002/ana.410130406. [DOI] [PubMed] [Google Scholar]
- LARSSON T., SJOGREN T. Essential tremor: a clinical and genetic population study. Acta Psychiatr Scand Suppl. 1960;36(144):1–176. [PubMed] [Google Scholar]
- Mantel N. Ranking procedures for arbitrarily restricted observation. Biometrics. 1967 Mar;23(1):65–78. [PubMed] [Google Scholar]
- Murray T. J. Essential tremor. Can Med Assoc J. 1981 Jun 15;124(12):1559-65, 1570. [PMC free article] [PubMed] [Google Scholar]
- Murray T. J. Long-term therapy of essential tremor with propranolol. Can Med Assoc J. 1976 Nov 6;115(9):892–894. [PMC free article] [PubMed] [Google Scholar]
- Murray T. J. Treatment of essential tremor with propranolol. Can Med Assoc J. 1972 Nov 18;107(10):984–986. [PMC free article] [PubMed] [Google Scholar]
- Rajput A. H., Jamieson H., Hirsh S., Quraishi A. Relative efficacy of alcohol and propranolol in action tremor. Can J Neurol Sci. 1975 Feb;2(1):31–35. doi: 10.1017/s0317167100019958. [DOI] [PubMed] [Google Scholar]
- Rautakorpi I., Takala J., Marttila R. J., Sievers K., Rinne U. K. Essential tremor in a Finnish population. Acta Neurol Scand. 1982 Jul;66(1):58–67. doi: 10.1111/j.1600-0404.1982.tb03129.x. [DOI] [PubMed] [Google Scholar]
- Schroeder D., Nasrallah H. A. High alcoholism rate in patients with essential tremor. Am J Psychiatry. 1982 Nov;139(11):1471–1473. doi: 10.1176/ajp.139.11.1471. [DOI] [PubMed] [Google Scholar]
- Sevitt I. A comparison of propranolol and benzhexol in essential tremor. Practitioner. 1974 Jul;213(1273):91–96. [PubMed] [Google Scholar]
- Shahani B. T., Young R. R. Physiological and pharmacological aids in the differential diagnosis of tremor. J Neurol Neurosurg Psychiatry. 1976 Aug;39(8):772–783. doi: 10.1136/jnnp.39.8.772. [DOI] [PMC free article] [PubMed] [Google Scholar]