Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1984 Jul;47(7):715–719. doi: 10.1136/jnnp.47.7.715

Phenytoin-induced increase in growth hormone response to levodopa in adult males.

R D'Alessandro, P Cortelli, R Gallassi, E Ghisoli, N Montanaro, E Zoni, A Baruzzi
PMCID: PMC1027900  PMID: 6431057

Abstract

Growth hormone and prolactin response to levodopa were evaluated before and after long-term phenytoin treatment in five men with previously untreated partial epilepsy. After phenytoin treatment, growth hormone response to levodopa increased. There was a close relationship between growth hormone response to levodopa and plasma phenytoin concentrations. These findings suggest a phenytoin-induced dopaminergic activity at the hypothalamic-pituitary level in adult males.

Full text

PDF
715

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boyd A. E., 3rd, Lebovitz H. E., Pfeiffer J. B. Stimulation of human-growth-hormone secretion by L-dopa. N Engl J Med. 1970 Dec 24;283(26):1425–1429. doi: 10.1056/NEJM197012242832602. [DOI] [PubMed] [Google Scholar]
  2. Elliott P. N., Jenner P., Chadwick D., Reynolds E., Marsden C. D. The effect of diphenylhydantoin on central catecholamine containing neuronal systems. J Pharm Pharmacol. 1977 Jan;29(1):41–43. doi: 10.1111/j.2042-7158.1977.tb11235.x. [DOI] [PubMed] [Google Scholar]
  3. Hadfield M. G. Uptake and binding of catecholamines. Effect of diphenylhydantoin and a new mechanism of action. Arch Neurol. 1972 Jan;26(1):78–84. doi: 10.1001/archneur.1972.00490070096012. [DOI] [PubMed] [Google Scholar]
  4. Imura H., Nakai Y., Yoshimi T. Effect of 5-hydroxytryptophan (5-HTP) on growth hormone and ACTH release in man. J Clin Endocrinol Metab. 1973 Jan;36(1):204–206. doi: 10.1210/jcem-36-1-204. [DOI] [PubMed] [Google Scholar]
  5. Kamberi I. A., Mical R. S., Porter J. C. Effect of anterior pituitary perfusion and intraventricular injection of catecholamines on prolactin release. Endocrinology. 1971 Apr;88(4):1012–1020. doi: 10.1210/endo-88-4-1012. [DOI] [PubMed] [Google Scholar]
  6. Klawans H. L., Jr A pharmacologic analysis of Huntington's chorea. Eur Neurol. 1970;4(3):148–163. doi: 10.1159/000114017. [DOI] [PubMed] [Google Scholar]
  7. Klawans H. L., Jr, Paulson G. W., Ringel S. P., Barbeau A. Use of L-dopa in the detection of presymptomatic Huntington's chorea. N Engl J Med. 1972 Jun 22;286(25):1332–1334. doi: 10.1056/NEJM197206222862503. [DOI] [PubMed] [Google Scholar]
  8. Lühdorf K., Lund M. Phenytoin-induced hyperkinesia. Epilepsia. 1977 Sep;18(3):409–415. doi: 10.1111/j.1528-1157.1977.tb04984.x. [DOI] [PubMed] [Google Scholar]
  9. Martin J. B., Lal S., Tolis G., Friesen H. G. Inhibition by apomorphine of prolactin secretion in patients with elevated serum prolactin. J Clin Endocrinol Metab. 1974 Jul;39(1):180–182. doi: 10.1210/jcem-39-1-180. [DOI] [PubMed] [Google Scholar]
  10. Martin J. B. Neural regulation of growth hormone secretion. N Engl J Med. 1973 Jun 28;288(26):1384–1393. doi: 10.1056/NEJM197306282882606. [DOI] [PubMed] [Google Scholar]
  11. Riva R., Albani F., Baruzzi A. Rapid quantitative determination of underivatized carbamazepine, phenytoin, phenobarbital and p-hydroxyphenobarbital in biological fluids by packed column gas chromatography. J Chromatogr. 1980 Nov 14;221(1):75–84. doi: 10.1016/s0378-4347(00)81009-9. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES