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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1984 Aug;47(8):769–774. doi: 10.1136/jnnp.47.8.769

A double-blind trial of chronic cerebellar stimulation in twelve patients with severe epilepsy.

G D Wright, D L McLellan, J G Brice
PMCID: PMC1027936  PMID: 6381652

Abstract

Twelve patients with severe intractable epilepsy were treated by chronic cerebellar stimulation under double-blind conditions for six months. No reduction in seizure frequency occurred that could be attributed to stimulation, though eleven of the patients considered that the trial had helped them. One patient experienced fewer episodes of incontinence during stimulation. Cerebellar stimulation in its present form cannot be recommended for the treatment of severe intractable epilepsy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cooper I. S., Amin I., Riklan M., Waltz J. M., Poon T. P. Chronic cerebellar stimulation in epilepsy. Clinical and anatomical studies. Arch Neurol. 1976 Aug;33(8):559–570. doi: 10.1001/archneur.1976.00500080037006. [DOI] [PubMed] [Google Scholar]
  2. Cooper I. S. Effect of chronic stimulation of anterior cerebellum on neurological disease. Lancet. 1973 Jan 27;1(7796):206–206. doi: 10.1016/s0140-6736(73)90042-1. [DOI] [PubMed] [Google Scholar]
  3. Larson S. J., Sances A., Jr, Hemmy D. C., Millar E. A., Walsh P. R. Physiological and histological effects of cerebellar stimulation. Appl Neurophysiol. 1977;40(2-4):160–174. doi: 10.1159/000102440. [DOI] [PubMed] [Google Scholar]
  4. Levy L. F., Auchterlonie W. C. Chronic cerebellar stimulation in the treatment of epilepsy. Epilepsia. 1979 Jun;20(3):235–245. doi: 10.1111/j.1528-1157.1979.tb04800.x. [DOI] [PubMed] [Google Scholar]
  5. McLellan D. L., Wright G. D., Renouf F. Calibration of clinical cerebellar and deep brain stimulation systems. J Neurol Neurosurg Psychiatry. 1981 May;44(5):392–396. doi: 10.1136/jnnp.44.5.392. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Upton A. R., Cooper I. S. Some neurophysiological effects of cerebellar stimulation in man. Can J Neurol Sci. 1976 Nov;3(4):237–254. doi: 10.1017/s031716710002535x. [DOI] [PubMed] [Google Scholar]
  7. Van Buren J. M., Wood J. H., Oakley J., Hambrecht F. Preliminary evaluation of cerebellar stimulation by double-blind stimulation and biological criteria in the treatment of epilepsy. J Neurosurg. 1978 Mar;48(3):407–416. doi: 10.3171/jns.1978.48.3.0407. [DOI] [PubMed] [Google Scholar]
  8. Wright G. D., Weller R. O. Biopsy and post-mortem findings in a patient receiving cerebellar stimulation for epilepsy. J Neurol Neurosurg Psychiatry. 1983 Mar;46(3):266–273. doi: 10.1136/jnnp.46.3.266. [DOI] [PMC free article] [PubMed] [Google Scholar]

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