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. 1984 Sep;47(9):912–916. doi: 10.1136/jnnp.47.9.912

Amino acid uptake by dorsal root ganglia from streptozotocin-diabetic rats.

P K Thomas, D W Wright, E Tzebelikos
PMCID: PMC1027990  PMID: 6207270

Abstract

Dorsal root ganglia from streptozotocin-diabetic rats and age- and weight-matched control animals were incubated with 4-amino 3H-butyric acid. A significant reduction in uptake was observed in the diabetic animals. The incorporation of 3H-leucine into protein was also significantly reduced but the results did not allow a conclusion as to whether this was a secondary or an independent effect. These findings are discussed in relation both to the abnormalities known to develop in diabetic rats and to the causation of human diabetic neuropathy.

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Selected References

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