Abstract
A previous study has shown a high incidence of abnormal auditory brainstem responses in alcoholics, particularly when cerebral and/or cerebellar atrophy was present in CT scans. To correlate the electrophysiological findings with definable morphological alterations, quantitative measurements of the brainstem structures in CT scans were made. To determine the relative size of the brainstem, the ratio between the sizes of the brainstem and its cisterns was obtained at the midbrain, upper and lower pons. When compared to the aged-matched control group, the alcoholics as a whole and the alcoholics with abnormal auditory brainstem responses had a decrease in the ratio at all three brainstem levels, but these ratios were not decreased in the alcoholics with the normal auditory brainstem responses. The present data indicate that abnormal brainstem responses in the alcoholics correlated with an increased size of the brainstem cisterns and possible brainstem atrophy.
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- ADAMS R. D., VICTOR M., MANCALL E. L. Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients. AMA Arch Neurol Psychiatry. 1959 Feb;81(2):154–172. [PubMed] [Google Scholar]
- Beagley H. A., Sheldrake J. B. Differences in brainstem response latency with age and sex. Br J Audiol. 1978 Aug;12(3):69–77. doi: 10.3109/03005367809078858. [DOI] [PubMed] [Google Scholar]
- Bergman H., Borg S., Hindmarsh T., Ideström C. M., Mützell S. Computed tomography of the brain and neuropsychological assessment of male alcoholic patients and a random sample from the general male population. Acta Psychiatr Scand Suppl. 1980;286:77–88. doi: 10.1111/j.1600-0447.1980.tb08056.x. [DOI] [PubMed] [Google Scholar]
- Cala L. A., Jones B., Mastaglia F. L., Wiley B. Brain atrophy and intellectual impairment in heavy drinkers--a clinical, psychometric and computerized tomography study. Aust N Z J Med. 1978 Apr;8(2):147–153. doi: 10.1111/j.1445-5994.1978.tb04502.x. [DOI] [PubMed] [Google Scholar]
- Chiappa K. H., Harrison J. L., Brooks E. B., Young R. R. Brainstem auditory evoked responses in 200 patients with multiple sclerosis. Ann Neurol. 1980 Feb;7(2):135–143. doi: 10.1002/ana.410070208. [DOI] [PubMed] [Google Scholar]
- Chu N. S., Squires K. C., Starr A. Auditory brain stem responses in chronic alcoholic patients. Electroencephalogr Clin Neurophysiol. 1982 Oct;54(4):418–425. doi: 10.1016/0013-4694(82)90205-x. [DOI] [PubMed] [Google Scholar]
- Epstein P. S., Pisani V. D., Fawcett J. A. Alcoholism and cerebral atrophy. Alcohol Clin Exp Res. 1977 Jan;1(1):61–65. doi: 10.1111/j.1530-0277.1977.tb05769.x. [DOI] [PubMed] [Google Scholar]
- Gilroy J., Lynn G. E. Computerized tomography and auditory-evoked potentials. Use in the diagnosis of olivopontocerebellar degeneration. Arch Neurol. 1978 Mar;35(3):143–147. doi: 10.1001/archneur.1978.00500270025006. [DOI] [PubMed] [Google Scholar]
- Hammond E. J., Wilder B. J. Evoked potentials in olivopontocerebellar atrophy. Arch Neurol. 1983 Jun;40(6):366–369. doi: 10.1001/archneur.1983.04050060066012. [DOI] [PubMed] [Google Scholar]
- Harper C. G., Blumbergs P. C. Brain weights in alcoholics. J Neurol Neurosurg Psychiatry. 1982 Sep;45(9):838–840. doi: 10.1136/jnnp.45.9.838. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haubek A., Lee K. Computed tomography in alcoholic cerebellar atrophy. Neuroradiology. 1979 Aug 15;18(2):77–79. doi: 10.1007/BF00344826. [DOI] [PubMed] [Google Scholar]
- Kleinschmidt-DeMasters B. K., Norenberg M. D. Cerebellar degeneration in the rat following rapid correction of hyponatremia. Ann Neurol. 1981 Dec;10(6):561–565. doi: 10.1002/ana.410100612. [DOI] [PubMed] [Google Scholar]
- Kleinschmidt-DeMasters B. K., Norenberg M. D. Neuropathologic observations in electrolyte-induced myelinolysis in the rat. J Neuropathol Exp Neurol. 1982 Jan;41(1):67–80. doi: 10.1097/00005072-198201000-00007. [DOI] [PubMed] [Google Scholar]
- LYNCH M. J. Brain lesions in chronic alcoholism. Arch Pathol. 1960 Mar;69:342–353. [PubMed] [Google Scholar]
- Lusins J., Zimberg S., Smokler H., Gurley K. Alcoholism and cerebral atrophy: a study of 50 patients with CT scan and psychologic testing. Alcohol Clin Exp Res. 1980 Oct;4(4):406–411. doi: 10.1111/j.1530-0277.1980.tb04840.x. [DOI] [PubMed] [Google Scholar]
- Norenberg M. D., Leslie K. O., Robertson A. S. Association between rise in serum sodium and central pontine myelinolysis. Ann Neurol. 1982 Feb;11(2):128–135. doi: 10.1002/ana.410110204. [DOI] [PubMed] [Google Scholar]
- Ron M. A., Acker W., Shaw G. K., Lishman W. A. Computerized tomography of the brain in chronic alcoholism: a Survey and follow-up study. Brain. 1982 Sep;105(Pt 3):497–514. doi: 10.1093/brain/105.3.497. [DOI] [PubMed] [Google Scholar]
- Rosenhamer H. J., Lindström B., Lundborg T. On the use of click-evoked electric brainstem responses in audiological diagnosis. II. The influence of sex and age upon the normal response. Scand Audiol. 1980;9(2):93–100. doi: 10.3109/01050398009076342. [DOI] [PubMed] [Google Scholar]
- Rosenhamer H. J., Silfverskiöld B. P. Slow tremor and delayed brainstem auditory evoked responses in alcoholics. Arch Neurol. 1980 May;37(5):293–296. doi: 10.1001/archneur.1980.00500540071010. [DOI] [PubMed] [Google Scholar]
- Rowe M. J., 3rd Normal variability of the brain-stem auditory evoked response in young and old adult subjects. Electroencephalogr Clin Neurophysiol. 1978 Apr;44(4):459–470. doi: 10.1016/0013-4694(78)90030-5. [DOI] [PubMed] [Google Scholar]
- Starr A., Achor J. Auditory brain stem responses in neurological disease. Arch Neurol. 1975 Nov;32(11):761–768. doi: 10.1001/archneur.1975.00490530083009. [DOI] [PubMed] [Google Scholar]
- Stockard J. E., Stockard J. J., Westmoreland B. F., Corfits J. L. Brainstem auditory-evoked responses. Normal variation as a function of stimulus and subject characteristics. Arch Neurol. 1979 Dec;36(13):823–831. doi: 10.1001/archneur.1979.00500490037006. [DOI] [PubMed] [Google Scholar]
- Torvik A., Lindboe C. F., Rogde S. Brain lesions in alcoholics. A neuropathological study with clinical correlations. J Neurol Sci. 1982 Nov;56(2-3):233–248. doi: 10.1016/0022-510x(82)90145-9. [DOI] [PubMed] [Google Scholar]