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. 1985 May;48(5):459–468. doi: 10.1136/jnnp.48.5.459

Antiepileptic and antiamnesic effect of carbamazepine in experimental limbic epilepsy.

C A Hawkins, J Mellanby, J Brown
PMCID: PMC1028334  PMID: 4039750

Abstract

Carbamazepine (20 mg/kg, 40 mg/kg or 60 mg/kg) given three times a day, has been demonstrated to have a significant anti-epileptic effect in rats with chronic limbic epilepsy induced by injecting tetanus toxin bilaterally into their hippocampi. This effect involved a reduction in the maximum number of fits occurring on one day, and with the highest dose, a significant reduction in the total number of fits. In a pilot experiment in which continuous EEG records were obtained throughout the syndrome, it appeared that the effect of carbamazepine was to reduce the proportion of EEG seizure discharges which lead to overt motor fits. With the higher drug dose plasma levels of carbamazepine were maintained around 2 micrograms/ml. This experimental epilepsy produces enduring deficits in the rats' memories for a light-discrimination task in a Y-maze learned before induction of epilepsy (8 weeks after initial learning). If the rats are dosed with carbamazepine during their epilepsy this memory deficit is abolished.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. George G., Mellanby J. A further study on the effect of physostigmine on memory in rats. Brain Res. 1974 Nov 29;81(1):133–144. doi: 10.1016/0006-8993(74)90483-1. [DOI] [PubMed] [Google Scholar]
  2. George G., Mellanby J. Memory deficits in an experimental hippocampal epileptiform syndrome in rats. Exp Neurol. 1982 Mar;75(3):678–689. doi: 10.1016/0014-4886(82)90034-6. [DOI] [PubMed] [Google Scholar]
  3. Kutt H., Solomon G., Wasterlain C., Peterson H., Louis S., Carruthers R. Carbamazepine in difficult to control epileptic out-patients. Acta Neurol Scand Suppl. 1975;60:27–32. doi: 10.1111/j.1600-0404.1975.tb01384.x. [DOI] [PubMed] [Google Scholar]
  4. Mellanby J., George G., Robinson A., Thompson P. Epileptiform syndrome in rats produced by injecting tetanus toxin into the hippocampus. J Neurol Neurosurg Psychiatry. 1977 Apr;40(4):404–414. doi: 10.1136/jnnp.40.4.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Mellanby J., Green J. How does tetanus toxin act? Neuroscience. 1981;6(3):281–300. doi: 10.1016/0306-4522(81)90123-8. [DOI] [PubMed] [Google Scholar]
  6. Mellanby J., Mellanby H., Pope D., Van Heyningen W. E. Ganglioside as a prophylactic agent in experimental tetanus in mice. J Gen Microbiol. 1968 Dec;54(2):161–168. doi: 10.1099/00221287-54-2-161. [DOI] [PubMed] [Google Scholar]
  7. Mellanby J., Renshaw M., Cracknell H., Rands G., Thompson P. Long-term impairment of learning ability in rats after an experimental hippocampal epileptiform syndrome. Exp Neurol. 1982 Mar;75(3):690–699. doi: 10.1016/0014-4886(82)90035-8. [DOI] [PubMed] [Google Scholar]
  8. Mellanby J., Strawbridge P., Collingridge G. I., George G., Rands G., Stroud C., Thompson P. Behavioural correlates of an experimental hippocampal epileptiform syndrome in rats. J Neurol Neurosurg Psychiatry. 1981 Dec;44(12):1084–1093. doi: 10.1136/jnnp.44.12.1084. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pryse-Phillips W. E., Jeavons P. M. Effect of carbamazepine (Tegretol) on the electroencephalograph and ward behaviour of patients with chronic epilepsy. Epilepsia. 1970 Sep;11(3):263–273. doi: 10.1111/j.1528-1157.1970.tb03890.x. [DOI] [PubMed] [Google Scholar]
  10. Simonsen N., Olsen P. Z., Kühl V., Lund M., Wendelboe J. A comparative controlled study between carbamazepine and diphenylhydantoin in psychomotor epilepsy. Epilepsia. 1976 Jun;17(2):169–176. doi: 10.1111/j.1528-1157.1976.tb03394.x. [DOI] [PubMed] [Google Scholar]
  11. Trimble M. R., Thompson P. J. Memory, anticonvulsant drugs and seizures. Acta Neurol Scand Suppl. 1981;89:31–41. doi: 10.1111/j.1600-0404.1981.tb02360.x. [DOI] [PubMed] [Google Scholar]
  12. Troupin A., Ojemann L. M., Halpern L., Dodrill C., Wilkus R., Friel P., Feigl P. Carbamazepine--a double-blind comparison with phenytoin. Neurology. 1977 Jun;27(6):511–519. doi: 10.1212/wnl.27.6.511. [DOI] [PubMed] [Google Scholar]
  13. Wilkus R. J., Dodrill C. B., Troupin A. S. Carbamazepine and the electroencephalogram of epileptics: a double blind study in comparison to phenytoin. Epilepsia. 1978 Jun;19(3):283–291. doi: 10.1111/j.1528-1157.1978.tb04491.x. [DOI] [PubMed] [Google Scholar]

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