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. 1985 Aug;48(8):736–742. doi: 10.1136/jnnp.48.8.736

A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease.

A Little, R Levy, P Chuaqui-Kidd, D Hand
PMCID: PMC1028443  PMID: 3897460

Abstract

The first long-term double-blind placebo controlled trial of high dose lecithin in senile dementia of the Alzheimer type is reported. Fifty one subjects were given 20-25 g/day of purified soya lecithin (containing 90% phosphatidyl plus lysophosphatidyl choline) for six months and followed up for at least a further six months. Plasma choline levels were monitored throughout the treatment period. There were no differences between the placebo group and the lecithin group but there was an improvement in a subgroup of relatively poor compliers. These were older and had intermediate levels of plasma choline. It is suggested that the effects of lecithin are complex but that there may be a "therapeutic window" for the effects of lecithin in the condition and that this may be more evident in older patients.

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Selected References

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