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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1985 Aug;48(8):814–818. doi: 10.1136/jnnp.48.8.814

Cerebellar calcification and lead.

M D Benson, J Price
PMCID: PMC1028454  PMID: 4031933

Abstract

In elderly subjects who were brought up in a known high lead environment in Queensland, Australia, childhood residence and occupational status provide circumstantial evidence of a relationship between excessive lead intake and cerebellar calcification as seen on computed tomography. This supports experimental and neuropathological studies demonstrating an association between exposure to lead and perivascular cerebellar calcification.

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Selected References

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  1. Ahlgren L., Haeger-Aronsen B., Mattsson S., Schütz A. In-vivo determination of lead in the skeleton after occupational exposure to lead. Br J Ind Med. 1980 May;37(2):109–113. doi: 10.1136/oem.37.2.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ahlgren L., Mattsson S. An X-ray fluorescence technique for in vivo determination of lead concentration in a bone matrix. Phys Med Biol. 1979 Jan;24(1):136–145. doi: 10.1088/0031-9155/24/1/011. [DOI] [PubMed] [Google Scholar]
  3. Goldstein G. W., Asbury A. K., Diamond I. Pathogenesis of lead encephalopathy. Uptake of lead and reaction of brain capillaries. Arch Neurol. 1974 Dec;31(6):382–389. doi: 10.1001/archneur.1974.00490420048005. [DOI] [PubMed] [Google Scholar]
  4. Goldstein G. W. Lead encephalopathy: the significance of lead inhibition of calcium uptake by brain mitochondria. Brain Res. 1977 Nov 4;136(1):185–188. doi: 10.1016/0006-8993(77)90145-7. [DOI] [PubMed] [Google Scholar]
  5. Graham J., Jayasinghe L., Baddeley H. Cerebellar calcification. Diagn Imaging. 1981;50(2):99–106. [PubMed] [Google Scholar]
  6. HENDERSON D. A. The aetiology of chronic nephritis in Queensland. Med J Aust. 1958 Mar 22;45(12):377–386. doi: 10.5694/j.1326-5377.1958.tb86396.x. [DOI] [PubMed] [Google Scholar]
  7. McLEAN R., CALHOUN J. A., AUB J. C. Migration of inorganic salts in bone as measured by radioactive lead and by alizarin. AMA Arch Ind Hyg Occup Med. 1954 Feb;9(2):113–121. [PubMed] [Google Scholar]
  8. Pentschew A., Garro F. Lead encephalo-myelopathy of the suckling rat and its implications on the porphyrinopathic nervous diseases. With special reference to the permeability disorders of the nervous system's capillaries. Acta Neuropathol. 1966 Jun 1;6(3):266–278. doi: 10.1007/BF00687857. [DOI] [PubMed] [Google Scholar]
  9. Price J., Baddeley H., Kenardy J. A., Thomas B. J., Thomas B. W. In vivo X-ray fluorescence estimation of bone lead concentrations in Queensland adults. Br J Radiol. 1984 Jan;57(673):29–33. doi: 10.1259/0007-1285-57-673-29. [DOI] [PubMed] [Google Scholar]
  10. Rabinowitz M. B., Wetherill G. W., Kopple J. D. Lead metabolism in the normal human: stable isotope studies. Science. 1973 Nov 16;182(4113):725–727. doi: 10.1126/science.182.4113.725. [DOI] [PubMed] [Google Scholar]
  11. Saal J. R., Coombe I. F., Thomas B. W., Tonge J. I., Burry A. F. Cerebellar calcification--ultrastructure and histochemistry. Pathology. 1978 Oct;10(4):351–363. doi: 10.3109/00313027809063524. [DOI] [PubMed] [Google Scholar]
  12. Sayre J. W., Charney E., Vostal J., Pless I. B. House and hand dust as a potential source of childhood lead exposure. Am J Dis Child. 1974 Feb;127(2):167–170. doi: 10.1001/archpedi.1974.02110210017002. [DOI] [PubMed] [Google Scholar]
  13. Silbergeld E. K., Wolinsky J. S., Goldstein G. W. Electron probe microanalysis of isolated brain capillaries poisoned with lead. Brain Res. 1980 May 12;189(2):369–376. doi: 10.1016/0006-8993(80)90097-9. [DOI] [PubMed] [Google Scholar]
  14. Thomas J. A., Dallenbach F. D., Thomas M. The distribution of radioactive lead (210Pb) in the cerebellum of developing rats. J Pathol. 1973 Jan;109(1):45–50. doi: 10.1002/path.1711090106. [DOI] [PubMed] [Google Scholar]
  15. Tompsett S. L. The distribution of lead in human bones. Biochem J. 1936 Mar;30(3):345–346. doi: 10.1042/bj0300345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Tonge J. I., Burry A. F., Saal J. R. Cerebellar calcification: a possible marker of lead poisoning. Pathology. 1977 Oct;9(4):289–300. doi: 10.3109/00313027709094449. [DOI] [PubMed] [Google Scholar]

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