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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1985 Oct;48(10):1010–1014. doi: 10.1136/jnnp.48.10.1010

Complex partial seizures: EEG foci and response to carbamazepine and sodium valproate.

A K Gupta, P M Jeavons
PMCID: PMC1028540  PMID: 3932599

Abstract

The EEG and clinical records were reviewed of 85 subjects who had been treated for complex partial seizures with carbamazepine alone or with a combination of carbamazepine and sodium valproate. There was a correlation between the site of the EEG abnormality and the therapeutic response to anticonvulsant therapy. Subjects who had a left sided temporal lobe EEG abnormality responded better to carbamazepine alone, while those who had an abnormality on the right responded to a combination of carbamazepine and sodium valproate.

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Selected References

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  1. Bruni J., Albright P. Valproic acid therapy for complex partial seizures. Its efficacy and toxic effects. Arch Neurol. 1983 Mar;40(3):135–137. doi: 10.1001/archneur.1983.04050030029004. [DOI] [PubMed] [Google Scholar]
  2. Bruni J., Wilder B. J., Bauman A. W., Willmore L. J. Clinical efficacy and long-term effects of valproic acid therapy on spike-and-wave discharges. Neurology. 1980 Jan;30(1):42–46. doi: 10.1212/wnl.30.1.42. [DOI] [PubMed] [Google Scholar]
  3. Cereghino J. J., Brock J. T., Van Meter J. C., Penry J. K., Smith L. D., White B. G. Carbamazepine for epilepsy. A controlled prospective evaluation. Neurology. 1974 May;24(5):401–410. doi: 10.1212/wnl.24.5.401. [DOI] [PubMed] [Google Scholar]
  4. Coulter D. L., Wu H., Allen R. J. Valproic acid therapy in childhood epilepsy. JAMA. 1980 Aug 22;244(8):785–788. [PubMed] [Google Scholar]
  5. Covanis A., Gupta A. K., Jeavons P. M. Sodium valproate: monotherapy and polytherapy. Epilepsia. 1982 Dec;23(6):693–720. doi: 10.1111/j.1528-1157.1982.tb05085.x. [DOI] [PubMed] [Google Scholar]
  6. Gainotti G. Emotional behavior and hemispheric side of the lesion. Cortex. 1972 Mar;8(1):41–55. doi: 10.1016/s0010-9452(72)80026-1. [DOI] [PubMed] [Google Scholar]
  7. HUGHES J. R., SCHLAGENHAUFFRE Electro-clinical correlation in temporal lobe epilepsy with emphasis on inter-areal analysis of the temporal lobe. Electroencephalogr Clin Neurophysiol. 1961 Jun;13:333–339. [PubMed] [Google Scholar]
  8. Haigh D., Forsythe W. I. The treatment of childhood epilepsy with sodium valproate. Dev Med Child Neurol. 1975 Dec;17(6):743–748. doi: 10.1111/j.1469-8749.1975.tb04698.x. [DOI] [PubMed] [Google Scholar]
  9. Jeavons P. M., Clark J. E. Sodium valproate in treatment of epilepsy. Br Med J. 1974 Jun 15;2(5919):584–586. doi: 10.1136/bmj.2.5919.584. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Levine D. N., Finklestein S. Delayed psychosis after right temporoparietal stroke or trauma: relation to epilepsy. Neurology. 1982 Mar;32(3):267–273. doi: 10.1212/wnl.32.3.267. [DOI] [PubMed] [Google Scholar]
  11. Livingston S., Pauli L. L., Pruce I., Kramer I. I. Valproic acid in epilepsy. JAMA. 1979 May 4;241(18):1892–1892. [PubMed] [Google Scholar]
  12. Mikkelsen B., Berggreen P., Joensen P., Kristensen O., Køhler O., Mikkelsen B. O. Clonazepam (Rivotril) and carbamazepine (Tegretol) in psychomotor epilepsy: a randomized multicenter trial. Epilepsia. 1981 Aug;22(4):415–420. doi: 10.1111/j.1528-1157.1981.tb06152.x. [DOI] [PubMed] [Google Scholar]
  13. Milner B. Disorders of learning and memory after temporal lobe lesions in man. Clin Neurosurg. 1972;19:421–446. doi: 10.1093/neurosurgery/19.cn_suppl_1.421. [DOI] [PubMed] [Google Scholar]
  14. PENFIELD W., PEROT P. THE BRAIN'S RECORD OF AUDITORY AND VISUAL EXPERIENCE. A FINAL SUMMARY AND DISCUSSION. Brain. 1963 Dec;86:595–696. doi: 10.1093/brain/86.4.595. [DOI] [PubMed] [Google Scholar]
  15. Pinder R. M., Brogden R. N., Speight T. M., Avery G. S. Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy. Drugs. 1977 Feb;13(2):81–123. doi: 10.2165/00003495-197713020-00001. [DOI] [PubMed] [Google Scholar]
  16. Roberts J. K., Robertson M. M., Trimble M. R. The lateralising significance of hypergraphia in temporal lobe epilepsy. J Neurol Neurosurg Psychiatry. 1982 Feb;45(2):131–138. doi: 10.1136/jnnp.45.2.131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Rodin E. A., Rim C. S., Rennick P. M. The effects of carbamazepine on patients with psychomotor epilepsy: results of a double-blind study. Epilepsia. 1974 Dec;15(4):547–561. doi: 10.1111/j.1528-1157.1974.tb04028.x. [DOI] [PubMed] [Google Scholar]
  18. Rémillard G. M., Andermann F., Gloor P., Olivier A., Martin J. B. Water-drinking as ictal behavior in complex partial seizures. Neurology. 1981 Feb;31(2):117–124. doi: 10.1212/wnl.31.2.117. [DOI] [PubMed] [Google Scholar]
  19. Shakir R. A., Johnson R. H., Lambie D. G., Melville I. D., Nanda R. N. Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. Epilepsia. 1981 Feb;22(1):27–33. doi: 10.1111/j.1528-1157.1981.tb04330.x. [DOI] [PubMed] [Google Scholar]
  20. Sherwin I. Psychosis associated with epilepsy: significance of the laterality of the epileptogenic lesion. J Neurol Neurosurg Psychiatry. 1981 Jan;44(1):83–85. doi: 10.1136/jnnp.44.1.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Shukla G. D., Katiyar B. C. Psychiatric disorders in temporal lobe epilepsy: the laterality effect. Br J Psychiatry. 1980 Aug;137:181–182. doi: 10.1192/bjp.137.2.181. [DOI] [PubMed] [Google Scholar]
  22. Simon D., Penry J. K. Sodium di-N-propylacetate (DPA) in the treatment of epilepsy. A review. Epilepsia. 1975 Nov;16(4):549–573. doi: 10.1111/j.1528-1157.1975.tb04738.x. [DOI] [PubMed] [Google Scholar]
  23. Strandjord R. E., Johannessen S. I. Single-drug therapy with carbamazepine in patients with epilepsy: serum levels and clinical effect. Epilepsia. 1980 Dec;21(6):655–652. doi: 10.1111/j.1528-1157.1980.tb04319.x. [DOI] [PubMed] [Google Scholar]
  24. VAN BUREN J. M., AJMONE-MARSAN C. A correlation of autonomic and EEG components in temporal lobe epilepsy. Arch Neurol. 1960 Dec;3:683–703. doi: 10.1001/archneur.1960.00450060071009. [DOI] [PubMed] [Google Scholar]
  25. VAN BUREN J. M. The abdominal aura. A study of abdominal sensations occurring in epilepsy and produced by depth stimulation. Electroencephalogr Clin Neurophysiol. 1963 Feb;15:1–19. doi: 10.1016/0013-4694(63)90035-x. [DOI] [PubMed] [Google Scholar]

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