Skip to main content
PMC home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1985 Oct;48(10):1025–1030. doi: 10.1136/jnnp.48.10.1025

Autonomic neuropathy in acute intermittent porphyria.

A C Laiwah, G J Macphee, P Boyle, M R Moore, A Goldberg
PMCID: PMC1028543  PMID: 4056804

Abstract

Autonomic function was assessed in subjects with acute intermittent porphyria and age- and sex-matched controls using five different bedside tests of cardiovascular reflexes. During the acute attack both parasympathetic and sympathetic tests were impaired, but subsequently improved during remission. Early parasympathetic dysfunction was also detected during remission and in latent asymptomatic acute intermittent porphyria.

Full text

PDF
1025

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERLIN L., COTTON R. Gastro-intestinal manifestations of porphyria. Am J Dig Dis. 1950 Apr;17(4):110–114. doi: 10.1007/BF03004917. [DOI] [PubMed] [Google Scholar]
  2. Becker D. M., Kramer S., Viljoen J. D. Delta-aminolevulinic acid uptake by rabbit brain cerebral cortex. J Neurochem. 1974 Nov;23(5):1019–1023. doi: 10.1111/j.1471-4159.1974.tb10754.x. [DOI] [PubMed] [Google Scholar]
  3. Bennett T., Farquhar I. K., Hosking D. J., Hampton J. R. Assessment of methods for estimating autonomic nervous control of the heart in patients with diabetes mellitus. Diabetes. 1978 Dec;27(12):1167–1174. doi: 10.2337/diab.27.12.1167. [DOI] [PubMed] [Google Scholar]
  4. Brennan M. J., Cantrill R. C., Kramer S. Effect of delta-aminolaevulinic acid on GABA receptor binding in synaptic plasma membranes. Int J Biochem. 1980;12(5-6):833–835. doi: 10.1016/0020-711x(80)90172-x. [DOI] [PubMed] [Google Scholar]
  5. Caird F. I., Andrews G. R., Kennedy R. D. Effect of posture on blood pressure in the elderly. Br Heart J. 1973 May;35(5):527–530. doi: 10.1136/hrt.35.5.527. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cutler M. G., Moore M. R., Dick J. M. Effects of delta-aminolaevulinic acid on contractile activity of rabbit duodenum. Eur J Pharmacol. 1980 Jun 27;64(4):221–230. doi: 10.1016/0014-2999(80)90229-0. [DOI] [PubMed] [Google Scholar]
  7. Ewing D. J., Campbell I. W., Clarke B. F. Assessment of cardiovascular effects in diabetic autonomic neuropathy and prognostic implications. Ann Intern Med. 1980 Feb;92(2 Pt 2):308–311. doi: 10.7326/0003-4819-92-2-308. [DOI] [PubMed] [Google Scholar]
  8. Ewing D. J., Campbell I. W., Clarke B. F. The natural history of diabetic autonomic neuropathy. Q J Med. 1980 Winter;49(193):95–108. [PubMed] [Google Scholar]
  9. Ewing D. J. Cardiovascular reflexes and autonomic neuropathy. Clin Sci Mol Med. 1978 Oct;55(4):321–327. doi: 10.1042/cs0550321. [DOI] [PubMed] [Google Scholar]
  10. Ewing D. J., Hume L., Campbell I. W., Murray A., Neilson J. M., Clarke B. F. Autonomic mechanisms in the initial heart rate response to standing. J Appl Physiol Respir Environ Exerc Physiol. 1980 Nov;49(5):809–814. doi: 10.1152/jappl.1980.49.5.809. [DOI] [PubMed] [Google Scholar]
  11. GIBSON J. B., GOLDBERG A. The neuropathology of acute porphyria. J Pathol Bacteriol. 1956 Apr;71(2):495–509. doi: 10.1002/path.1700710222. [DOI] [PubMed] [Google Scholar]
  12. Granick S., Sassa S., Granick J. L., Levere R. D., Kappas A. Assays for porphyrins, delta-aminolevulinic-acid dehydratase, and porphyrinogen synthetase in microliter samples of whole blood: applications to metabolic defects involving the heme pathway. Proc Natl Acad Sci U S A. 1972 Sep;69(9):2381–2385. doi: 10.1073/pnas.69.9.2381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Gupta G. L., Saksena H. C., Gupta B. D. Cardiac dysautonomia in acute intermittent porphyria. Indian J Med Res. 1983 Aug;78:253–256. [PubMed] [Google Scholar]
  14. Hellman J. B., Stacy R. W. Variation of respiratory sinus arrhythmia with age. J Appl Physiol. 1976 Nov;41(5 Pt 1):734–738. doi: 10.1152/jappl.1976.41.5.734. [DOI] [PubMed] [Google Scholar]
  15. Hilsted J., Jensen S. B. A simple test for autonomic neuropathy in juvenile diabetics. Acta Med Scand. 1979;205(5):385–387. doi: 10.1111/j.0954-6820.1979.tb06069.x. [DOI] [PubMed] [Google Scholar]
  16. KEZDI P. Neurogenic hypertension in man in porphyria: transient hypertension and tachycardia caused by disruption of the carotid sinus; review of buffer nerve mechanism. AMA Arch Intern Med. 1954 Jul;94(1):122–130. doi: 10.1001/archinte.1954.00250010128010. [DOI] [PubMed] [Google Scholar]
  17. Laiwah A. C., Goldberg A., Moore M. R. Pathogenesis and treatment of acute intermittent porphyria: discussion paper. J R Soc Med. 1983 May;76(5):386–392. doi: 10.1177/014107688307600512. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Loots J. M., Becker D. M., Meyer B. J., Goldstuck N., Kramer S. The effect of porphyrin precursors on monosynaptic reflex activity in the isolated hemisected frog spinal cord. J Neural Transm. 1975;36(1):71–81. doi: 10.1007/BF01243439. [DOI] [PubMed] [Google Scholar]
  19. MAUZERALL D., GRANICK S. The occurrence and determination of delta-amino-levulinic acid and porphobilinogen in urine. J Biol Chem. 1956 Mar;219(1):435–446. [PubMed] [Google Scholar]
  20. Mackay J. D., Page M. M., Cambridge J., Watkins P. J. Diabetic autonomic neuropathy. The diagnostic value of heart rate monitoring. Diabetologia. 1980 Jun;18(6):471–478. doi: 10.1007/BF00261703. [DOI] [PubMed] [Google Scholar]
  21. McColl K. E., Moore M. R., Thompson G. G., Goldberg A. Screening for latent acute intermittent porphyria: the value of measuring both leucocyte delta-aminolaevulinic acid synthase and erythrocyte uroporphyrinogen-1-synthase activities. J Med Genet. 1982 Aug;19(4):271–276. doi: 10.1136/jmg.19.4.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Moore M. R., Thompson G. G., Goldberg A., Ippen H., Seubert A., Seubert S. The biosynthesis of haem in congenital (erythropoietic) porphyria. Int J Biochem. 1978;9(12):933–938. doi: 10.1016/0020-711x(78)90073-3. [DOI] [PubMed] [Google Scholar]
  23. Mustajoki P., Seppălăinen A. M. Neuropathy in latent hereditary hepatic porphyria. Br Med J. 1975 May 10;2(5966):310–312. doi: 10.1136/bmj.2.5966.310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Ridley A., Hierons R., Cavanagh J. B. Tachycardia and the neuropathy of porphyria. Lancet. 1968 Sep 28;2(7570):708–710. doi: 10.1016/s0140-6736(68)90751-4. [DOI] [PubMed] [Google Scholar]
  25. Sorensen A. W., With T. K. Persistent pareses after porphyric attacks. S Afr Med J. 1971 Sep 25;:101–103. [PubMed] [Google Scholar]
  26. Stein J. A., Tschudy D. P. Acute intermittent porphyria. A clinical and biochemical study of 46 patients. Medicine (Baltimore) 1970 Jan;49(1):1–16. [PubMed] [Google Scholar]
  27. Strand L. J., Meyer U. A., Felsher B. F., Redeker A. G., Marver H. S. Decreased red cell uroporphyrinogen I synthetase activity in intermittent acute porphyria. J Clin Invest. 1972 Oct;51(10):2530–2536. doi: 10.1172/JCI107068. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES