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. 1985 Oct;48(10):1062–1064. doi: 10.1136/jnnp.48.10.1062

Suppressor T cell changes in active multiple sclerosis: analysis with three different monoclonal antibodies.

A J Thompson, J Brazil, E A Martin, M Hutchinson, C A Whelan, C Feighery
PMCID: PMC1028550  PMID: 2932538

Abstract

This study demonstrates a significant reduction in the number of both total T cells and suppressor T cells identified by monoclonal antibodies in multiple sclerosis patients in acute relapse but not in those in remission. The reduction in the number of suppressor T cells was shown by all three monoclonal antibodies used but was most clearly demonstrated using Leu 2a rather than either OKT 8 or OKT 5. These findings suggest that the choice of monoclonal antibody used in a study of suppressor T cell numbers will influence the results and may help explain the lack of agreement in previous studies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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