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. 1985 Nov;48(11):1073–1077. doi: 10.1136/jnnp.48.11.1073

The comparative efficacy of antiepileptic drugs for partial and tonic-clonic seizures.

D Chadwick, D M Turnbull
PMCID: PMC1028563  PMID: 3935754

Abstract

Studies of the efficacy of anticonvulsant drugs are difficult to undertake and historically have been of poor quality. Randomised comparisons of drugs are few in number, and have failed to detect significant differences between drugs. This is surprising in view of the strong feelings that many clinicians have about the relative efficacy of the drugs they use. A review of the literature emphasises the need for further studies in this field.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Annegers J. F., Hauser W. A., Elveback L. R. Remission of seizures and relapse in patients with epilepsy. Epilepsia. 1979 Dec;20(6):729–737. doi: 10.1111/j.1528-1157.1979.tb04857.x. [DOI] [PubMed] [Google Scholar]
  2. Cereghino J. J., Brock J. T., Van Meter J. C., Penry J. K., Smith L. D., White B. G. Carbamazepine for epilepsy. A controlled prospective evaluation. Neurology. 1974 May;24(5):401–410. doi: 10.1212/wnl.24.5.401. [DOI] [PubMed] [Google Scholar]
  3. GRUBER C. M., Jr, BROCK J. T., DYKEN M. Comparison of the effectiveness of phenobarital, mephobarbital, primidone, diphenylhydantoin, ethotoin, metharbital, and methylphenylethylhydantoin in motor seizures. Clin Pharmacol Ther. 1962 Jan-Feb;3:23–28. doi: 10.1002/cpt19623123. [DOI] [PubMed] [Google Scholar]
  4. Gibberd F. B., Park D. M., Scott G., Gawel M. J., Fry D. E., Page N. G., Engler C., English J. R., Rose F. C. A comparison of phenytoin and pheneturide in patients with epilepsy: a double-blind cross-over trial. J Neurol Neurosurg Psychiatry. 1982 Dec;45(12):1113–1118. doi: 10.1136/jnnp.45.12.1113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gram L., Bentsen K. D., Parnas J., Flachs H. Controlled trials in epilepsy: a review. Epilepsia. 1982 Oct;23(5):491–519. doi: 10.1111/j.1528-1157.1982.tb05437.x. [DOI] [PubMed] [Google Scholar]
  6. Green J. R., Troupin A. S., Halperm L. M., Friel P., Kanarek P. Sulthiame: evaluation as an anticonvulsant. Epilepsia. 1974 Sep;15(3):329–349. doi: 10.1111/j.1528-1157.1974.tb04012.x. [DOI] [PubMed] [Google Scholar]
  7. Houghton G. W., Richens A. Phenytoin intoxication induced by sulthiame in epileptic patients. J Neurol Neurosurg Psychiatry. 1974 Mar;37(3):275–281. doi: 10.1136/jnnp.37.3.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kosteljanetz M., Christiansen J., Dam A. M., Hansen B. S., Lyon B. B., Pedersen H., Dam M. Carbamazepine vs phenytoin. A controlled clinical trial in focal motor and generalized epilepsy. Arch Neurol. 1979 Jan;36(1):22–24. doi: 10.1001/archneur.1979.00500370052010. [DOI] [PubMed] [Google Scholar]
  9. Loiseau P., Cohadon S., Jogeix M., Legroux M., Dartigues J. F. Efficacité du valproate de sodium dans les épilepsies partielles. Etude croisée valproate-carbamazépiné. Rev Neurol (Paris) 1984;140(6-7):434–437. [PubMed] [Google Scholar]
  10. Marjerrison G., Jedlicki S. M., Keogh R. P., Hrychuk W., Poulakakis G. M. Carbamazepine: behavioral, anticonvulsant and EEG effects in chronically-hospitalized epileptics. Dis Nerv Syst. 1968 Feb;29(2):133–136. [PubMed] [Google Scholar]
  11. Mikkelsen B., Berggreen P., Joensen P., Kristensen O., Køhler O., Mikkelsen B. O. Clonazepam (Rivotril) and carbamazepine (Tegretol) in psychomotor epilepsy: a randomized multicenter trial. Epilepsia. 1981 Aug;22(4):415–420. doi: 10.1111/j.1528-1157.1981.tb06152.x. [DOI] [PubMed] [Google Scholar]
  12. Milichap J. G., Aymat F. Controlled evaluation of primidone and diphenyllhydantoin sodium. Comparative anticonvulsant efficacy and toxicity in children. JAMA. 1968 May 20;204(8):738–739. doi: 10.1001/jama.203.8.738. [DOI] [PubMed] [Google Scholar]
  13. RUSKIN D. B. Comparative results in seizure control using phenobarbital, dilantin, and mesantoin. Am J Psychiatry. 1950 Dec;107(6):415–421. doi: 10.1176/ajp.107.6.415. [DOI] [PubMed] [Google Scholar]
  14. Rajotte P., Jilek W., Jilek L., Perales A., Giard N., Bordeleau J. M., Tétreault L. Propriétés antiépileptiques et psychotropes de la carbamazépine (Tégrétol) Union Med Can. 1967 Oct;96(10):1200–1206. [PubMed] [Google Scholar]
  15. Ramsay R. E., Wilder B. J., Berger J. R., Bruni J. A double-blind study comparing carbamazepine with phenytoin as initial seizure therapy in adults. Neurology. 1983 Jul;33(7):904–910. doi: 10.1212/wnl.33.7.904. [DOI] [PubMed] [Google Scholar]
  16. Reynolds E. H. Chronic antiepileptic toxicity: a review. Epilepsia. 1975 Jun;16(2):319–352. doi: 10.1111/j.1528-1157.1975.tb06062.x. [DOI] [PubMed] [Google Scholar]
  17. Rodin E. A., Rim C. S., Kitano H., Lewis R., Rennick P. M. A comparison of the effectiveness of primidone versus carbamazepine in epileptic outpatients. J Nerv Ment Dis. 1976 Jul;163(1):41–46. doi: 10.1097/00005053-197607000-00006. [DOI] [PubMed] [Google Scholar]
  18. Schmidt D. Reduction of two-drug therapy in intractable epilepsy. Epilepsia. 1983 Jun;24(3):368–376. doi: 10.1111/j.1528-1157.1983.tb04900.x. [DOI] [PubMed] [Google Scholar]
  19. Schmidt D. Two antiepileptic drugs for intractable epilepsy with complex-partial seizures. J Neurol Neurosurg Psychiatry. 1982 Dec;45(12):1119–1124. doi: 10.1136/jnnp.45.12.1119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Shakir R. A., Johnson R. H., Lambie D. G., Melville I. D., Nanda R. N. Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. Epilepsia. 1981 Feb;22(1):27–33. doi: 10.1111/j.1528-1157.1981.tb04330.x. [DOI] [PubMed] [Google Scholar]
  21. Shorvon S. D., Reynolds E. H. Early prognosis of epilepsy. Br Med J (Clin Res Ed) 1982 Dec 11;285(6356):1699–1701. doi: 10.1136/bmj.285.6356.1699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Shorvon S. D., Reynolds E. H. Unnecessary polypharmacy for epilepsy. Br Med J. 1977 Jun 25;1(6077):1635–1637. doi: 10.1136/bmj.1.6077.1635. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Simonsen N., Olsen P. Z., Kühl V., Lund M., Wendelboe J. A comparative controlled study between carbamazepine and diphenylhydantoin in psychomotor epilepsy. Epilepsia. 1976 Jun;17(2):169–176. doi: 10.1111/j.1528-1157.1976.tb03394.x. [DOI] [PubMed] [Google Scholar]
  24. Troupin A., Ojemann L. M., Halpern L., Dodrill C., Wilkus R., Friel P., Feigl P. Carbamazepine--a double-blind comparison with phenytoin. Neurology. 1977 Jun;27(6):511–519. doi: 10.1212/wnl.27.6.511. [DOI] [PubMed] [Google Scholar]
  25. Turnbull D. M., Howel D., Rawlins M. D., Chadwick D. W. Which drug for the adult epileptic patient: phenytoin or valproate? Br Med J (Clin Res Ed) 1985 Mar 16;290(6471):815–819. doi: 10.1136/bmj.290.6471.815. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. White P. T., Plott D., Norton J. Relative anticonvulsant potency of primidone; a double blind comparison. Arch Neurol. 1966 Jan;14(1):31–35. doi: 10.1001/archneur.1966.00470070035004. [DOI] [PubMed] [Google Scholar]
  27. Wilder B. J., Ramsay R. E., Murphy J. V., Karas B. J., Marquardt K., Hammond E. J. Comparison of valproic acid and phenytoin in newly diagnosed tonic-clonic seizures. Neurology. 1983 Nov;33(11):1474–1476. doi: 10.1212/wnl.33.11.1474. [DOI] [PubMed] [Google Scholar]
  28. Wilensky A. J., Ojemann L. M., Temkin N. R., Troupin A. S., Dodrill C. B. Clorazepate and phenobarbital as antiepileptic drugs: a double-blind study. Neurology. 1981 Oct;31(10):1271–1276. doi: 10.1212/wnl.31.10.1271. [DOI] [PubMed] [Google Scholar]

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