Abstract
Brain stem auditory evoked responses (BAERs) were performed on 25 alcoholic patients with Wernicke-Korsakoff syndrome, 56 alcoholic patients without Wernicke-Korsakoff syndrome, 24 of whom had cerebellar ataxia, and 37 control subjects. Abnormal BAERs were found in 48% of patients with Wernicke-Korsakoff syndrome, in 25% of alcoholic patients without Wernicke-Korsakoff syndrome but with cerebellar ataxia, and in 13% of alcoholic patients without Wernicke-Korsakoff syndrome or ataxia. The mean value of the I-V interval was prolonged in all patient groups. There were more patients with prolonged I-V and I-III intervals in the Wernicke-Korsakoff syndrome group than in the group without the syndrome. The I-III interval was prolonged in 32% of those with Wernicke-Korsakoff syndrome but in only 6% of alcoholics without the syndrome. These abnormalities improved following thiamine treatment and abstinence from alcohol. The presence of prolonged I-III interval in an alcoholic should raise the possibility of Wernicke's encephalopathy.
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Selected References
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- Begleiter H., Porjesz B., Chou C. L. Auditory brainstem potentials in chronic alcoholics. Science. 1981 Mar 6;211(4486):1064–1066. doi: 10.1126/science.7466379. [DOI] [PubMed] [Google Scholar]
- Chiappa K. H., Ropper A. H. Evoked potentials in clinical medicine (first of two parts). N Engl J Med. 1982 May 13;306(19):1140–1150. doi: 10.1056/NEJM198205133061904. [DOI] [PubMed] [Google Scholar]
- Chu N. S., Squires K. C., Starr A. Auditory brain stem responses in chronic alcoholic patients. Electroencephalogr Clin Neurophysiol. 1982 Oct;54(4):418–425. doi: 10.1016/0013-4694(82)90205-x. [DOI] [PubMed] [Google Scholar]
- Church M. W., Williams H. L. Dose- and time-dependent effects of ethanol on brain stem auditory evoked responses in young adult males. Electroencephalogr Clin Neurophysiol. 1982 Aug;54(2):161–174. doi: 10.1016/0013-4694(82)90158-4. [DOI] [PubMed] [Google Scholar]
- Harper C. The incidence of Wernicke's encephalopathy in Australia--a neuropathological study of 131 cases. J Neurol Neurosurg Psychiatry. 1983 Jul;46(7):593–598. doi: 10.1136/jnnp.46.7.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harper C. Wernicke's encephalopathy: a more common disease than realised. A neuropathological study of 51 cases. J Neurol Neurosurg Psychiatry. 1979 Mar;42(3):226–231. doi: 10.1136/jnnp.42.3.226. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jewett D. L., Romano M. N., Williston J. S. Human auditory evoked potentials: possible brain stem components detected on the scalp. Science. 1970 Mar 13;167(3924):1517–1518. doi: 10.1126/science.167.3924.1517. [DOI] [PubMed] [Google Scholar]
- LYNCH M. J. Brain lesions in chronic alcoholism. Arch Pathol. 1960 Mar;69:342–353. [PubMed] [Google Scholar]
- Rosenhamer H. J., Lindström B., Lundborg T. On the use of click-evoked electric brainstem responses in audiological diagnosis. III. Latencies in cochlear hearing loss. Scand Audiol. 1981;10(1):3–11. doi: 10.3109/01050398109076156. [DOI] [PubMed] [Google Scholar]
- Rosenhamer H. J., Silfverskiöld B. P. Slow tremor and delayed brainstem auditory evoked responses in alcoholics. Arch Neurol. 1980 May;37(5):293–296. doi: 10.1001/archneur.1980.00500540071010. [DOI] [PubMed] [Google Scholar]
- Starr A., Achor J. Auditory brain stem responses in neurological disease. Arch Neurol. 1975 Nov;32(11):761–768. doi: 10.1001/archneur.1975.00490530083009. [DOI] [PubMed] [Google Scholar]
- Stockard J. J., Rossiter V. S. Clinical and pathologic correlates of brain stem auditory response abnormalities. Neurology. 1977 Apr;27(4):316–325. doi: 10.1212/wnl.27.4.316. [DOI] [PubMed] [Google Scholar]
- Torvik A., Lindboe C. F., Rogde S. Brain lesions in alcoholics. A neuropathological study with clinical correlations. J Neurol Sci. 1982 Nov;56(2-3):233–248. doi: 10.1016/0022-510x(82)90145-9. [DOI] [PubMed] [Google Scholar]
- Victor M., Laureno R. Neurologic complications of alcohol abuse: epidemiologic aspects. Adv Neurol. 1978;19:603–617. [PubMed] [Google Scholar]
