Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1986 Mar;49(3):258–264. doi: 10.1136/jnnp.49.3.258

Relation of clinical, serological, morphological, and electrophysiological findings in galactocerebroside-induced experimental allergic neuritis.

G Stoll, G Schwendemann, K Heininger, W Köhne, H P Hartung, R Seitz, K V Toyka
PMCID: PMC1028724  PMID: 3958739

Abstract

Rabbits were immunised repeatedly with bovine brain galactocerebroside. Almost all animals developed overt polyradiculoneuropathy. Circulating IgG antibodies to galactocerebroside in the serum and deposits of IgG in the spinal roots were detectable weeks before definite clinical, morphological, and electrophysiological alterations occurred. The levels of IgG antibody titres to galactocerebroside did not correlate with the severity of the clinical disease and of nerve conduction slowing. Remyelination and a virtually complete recovery of nerve dysfunction occurred although circulating antibodies to galactocerebroside were still present.

Full text

PDF
258

Images in this article

261Image
on p.261
261Image
on p.261
261Image
on p.261
262Image
on p.262

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown W. F., Feasby T. E. Conduction block and denervation in Guillain-Barré polyneuropathy. Brain. 1984 Mar;107(Pt 1):219–239. doi: 10.1093/brain/107.1.219. [DOI] [PubMed] [Google Scholar]
  2. CRAGG B. G., THOMAS P. K. CHANGES IN NERVE CONDUCTION IN EXPERIMENTAL ALLERGIC NEURITIS. J Neurol Neurosurg Psychiatry. 1964 Apr;27:106–115. doi: 10.1136/jnnp.27.2.106. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dorfman S. H., Fry J. M., Silberberg D. H., Grose C., Manning M. C. Cerebroside antibody titers in antisera capable of myelination inhibition and demyelination. Brain Res. 1978 May 26;147(2):410–415. doi: 10.1016/0006-8993(78)90854-5. [DOI] [PubMed] [Google Scholar]
  4. Fry J. M., Lisak R. P., Manning M. C., Silberberg D. H. Serological techniques for detection of antibody to galactocerebroside. J Immunol Methods. 1976;11(2):185–193. doi: 10.1016/0022-1759(76)90146-0. [DOI] [PubMed] [Google Scholar]
  5. Heininger K., Liebert U. G., Toyka K. V., Haneveld F. T., Schwendemann G., Kolb-Bachofen V., Ross H. G., Cleveland S., Besinger U. A., Gibbels E. Chronic inflammatory polyneuropathy. Reduction of nerve conduction velocities in monkeys by systemic passive transfer of immunoglobulin G. J Neurol Sci. 1984 Oct;66(1):1–14. doi: 10.1016/0022-510x(84)90136-9. [DOI] [PubMed] [Google Scholar]
  6. Lafontaine S., Rasminsky M., Saida T., Sumner A. J. Conduction block in rat myelinated fibres following acute exposure to anti-galactocerebroside serum. J Physiol. 1982 Feb;323:287–306. doi: 10.1113/jphysiol.1982.sp014073. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MCDONALD W. I. THE EFFECTS OF EXPERIMENTAL DEMYELINATION ON CONDUCTION IN PERIPHERAL NERVE: A HISTOLOGICAL AND ELECTROPHYSIOLOGICAL STUDY. II. ELECTROPHYSIOLOGICAL OBSERVATIONS. Brain. 1963 Sep;86:501–524. doi: 10.1093/brain/86.3.501. [DOI] [PubMed] [Google Scholar]
  8. Saida K., Saida T., Brown M. J., Silberberg D. H. In vivo demyelination induced by intraneural injection of anti-galactocerebroside serum: a morphologic study. Am J Pathol. 1979 Apr;95(1):99–116. [PMC free article] [PubMed] [Google Scholar]
  9. Saida T., Saida K., Dorfman S. H., Silberberg D. H., Sumner A. J., Manning M. C., Lisak R. P., Brown M. J. Experimental allergic neuritis induced by sensitization with galactocerebroside. Science. 1979 Jun 8;204(4397):1103–1106. doi: 10.1126/science.451555. [DOI] [PubMed] [Google Scholar]
  10. Saida T., Saida K., Silberberg D. H., Brown M. J. Experimental allergic neuritis induced by galactocerebroside. Ann Neurol. 1981;9 (Suppl):87–101. doi: 10.1002/ana.410090714. [DOI] [PubMed] [Google Scholar]
  11. Server A. C., Lefkowith J., Braine H., McKhann G. M. Treatment of chronic relapsing inflammatory polyradiculoneuropathy by plasma exchange. Ann Neurol. 1979 Sep;6(3):258–261. doi: 10.1002/ana.410060313. [DOI] [PubMed] [Google Scholar]
  12. Smith K. J., Hall S. M. Nerve conduction during peripheral demyelination and remyelination. J Neurol Sci. 1980 Nov;48(2):201–219. doi: 10.1016/0022-510x(80)90201-4. [DOI] [PubMed] [Google Scholar]
  13. Sumner A. J., Saida K., Saida T., Silberberg D. H., Asbury A. K. Acute conduction block associated with experimental antiserum-mediated demyelination of peripheral nerve. Ann Neurol. 1982 May;11(5):469–477. doi: 10.1002/ana.410110506. [DOI] [PubMed] [Google Scholar]
  14. Tuck R. R., Antony J. H., McLeod J. G. F-wave in experimental allergic neuritis. J Neurol Sci. 1982 Nov;56(2-3):173–184. doi: 10.1016/0022-510x(82)90140-x. [DOI] [PubMed] [Google Scholar]
  15. Winter J., Mirsky R., Kadlubowski M. Immunocytochemical study of the appearance of P2 in developing rat peripheral nerve: comparison with other myelin components. J Neurocytol. 1982 Jun;11(3):351–362. doi: 10.1007/BF01257982. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES