Skip to main content
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1986 Apr;49(4):400–404. doi: 10.1136/jnnp.49.4.400

Exposure times for colour discrimination in the parafoveal field: a new procedure to detect subtle visual dysfunction in multiple sclerosis patients.

R Menabue, P Nichelli, S Bellei
PMCID: PMC1028765  PMID: 3701349

Abstract

A new procedure to test colour discrimination in the parafoveal field is described. This method was used on 25 healthy controls and 25 subjects having a definite clinical or laboratory-supported diagnosis of multiple sclerosis, with or without a previous history of optic neuritis. The test proved to be sensitive in detecting visual dysfunction even in some patients in whom the standard technique of pattern-reversal evoked potential recordings yielded a normal result.

Full text

PDF
400

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asselman P., Chadwick D. W., Marsden D. C. Visual evoked responses in the diagnosis and management of patients suspected of multiple sclerosis. Brain. 1975 Jun;98(2):261–282. doi: 10.1093/brain/98.2.261. [DOI] [PubMed] [Google Scholar]
  2. Bodis-Wollner I., Hendley C. D., Mylin L. H., Thornton J. Visual evoked potentials and the visuogram in multiple sclerosis. Ann Neurol. 1979 Jan;5(1):40–47. doi: 10.1002/ana.410050107. [DOI] [PubMed] [Google Scholar]
  3. Chain F., Mallecourt J., Leblanc M., Lhermitte F. Apport de l'enregistrement des potentiels évoqués visuels au diagnostic de la sclérose en plaques. Rev Neurol (Paris) 1977 Feb;133(2):81–88. [PubMed] [Google Scholar]
  4. Daley M. L., Swank R. L., Ellison C. M. Flicker fusion thresholds in multiple sclerosis. A functional measure of neurological damage. Arch Neurol. 1979 May;36(5):292–295. doi: 10.1001/archneur.1979.00500410070010. [DOI] [PubMed] [Google Scholar]
  5. Enoch J. M., Campos E. C., Greer M., Trobe J. Measurement of visual resolution at high luminance levels in patients with possible demyelinating disease. Int Ophthalmol. 1979 Feb;1(2):99–104. doi: 10.1007/BF00154196. [DOI] [PubMed] [Google Scholar]
  6. GARTNER S. Optic neuropathy in multiple sclerosis; optic neuritis. AMA Arch Ophthalmol. 1953 Dec;50(6):718–726. doi: 10.1001/archopht.1953.00920030729007. [DOI] [PubMed] [Google Scholar]
  7. Galvin R. J., Heron J. R., Regan D. Subclinical optic neuropathy in multiple sclerosis. Arch Neurol. 1977 Nov;34(11):666–670. doi: 10.1001/archneur.1977.00500230036005. [DOI] [PubMed] [Google Scholar]
  8. Galvin R. J., Regan D., Heron J. R. Impaired temporal resolution of vision after acute retrobulbar neuritis. Brain. 1976 Jun;99(2):255–268. doi: 10.1093/brain/99.2.255. [DOI] [PubMed] [Google Scholar]
  9. Griffin J. F., Wray S. H. Acquired color vision defects in retrobulbar neuritis. Am J Ophthalmol. 1978 Aug;86(2):193–201. doi: 10.1016/s0002-9394(14)76811-4. [DOI] [PubMed] [Google Scholar]
  10. Halliday A. M., McDonald W. I., Mushin J. Delayed visual evoked response in optic neuritis. Lancet. 1972 May 6;1(7758):982–985. doi: 10.1016/s0140-6736(72)91155-5. [DOI] [PubMed] [Google Scholar]
  11. Heron J. R., Regan D., Milner B. A. Delay in visual perception in unilateral optic atrophy after retrobulbar neuritis. Brain. 1974 Mar;97(1):69–78. doi: 10.1093/brain/97.1.69. [DOI] [PubMed] [Google Scholar]
  12. Heron J. R., Regan D., Milner B. A. Delay in visual perception in unilateral optic atrophy after retrobulbar neuritis. Brain. 1974 Mar;97(1):69–78. doi: 10.1093/brain/97.1.69. [DOI] [PubMed] [Google Scholar]
  13. Kjaer M. Brain stem auditory and visual evoked potentials in multiple sclerosis. Acta Neurol Scand. 1980 Jul;62(1):14–19. doi: 10.1111/j.1600-0404.1980.tb02999.x. [DOI] [PubMed] [Google Scholar]
  14. Kupersmith M. J., Nelson J. I., Seiple W. H., Carr R. E., Weiss P. A. The 20/20 eye in multiple sclerosis. Neurology. 1983 Aug;33(8):1015–1020. doi: 10.1212/wnl.33.8.1015. [DOI] [PubMed] [Google Scholar]
  15. McDonald W. I., Halliday A. M. Diagnosis and classification of multiple sclerosis. Br Med Bull. 1977 Jan;33(1):4–9. [PubMed] [Google Scholar]
  16. Poser C. M., Paty D. W., Scheinberg L., McDonald W. I., Davis F. A., Ebers G. C., Johnson K. P., Sibley W. A., Silberberg D. H., Tourtellotte W. W. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. doi: 10.1002/ana.410130302. [DOI] [PubMed] [Google Scholar]
  17. Regan D., Milner B. A., Heron J. R. Delayed visual perception and delayed visual evoked potentials in the spinal form of multiple sclerosis and in retrobulbar neuritis. Brain. 1976 Mar;99(1):43–66. doi: 10.1093/brain/99.1.43. [DOI] [PubMed] [Google Scholar]
  18. Regan D., Murray T. J., Silver R. Effect of body temperature on visual evoked potential delay and visual perception in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1977 Nov;40(11):1083–1091. doi: 10.1136/jnnp.40.11.1083. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rushton D. Use of the Pulfrich pendulum for detecting abnormal delay in the visual pathway in multiple sclerosis. Brain. 1975 Jun;98(2):283–296. doi: 10.1093/brain/98.2.283. [DOI] [PubMed] [Google Scholar]
  20. STEINMETZ R. D., KEARNS T. P. H-R-R pseudo-isochromatic plates; as a diagnostic aid in retrobulbar neuritis of multiple sclerosis. Am J Ophthalmol. 1956 May;41(5):833–837. [PubMed] [Google Scholar]
  21. Shahrokhi F., Chiappa K. H., Young R. R. Pattern shift visual evoked responses. Two hundred patients with optic neuritis and/or multiple sclerosis. Arch Neurol. 1978 Feb;35(2):65–71. doi: 10.1001/archneur.1978.00500260003001. [DOI] [PubMed] [Google Scholar]
  22. Trojaborg W., Böttcher J., Saxtrup O. Evoked potentials and immunoglobulin abnormalities in multiple sclerosis. Neurology. 1981 Jul;31(7):866–871. doi: 10.1212/wnl.31.7.866. [DOI] [PubMed] [Google Scholar]
  23. Trusiewicz D. Farnsworth 100-hue test in diagnosis of ethambutol-induced damage to optic nerve. Ophthalmologica. 1975;171(6):425–431. doi: 10.1159/000307566. [DOI] [PubMed] [Google Scholar]
  24. Zeese J. A. Pattern visual evoked responses in multiple sclerosis. Arch Neurol. 1977 May;34(5):314–316. doi: 10.1001/archneur.1977.00500170068015. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES