Abstract
Histocompatibility antigen (HLA A, B and DR) serotyping was performed on 65 patients with motor neuron disease in the northern region of England and compared to a large control population from the Newcastle upon Tyne area. Thirty two patients had amyotrophic lateral sclerosis, 17 had progressive bulbar palsy and 16 had progressive muscular atrophy. Ten patients had a more slowly progressive course. No significant HLA associations were observed in the motor neuron disease patients. Subdivision of the patients by the clinical course of their disease did not reveal any significant associations. Forty six motor neuron disease patients from the Newcastle upon Tyne area had a reduced frequency of HLA DR4 compared to the local control population. The relevance of histocompatibility antigens to the pathogenesis of motor neuron disease is discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Antel J. P., Arnason B. G., Fuller T. C., Lehrich J. R. Histocompatibility typing in amyotrophic lateral sclerosis. Arch Neurol. 1976 Jun;33(6):423–425. doi: 10.1001/archneur.1976.00500060029007. [DOI] [PubMed] [Google Scholar]
- Bartfeld H., Pollack M. S., Cunningham-Rundles S., Donnenfeld H. HLA frequencies in amyotrophic lateral sclerosis. Arch Neurol. 1982 May;39(5):270–271. doi: 10.1001/archneur.1982.00510170012003. [DOI] [PubMed] [Google Scholar]
- Behan P. O., Durward W. F., Dick H. Histocompatibility antigens associated with motor-neurone disease. Lancet. 1976 Oct 9;2(7989):803–803. doi: 10.1016/s0140-6736(76)90638-3. [DOI] [PubMed] [Google Scholar]
- Dewar P. J. The role of the laboratory in rheumatology. HLA antigens. Clin Rheum Dis. 1983 Apr;9(1):93–116. [PubMed] [Google Scholar]
- Gurney M. E., Belton A. C., Cashman N., Antel J. P. Inhibition of terminal axonal sprouting by serum from patients with amyotrophic lateral sclerosis. N Engl J Med. 1984 Oct 11;311(15):933–939. doi: 10.1056/NEJM198410113111501. [DOI] [PubMed] [Google Scholar]
- Jokelainen M., Tiilikainen A., Lapinleimu K. Polio antibodies and HLA antigens in amyotrophic lateral sclerosis. Tissue Antigens. 1977 Oct;10(4):259–266. doi: 10.1111/j.1399-0039.1977.tb00755.x. [DOI] [PubMed] [Google Scholar]
- Kott E., Livni E., Zamir R., Kuritzky A. Cell-mediated immunity to polio and HLA antigens in amyotrophic lateral sclerosis. Neurology. 1979 Jul;29(7):1040–1044. doi: 10.1212/wnl.29.7.1040. [DOI] [PubMed] [Google Scholar]
- Mittal K. K., Mickey M. R., Singal D. P., Terasaki P. I. Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation. 1968 Nov;6(8):913–927. doi: 10.1097/00007890-196811000-00006. [DOI] [PubMed] [Google Scholar]
- Pedersen L., Platz P., Jersild C., Thomsen M. HLA (SD and LD) in patients with amyotrophic lateral sclerosis (ALS). J Neurol Sci. 1977 Apr;31(3):313–318. doi: 10.1016/0022-510x(77)90210-6. [DOI] [PubMed] [Google Scholar]
- Seignalet J., Cadilhac J., Lapinski H. HLA et sclérose latérale amyotrophique. Sem Hop. 1979 Jun 18;55(23-26):1239–1240. [PubMed] [Google Scholar]