Abstract
IgG kappa paraproteinaemia was discovered in one patient with amyotrophic lateral sclerosis and one with chronic spinal muscular atrophy. Serum from these patients was injected into mouse muscles paralysed by botulinum toxin which is known to induce sprouting from motor nerve terminals. Daily injection of serum for 7 days failed to inhibit terminal sprouting. It is concluded that the paraproteins did not recognise a growth factor postulated as being implicated in the pathogenesis of motor neuron disease.
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- Brown M. C., Holland R. L., Ironton R. Nodal and terminal sprouting from motor nerves in fast and slow muscles of the mouse. J Physiol. 1980 Sep;306:493–510. doi: 10.1113/jphysiol.1980.sp013410. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown M. C., Ironton R. Motor neurone sprouting induced by prolonged tetrodotoxin block of nerve action potentials. Nature. 1977 Feb 3;265(5593):459–461. doi: 10.1038/265459a0. [DOI] [PubMed] [Google Scholar]
- Duchen L. W. Changes in motor innervation and cholinesterase localization induced by botulinum toxin in skeletal muscle of the mouse: differences between fast and slow muscles. J Neurol Neurosurg Psychiatry. 1970 Feb;33(1):40–54. doi: 10.1136/jnnp.33.1.40. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Duchen L. W., Strich S. J. The effects of botulinum toxin on the pattern of innervation of skeletal muscle in the mouse. Q J Exp Physiol Cogn Med Sci. 1968 Jan;53(1):84–89. doi: 10.1113/expphysiol.1968.sp001948. [DOI] [PubMed] [Google Scholar]
- Duchen L. W., Tonge D. A. The effects of implantation of an extra nerve on axonal sprouting usually induced by botulinum toxin in skeletal muscle of the mouse. J Anat. 1977 Sep;124(Pt 1):205–215. [PMC free article] [PubMed] [Google Scholar]
- Gurney M. E., Belton A. C., Cashman N., Antel J. P. Inhibition of terminal axonal sprouting by serum from patients with amyotrophic lateral sclerosis. N Engl J Med. 1984 Oct 11;311(15):933–939. doi: 10.1056/NEJM198410113111501. [DOI] [PubMed] [Google Scholar]
- Gurney M. E. Suppression of sprouting at the neuromuscular junction by immune sera. Nature. 1984 Feb 9;307(5951):546–548. doi: 10.1038/307546a0. [DOI] [PubMed] [Google Scholar]
- Holland R. L., Brown M. C. Postsynaptic transmission block can cause terminal sprouting of a motor nerve. Science. 1980 Feb 8;207(4431):649–651. doi: 10.1126/science.6243417. [DOI] [PubMed] [Google Scholar]
- Slack J. R., Hopkins W. G., Pockett S. Evidence for a motor nerve growth factor. Muscle Nerve. 1983 May;6(4):243–252. doi: 10.1002/mus.880060402. [DOI] [PubMed] [Google Scholar]