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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1986 Aug;49(8):867–873. doi: 10.1136/jnnp.49.8.867

Hypersexuality or altered sexual preference following brain injury.

B L Miller, J L Cummings, H McIntyre, G Ebers, M Grode
PMCID: PMC1028946  PMID: 3746322

Abstract

Eight patients are described in whom either hypersexuality (four cases) or change in sexual preference (four cases) occurred following brain injury. In this series disinhibition of sexual activity and hypersexuality followed medial basal-frontal or diencephalic injury. This contrasted with the patients demonstrating altered sexual preference whose injuries involved limbic system structures. In some patients altered sexual behaviour may be the presenting or dominant feature of brain injury.

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Selected References

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  1. BAUER H. G. Endocrine and metabolic conditions related to pathology in the hypothalamus: a review. J Nerv Ment Dis. 1959 Apr;128(4):323–338. [PubMed] [Google Scholar]
  2. Berlin F. S., Coyle G. S. Sexual deviation syndromes. Johns Hopkins Med J. 1981 Sep;149(3):119–125. [PubMed] [Google Scholar]
  3. Blumer D. Hypersexual episodes in temporal lobe epilepsy. Am J Psychiatry. 1970 Feb;126(8):1099–1106. doi: 10.1176/ajp.126.8.1099. [DOI] [PubMed] [Google Scholar]
  4. Brown E., Brown G. M., Kofman O., Quarrington B. Sexual function and affect in parkinsonian men treated with L-dopa. Am J Psychiatry. 1978 Dec;135(12):1552–1555. doi: 10.1176/ajp.135.12.1552. [DOI] [PubMed] [Google Scholar]
  5. Clark J. T., Smith E. R., Davidson J. M. Enhancement of sexual motivation in male rats by yohimbine. Science. 1984 Aug 24;225(4664):847–849. doi: 10.1126/science.6474156. [DOI] [PubMed] [Google Scholar]
  6. Comings D. E., Comings B. G. A case of familial exhibitionism in Tourette's syndrome successfully treated with haloperidol. Am J Psychiatry. 1982 Jul;139(7):913–915. doi: 10.1176/ajp.139.7.913. [DOI] [PubMed] [Google Scholar]
  7. Cummings J. L., Mendez M. F. Secondary mania with focal cerebrovascular lesions. Am J Psychiatry. 1984 Sep;141(9):1084–1087. doi: 10.1176/ajp.141.9.1084. [DOI] [PubMed] [Google Scholar]
  8. Everitt B. J. Monoamines and the control of sexual behaviour. Psychol Med. 1983 Nov;13(4):715–720. doi: 10.1017/s0033291700051412. [DOI] [PubMed] [Google Scholar]
  9. Gorski R. A., Gordon J. H., Shryne J. E., Southam A. M. Evidence for a morphological sex difference within the medial preoptic area of the rat brain. Brain Res. 1978 Jun 16;148(2):333–346. doi: 10.1016/0006-8993(78)90723-0. [DOI] [PubMed] [Google Scholar]
  10. Henn F. A., Herjanic M., Vanderpearl R. H. Forensic psychiatry: profiles of two types of sex offenders. Am J Psychiatry. 1976 Jun;133(6):694–696. doi: 10.1176/ajp.133.6.694. [DOI] [PubMed] [Google Scholar]
  11. Herzog A. G., Russell V., Vaitukaitis J. L., Geschwind N. Neuroendocrine dysfunction in temporal lobe epilepsy. Arch Neurol. 1982 Mar;39(3):133–135. doi: 10.1001/archneur.1982.00510150003001. [DOI] [PubMed] [Google Scholar]
  12. Lilly R., Cummings J. L., Benson D. F., Frankel M. The human Klüver-Bucy syndrome. Neurology. 1983 Sep;33(9):1141–1145. doi: 10.1212/wnl.33.9.1141. [DOI] [PubMed] [Google Scholar]
  13. Lisk R. D. Increased sexual behavior in the male rat following lesions in the mammillary region. J Exp Zool. 1966 Feb;161(1):129–136. doi: 10.1002/jez.1401610112. [DOI] [PubMed] [Google Scholar]
  14. MITCHELL W., FALCONER M. A., HILL D. Epilepsy with fetishism relieved by temporal lobectomy. Lancet. 1954 Sep 25;267(6839):626–630. doi: 10.1016/s0140-6736(54)90404-3. [DOI] [PubMed] [Google Scholar]
  15. MONEY J. Phantom orgasm in the dreams of paraplegic men and women. Arch Gen Psychiatry. 1960 Oct;3:373–382. doi: 10.1001/archpsyc.1960.01710040043007. [DOI] [PubMed] [Google Scholar]
  16. Nauta W. J. Neural associations of the frontal cortex. Acta Neurobiol Exp (Wars) 1972;32(2):125–140. [PubMed] [Google Scholar]
  17. POECK K., PILLERI G. RELEASE OF HYPERSEXUAL BEHAVIOUR DUE TO LESION IN THE LIMBIC SYSTEM. Acta Neurol Scand. 1965;41:233–244. doi: 10.1111/j.1600-0404.1965.tb04295.x. [DOI] [PubMed] [Google Scholar]
  18. Pardridge W. M., Gorski R. A., Lippe B. M., Green R. Androgens and sexual behavior. Ann Intern Med. 1982 Apr;96(4):488–501. doi: 10.7326/0003-4819-96-4-488. [DOI] [PubMed] [Google Scholar]
  19. Paulson G. W. Use of pyridoxine in chorea. Am J Psychiatry. 1971 Feb;127(8):1091–1092. doi: 10.1176/ajp.127.8.1091. [DOI] [PubMed] [Google Scholar]
  20. Regestein Q. R., Reich P. Pedophilia occurring after onset of cognitive impairment. J Nerv Ment Dis. 1978 Nov;166(11):794–798. doi: 10.1097/00005053-197811000-00007. [DOI] [PubMed] [Google Scholar]
  21. Rémillard G. M., Andermann F., Testa G. F., Gloor P., Aubé M., Martin J. B., Feindel W., Guberman A., Simpson C. Sexual ictal manifestations predominate in women with temporal lobe epilepsy: a finding suggesting sexual dimorphism in the human brain. Neurology. 1983 Mar;33(3):323–330. doi: 10.1212/wnl.33.3.323. [DOI] [PubMed] [Google Scholar]
  22. Shapiro S. K. Hypersexual behavior complicating levodopa (I-dopa) therapy. Minn Med. 1973 Jan;56(1):58–59. [PubMed] [Google Scholar]
  23. Shraberg D., Weisberg L. The Klüver-Bucy syndrome in man. J Nerv Ment Dis. 1978 Feb;166(2):130–134. doi: 10.1097/00005053-197802000-00008. [DOI] [PubMed] [Google Scholar]
  24. TERZIAN H., ORE G. D. Syndrome of Klüver and Bucy; reproduced in man by bilateral removal of the temporal lobes. Neurology. 1955 Jun;5(6):373–380. doi: 10.1212/wnl.5.6.373. [DOI] [PubMed] [Google Scholar]

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