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. 1986 Aug;49(8):937–944. doi: 10.1136/jnnp.49.8.937

Presynaptic inhibition of monosynaptic reflexes in the lower limbs of subjects with upper motoneuron disease.

J F Iles, R C Roberts
PMCID: PMC1028957  PMID: 2943875

Abstract

Presynaptic inhibition of muscle spindle Ia afferents by group I afferents from the same and other muscles has been studied in the lower limbs of subjects with upper motoneuron lesions. The experiments utilised conditioning of soleus test monosynaptic reflexes during controlled voluntary contraction. The protocol was designed to isolate presynaptic inhibition from postsynaptic components. The relation between estimate of inhibition and test reflex amplitude was examined. The subjects showed less inhibition than controls at all levels of voluntary torque investigated (less than or equal 15 Nm). Two thirds had weak inhibition which did not show the decrease during muscle contraction characteristic of controls. The degree of difference from the normal situation correlated with severity of the clinical sign (weakness of voluntary ankle flexion).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashby P., Verrier M., Lightfoot E. Segmental reflex pathways in spinal shock and spinal spasticity in man. J Neurol Neurosurg Psychiatry. 1974 Dec;37(12):1352–1360. doi: 10.1136/jnnp.37.12.1352. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ashby P., Verrier M. Neurophysiologic changes in hemiplegia. Possible explanation for the initial disparity between muscle tone and tendon reflexes. Neurology. 1976 Dec;26(12):1145–1151. doi: 10.1212/wnl.26.12.1145. [DOI] [PubMed] [Google Scholar]
  3. Ashby P., Verrier M. Neurophysiological changes following spinal cord lesions in man. Can J Neurol Sci. 1975 May;2(2):91–100. doi: 10.1017/s0317167100020060. [DOI] [PubMed] [Google Scholar]
  4. BASMAJIAN J. V., SZATMARI A. Effect of largactil (chlorpromazine) on human spasticity and electromyogram; preliminary report. AMA Arch Neurol Psychiatry. 1955 Feb;73(2):224–231. doi: 10.1001/archneurpsyc.1955.02330080102019. [DOI] [PubMed] [Google Scholar]
  5. Brink E., Jankowska E., Skoog B. Convergence onto interneurons subserving primary afferent depolarization of group I afferents. J Neurophysiol. 1984 Mar;51(3):432–449. doi: 10.1152/jn.1984.51.3.432. [DOI] [PubMed] [Google Scholar]
  6. Burke D., Ashby P. Are spinal "presynaptic" inhibitory mechanisms suppressed in spasticity? J Neurol Sci. 1972 Mar;15(3):321–326. doi: 10.1016/0022-510x(72)90073-1. [DOI] [PubMed] [Google Scholar]
  7. Devanandan M. S., Eccles R. M., Stenhouse D. Presynaptic inhibition evoked by muscle contraction. J Physiol. 1966 Jul;185(2):471–485. doi: 10.1113/jphysiol.1966.sp007997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Dimitrijević M. R., Nathan P. W. Studies of spasticity in man. I. Some features of spasticity. Brain. 1967 Mar;90(1):1–30. doi: 10.1093/brain/90.1.1. [DOI] [PubMed] [Google Scholar]
  9. Hongo T., Jankowska E., Lundberg A. The rubrospinal tract. 3. Effects on primary afferent terminals. Exp Brain Res. 1972;15(1):39–53. doi: 10.1007/BF00234957. [DOI] [PubMed] [Google Scholar]
  10. Lees A. J., Robertson M., Trimble M. R., Murray N. M. A clinical study of Gilles de la Tourette syndrome in the United Kingdom. J Neurol Neurosurg Psychiatry. 1984 Jan;47(1):1–8. doi: 10.1136/jnnp.47.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mizrahi E. M., Angel R. W. Impairment of voluntary movement by spasticity. Ann Neurol. 1979 Jun;5(6):594–595. doi: 10.1002/ana.410050620. [DOI] [PubMed] [Google Scholar]
  12. Nathan P. W., Smith M. C. The rubrospinal and central tegmental tracts in man. Brain. 1982 Jun;105(Pt 2):223–269. doi: 10.1093/brain/105.2.223. [DOI] [PubMed] [Google Scholar]
  13. Read D. J., Matthews W. B., Higson R. H. The effect of spinal cord stimulation on function in patients with multiple sclerosis. Brain. 1980 Dec;103(4):803–833. doi: 10.1093/brain/103.4.803. [DOI] [PubMed] [Google Scholar]
  14. Rudomín P., Jiménez I., Solodkin M., Dueñas S. Sites of action of segmental and descending control of transmission on pathways mediating PAD of Ia- and Ib-afferent fibers in cat spinal cord. J Neurophysiol. 1983 Oct;50(4):743–769. doi: 10.1152/jn.1983.50.4.743. [DOI] [PubMed] [Google Scholar]
  15. Somerville J., Ashby P. Hemiplegic spasticity: neurophysiologic studies. Arch Phys Med Rehabil. 1978 Dec;59(12):592–596. [PubMed] [Google Scholar]

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