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. 1993 Jan;68(1):120–122. doi: 10.1136/adc.68.1.120

Cystic fibrosis in Asians.

I M Bowler 1, E J Estlin 1, J M Littlewood 1
PMCID: PMC1029197  PMID: 8434995

Abstract

The clinical course of cystic fibrosis in nine Pakistani Asians was compared with 18 non-Asian age and sex matched controls. The Asian patients grew Pseudomonas aeruginosa at an earlier age (4.0 v 7.5 years), tended to have lower respiratory function test results (forced vital capacity 58.5 v 76.8% predicted; forced expiratory volume in one second 79.8 v 100.3% predicted), and had significantly greater concentrations of immunoglobulin IgG (13.4 v 10.1 g/l). They had a lower weight for age (78.4 v 95.7%) and weight for height (90 v 98.5%) despite similar intakes of dietary energy. Four of the nine Asians carried the delta F508 mutation compared with 17 of 18 controls. All the Asian patients were born in the UK; seven of their mothers were born in Pakistan and had moderate or severe difficulties with the English language. It is concluded that Asian patients may have a more severe clinical course than matched controls and that genetic and environmental factors may be contributory.

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Selected References

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  1. Black J. Growth performance of affluent Indian children under 5 years of age. Arch Dis Child. 1992 May;67(5):666–666. doi: 10.1136/adc.67.5.666. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Britton J. R. Effects of social class, sex, and region of residence on age at death from cystic fibrosis. BMJ. 1989 Feb 25;298(6672):483–487. doi: 10.1136/bmj.298.6672.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chrispin A. R., Norman A. P. The systematic evaluation of the chest radiograph in cystic fibrosis. Pediatr Radiol. 1974;2(2):101–105. doi: 10.1007/BF01314939. [DOI] [PubMed] [Google Scholar]
  4. Evans R. T., Little A. J., Steel A. E., Littlewood J. M. Satisfactory screening for cystic fibrosis with the BM meconium procedure. J Clin Pathol. 1981 Aug;34(8):911–913. doi: 10.1136/jcp.34.8.911. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fallon J. S., Brocklebank J. T., Simmonds E. J., Littlewood J. M. Cystic fibrosis and renal tubular acidosis. Arch Dis Child. 1989 Jul;64(7):1054–1055. doi: 10.1136/adc.64.7.1054. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GIBSON L. E., COOKE R. E. A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis. Pediatrics. 1959 Mar;23(3):545–549. [PubMed] [Google Scholar]
  7. Gaskin K., Gurwitz D., Durie P., Corey M., Levison H., Forstner G. Improved respiratory prognosis in patients with cystic fibrosis with normal fat absorption. J Pediatr. 1982 Jun;100(6):857–862. doi: 10.1016/s0022-3476(82)80501-5. [DOI] [PubMed] [Google Scholar]
  8. Gilbert J., Kelleher J., Walters M. P., Littlewood J. M. Markers for faecal fat estimation in monitoring steatorrhoea in cystic fibrosis. Gut. 1988 Sep;29(9):1286–1288. doi: 10.1136/gut.29.9.1286. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gillies D. R., Lealman G. T., Lumb K. M., Congdon P. Analysis of ethnic influence on stillbirths and infant mortality in Bradford 1975-81. J Epidemiol Community Health. 1984 Sep;38(3):214–217. doi: 10.1136/jech.38.3.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Goodchild M. C., Insley J., Rushton D. I., Gaze H. Cystic fibrosis in 3 Pakistani children. Arch Dis Child. 1974 Sep;49(9):739–741. doi: 10.1136/adc.49.9.739. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kerem B., Rommens J. M., Buchanan J. A., Markiewicz D., Cox T. K., Chakravarti A., Buchwald M., Tsui L. C. Identification of the cystic fibrosis gene: genetic analysis. Science. 1989 Sep 8;245(4922):1073–1080. doi: 10.1126/science.2570460. [DOI] [PubMed] [Google Scholar]
  12. Kraemer R., Rüdeberg A., Hadorn B., Rossi E. Relative underweight in cystic fibrosis and its prognostic value. Acta Paediatr Scand. 1978 Jan;67(1):33–37. doi: 10.1111/j.1651-2227.1978.tb16273.x. [DOI] [PubMed] [Google Scholar]
  13. Kulczycki L. L., Schauf V. Cystic fibrosis in blacks in Washington, DC: incidence and characteristics. Am J Dis Child. 1974 Jan;127(1):64–67. doi: 10.1001/archpedi.1974.02110200066009. [DOI] [PubMed] [Google Scholar]
  14. McColley S. A., Rosenstein B. J., Cutting G. R. Differences in expression of cystic fibrosis in blacks and whites. Am J Dis Child. 1991 Jan;145(1):94–97. doi: 10.1001/archpedi.1991.02160010100025. [DOI] [PubMed] [Google Scholar]
  15. Riordan J. R., Rommens J. M., Kerem B., Alon N., Rozmahel R., Grzelczak Z., Zielenski J., Lok S., Plavsic N., Chou J. L. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science. 1989 Sep 8;245(4922):1066–1073. doi: 10.1126/science.2475911. [DOI] [PubMed] [Google Scholar]
  16. Rommens J. M., Iannuzzi M. C., Kerem B., Drumm M. L., Melmer G., Dean M., Rozmahel R., Cole J. L., Kennedy D., Hidaka N. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science. 1989 Sep 8;245(4922):1059–1065. doi: 10.1126/science.2772657. [DOI] [PubMed] [Google Scholar]
  17. SHWACHMAN H., KULCZYCKI L. L. Long-term study of one hundred five patients with cystic fibrosis; studies made over a five- to fourteen-year period. AMA J Dis Child. 1958 Jul;96(1):6–15. doi: 10.1001/archpedi.1958.02060060008002. [DOI] [PubMed] [Google Scholar]
  18. Schwarz M. J., Super M., Wallis C., Beighton P., Newton C., Heptinstall L. E., Summers C., Markham A., Hambleton G., Webb K. W. Delta F508 testing of the DNA bank of the Royal Manchester Children's Hospital. Hum Genet. 1990 Sep;85(4):428–430. doi: 10.1007/BF02428298. [DOI] [PubMed] [Google Scholar]
  19. Stern R. C., Doershuk C. F., Boat T. F., Tucker A. S., Primiano F. P., Jr, Matthews L. W. Course of cystic fibrosis in black patients. J Pediatr. 1976 Sep;89(3):412–417. doi: 10.1016/s0022-3476(76)80538-0. [DOI] [PubMed] [Google Scholar]
  20. Tanner J. M., Whitehouse R. H. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child. 1976 Mar;51(3):170–179. doi: 10.1136/adc.51.3.170. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Vaisman N., Pencharz P. B., Corey M., Canny G. J., Hahn E. Energy expenditure of patients with cystic fibrosis. J Pediatr. 1987 Oct;111(4):496–500. doi: 10.1016/s0022-3476(87)80107-5. [DOI] [PubMed] [Google Scholar]
  22. Wheeler W. B., Williams M., Matthews W. J., Jr, Colten H. R. Progression of cystic fibrosis lung disease as a function of serum immunoglobulin G levels: a 5-year longitudinal study. J Pediatr. 1984 May;104(5):695–699. doi: 10.1016/s0022-3476(84)80946-4. [DOI] [PubMed] [Google Scholar]
  23. Wilmott R. W., Tyson S. L., Matthew D. J. Cystic fibrosis survival rates. The influences of allergy and Pseudomonas aeruginosa. Am J Dis Child. 1985 Jul;139(7):669–671. doi: 10.1001/archpedi.1985.02140090031019. [DOI] [PubMed] [Google Scholar]

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